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Gene: DEPDC5 |
Gene summary for DEPDC5 |
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Gene information | Species | Human | Gene symbol | DEPDC5 | Gene ID | 9681 |
Gene name | DEP domain containing 5, GATOR1 subcomplex subunit | |
Gene Alias | DEP.5 | |
Cytomap | 22q12.2-q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | O75140 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9681 | DEPDC5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.02e-11 | 2.37e-01 | 0.0155 |
9681 | DEPDC5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.43e-18 | 4.98e-01 | -0.1808 |
9681 | DEPDC5 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 3.89e-01 | 0.0216 |
9681 | DEPDC5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.53e-23 | 6.33e-01 | -0.0811 |
9681 | DEPDC5 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.86e-16 | 4.36e-01 | -0.1088 |
9681 | DEPDC5 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.69e-50 | 8.41e-01 | -0.1954 |
9681 | DEPDC5 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-12 | 7.18e-01 | -0.2602 |
9681 | DEPDC5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.08e-06 | 4.24e-01 | -0.2196 |
9681 | DEPDC5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.93e-12 | 4.18e-01 | -0.1207 |
9681 | DEPDC5 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.68e-22 | 6.66e-01 | -0.1526 |
9681 | DEPDC5 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.45e-42 | 7.89e-01 | -0.1464 |
9681 | DEPDC5 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.14e-33 | 5.83e-01 | -0.1001 |
9681 | DEPDC5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.25e-24 | 6.20e-01 | -0.059 |
9681 | DEPDC5 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.52e-10 | 5.85e-01 | -0.1706 |
9681 | DEPDC5 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.00e-07 | 3.82e-01 | -0.2061 |
9681 | DEPDC5 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.36e-01 | -0.1462 |
9681 | DEPDC5 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.57e-20 | 6.83e-01 | -0.0842 |
9681 | DEPDC5 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.20e-07 | 4.38e-01 | -0.00410000000000005 |
9681 | DEPDC5 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.36e-06 | 3.05e-01 | -0.0179 |
9681 | DEPDC5 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.97e-15 | 3.40e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0042594 | Colorectum | AD | response to starvation | 63/3918 | 197/18723 | 1.77e-04 | 2.38e-03 | 63 |
GO:0071496 | Colorectum | AD | cellular response to external stimulus | 94/3918 | 320/18723 | 1.98e-04 | 2.64e-03 | 94 |
GO:0009267 | Colorectum | AD | cellular response to starvation | 51/3918 | 156/18723 | 3.90e-04 | 4.44e-03 | 51 |
GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
GO:0031669 | Colorectum | AD | cellular response to nutrient levels | 63/3918 | 215/18723 | 2.19e-03 | 1.73e-02 | 63 |
GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
GO:00105061 | Colorectum | SER | regulation of autophagy | 74/2897 | 317/18723 | 1.39e-04 | 2.77e-03 | 74 |
GO:00425941 | Colorectum | SER | response to starvation | 47/2897 | 197/18723 | 1.31e-03 | 1.45e-02 | 47 |
GO:00714961 | Colorectum | SER | cellular response to external stimulus | 70/2897 | 320/18723 | 1.40e-03 | 1.53e-02 | 70 |
GO:00092671 | Colorectum | SER | cellular response to starvation | 38/2897 | 156/18723 | 2.45e-03 | 2.32e-02 | 38 |
GO:00316681 | Colorectum | SER | cellular response to extracellular stimulus | 54/2897 | 246/18723 | 4.26e-03 | 3.45e-02 | 54 |
GO:00316691 | Colorectum | SER | cellular response to nutrient levels | 48/2897 | 215/18723 | 4.82e-03 | 3.78e-02 | 48 |
GO:00105062 | Colorectum | MSS | regulation of autophagy | 95/3467 | 317/18723 | 4.36e-07 | 1.71e-05 | 95 |
GO:00316672 | Colorectum | MSS | response to nutrient levels | 125/3467 | 474/18723 | 1.24e-05 | 2.88e-04 | 125 |
GO:00425942 | Colorectum | MSS | response to starvation | 56/3467 | 197/18723 | 4.25e-04 | 5.21e-03 | 56 |
GO:00714962 | Colorectum | MSS | cellular response to external stimulus | 82/3467 | 320/18723 | 9.30e-04 | 9.44e-03 | 82 |
GO:00092672 | Colorectum | MSS | cellular response to starvation | 44/3467 | 156/18723 | 1.96e-03 | 1.69e-02 | 44 |
GO:00316692 | Colorectum | MSS | cellular response to nutrient levels | 56/3467 | 215/18723 | 3.80e-03 | 2.79e-02 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04150 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa041501 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DEPDC5 | SNV | Missense_Mutation | novel | c.2404N>C | p.Phe802Leu | p.F802L | O75140 | protein_coding | tolerated(0.98) | benign(0.078) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DEPDC5 | SNV | Missense_Mutation | c.1186G>A | p.Asp396Asn | p.D396N | O75140 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
DEPDC5 | insertion | Nonsense_Mutation | novel | c.1930_1931insTGGGAT | p.Gln644delinsLeuGlyTer | p.Q644delinsLG* | O75140 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DEPDC5 | SNV | Missense_Mutation | rs564667614 | c.2591C>T | p.Thr864Met | p.T864M | O75140 | protein_coding | deleterious(0.01) | possibly_damaging(0.742) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DEPDC5 | SNV | Missense_Mutation | novel | c.85N>T | p.Val29Leu | p.V29L | O75140 | protein_coding | tolerated(0.46) | possibly_damaging(0.637) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DEPDC5 | SNV | Missense_Mutation | novel | c.852N>T | p.Leu284Phe | p.L284F | O75140 | protein_coding | deleterious(0.01) | probably_damaging(0.938) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DEPDC5 | SNV | Missense_Mutation | novel | c.2598N>T | p.Lys866Asn | p.K866N | O75140 | protein_coding | tolerated(0.27) | probably_damaging(0.972) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DEPDC5 | SNV | Missense_Mutation | rs748634683 | c.2035N>A | p.Gly679Ser | p.G679S | O75140 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
DEPDC5 | SNV | Missense_Mutation | rs756611357 | c.2528N>A | p.Arg843Gln | p.R843Q | O75140 | protein_coding | tolerated(0.19) | possibly_damaging(0.744) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
DEPDC5 | SNV | Missense_Mutation | novel | c.542N>G | p.Met181Arg | p.M181R | O75140 | protein_coding | deleterious(0) | possibly_damaging(0.762) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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