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Gene: DENND4B |
Gene summary for DENND4B |
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Gene information | Species | Human | Gene symbol | DENND4B | Gene ID | 9909 |
Gene name | DENN domain containing 4B | |
Gene Alias | KIAA0476 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | O75064 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9909 | DENND4B | HCC1_Meng | Human | Liver | HCC | 1.04e-16 | 2.19e-02 | 0.0246 |
9909 | DENND4B | HCC1 | Human | Liver | HCC | 4.22e-04 | 2.41e+00 | 0.5336 |
9909 | DENND4B | HCC2 | Human | Liver | HCC | 8.13e-12 | 2.30e+00 | 0.5341 |
9909 | DENND4B | S016 | Human | Liver | HCC | 2.85e-06 | 2.42e-01 | 0.2243 |
9909 | DENND4B | S028 | Human | Liver | HCC | 1.68e-04 | 2.61e-01 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:004657811 | Liver | HCC | regulation of Ras protein signal transduction | 100/7958 | 189/18723 | 2.42e-03 | 1.18e-02 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DENND4B | SNV | Missense_Mutation | rs763865336 | c.3398G>A | p.Arg1133His | p.R1133H | O75064 | protein_coding | tolerated(0.1) | benign(0) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DENND4B | SNV | Missense_Mutation | novel | c.2987C>A | p.Pro996His | p.P996H | O75064 | protein_coding | deleterious(0.02) | benign(0.21) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DENND4B | SNV | Missense_Mutation | c.788T>G | p.Leu263Arg | p.L263R | O75064 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DENND4B | SNV | Missense_Mutation | rs764671818 | c.2519N>A | p.Arg840His | p.R840H | O75064 | protein_coding | deleterious(0.03) | possibly_damaging(0.613) | TCGA-CM-6169-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Ancillary | leucovorin | SD |
DENND4B | SNV | Missense_Mutation | c.4135G>A | p.Val1379Ile | p.V1379I | O75064 | protein_coding | tolerated(0.38) | benign(0.011) | TCGA-D5-5539-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fu | PD | |
DENND4B | SNV | Missense_Mutation | c.2222N>A | p.Arg741His | p.R741H | O75064 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DENND4B | SNV | Missense_Mutation | rs751314491 | c.763N>A | p.Val255Met | p.V255M | O75064 | protein_coding | deleterious(0.02) | benign(0.068) | TCGA-DM-A28H-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
DENND4B | SNV | Missense_Mutation | c.412N>A | p.Pro138Thr | p.P138T | O75064 | protein_coding | tolerated(0.59) | possibly_damaging(0.888) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DENND4B | SNV | Missense_Mutation | rs202061696 | c.3308N>A | p.Arg1103His | p.R1103H | O75064 | protein_coding | deleterious(0) | benign(0.003) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
DENND4B | SNV | Missense_Mutation | rs368445195 | c.2929N>A | p.Gly977Ser | p.G977S | O75064 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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