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Gene: DDX11 |
Gene summary for DDX11 |
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Gene information | Species | Human | Gene symbol | DDX11 | Gene ID | 1663 |
Gene name | DEAD/H-box helicase 11 | |
Gene Alias | CHL1 | |
Cytomap | 12p11.21 | |
Gene Type | protein-coding | GO ID | GO:0000819 | UniProtAcc | Q96FC9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1663 | DDX11 | LZE7T | Human | Esophagus | ESCC | 5.63e-09 | 2.61e-01 | 0.0667 |
1663 | DDX11 | LZE21D1 | Human | Esophagus | HGIN | 2.16e-02 | 1.88e-01 | 0.0632 |
1663 | DDX11 | LZE24T | Human | Esophagus | ESCC | 7.03e-03 | 9.56e-02 | 0.0596 |
1663 | DDX11 | LZE21T | Human | Esophagus | ESCC | 1.22e-02 | 2.14e-01 | 0.0655 |
1663 | DDX11 | P1T-E | Human | Esophagus | ESCC | 2.46e-04 | 1.83e-01 | 0.0875 |
1663 | DDX11 | P2T-E | Human | Esophagus | ESCC | 7.28e-12 | 3.55e-01 | 0.1177 |
1663 | DDX11 | P4T-E | Human | Esophagus | ESCC | 8.55e-06 | 1.37e-01 | 0.1323 |
1663 | DDX11 | P5T-E | Human | Esophagus | ESCC | 3.07e-11 | 2.12e-01 | 0.1327 |
1663 | DDX11 | P8T-E | Human | Esophagus | ESCC | 1.25e-13 | 2.54e-01 | 0.0889 |
1663 | DDX11 | P9T-E | Human | Esophagus | ESCC | 9.68e-03 | 5.43e-02 | 0.1131 |
1663 | DDX11 | P10T-E | Human | Esophagus | ESCC | 1.00e-14 | 4.15e-01 | 0.116 |
1663 | DDX11 | P12T-E | Human | Esophagus | ESCC | 6.79e-09 | 2.18e-01 | 0.1122 |
1663 | DDX11 | P16T-E | Human | Esophagus | ESCC | 7.18e-17 | 4.37e-01 | 0.1153 |
1663 | DDX11 | P20T-E | Human | Esophagus | ESCC | 3.25e-10 | 2.51e-01 | 0.1124 |
1663 | DDX11 | P21T-E | Human | Esophagus | ESCC | 2.33e-02 | 6.10e-02 | 0.1617 |
1663 | DDX11 | P22T-E | Human | Esophagus | ESCC | 5.52e-12 | 2.66e-01 | 0.1236 |
1663 | DDX11 | P23T-E | Human | Esophagus | ESCC | 4.70e-05 | 1.01e-01 | 0.108 |
1663 | DDX11 | P24T-E | Human | Esophagus | ESCC | 1.73e-05 | 1.36e-01 | 0.1287 |
1663 | DDX11 | P26T-E | Human | Esophagus | ESCC | 1.41e-04 | 4.88e-02 | 0.1276 |
1663 | DDX11 | P27T-E | Human | Esophagus | ESCC | 3.11e-09 | 2.29e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200125218 | Esophagus | HGIN | positive regulation of chromosome organization | 30/2587 | 82/18723 | 2.00e-07 | 9.68e-06 | 30 |
GO:00330449 | Esophagus | HGIN | regulation of chromosome organization | 51/2587 | 187/18723 | 8.91e-07 | 3.61e-05 | 51 |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:005105214 | Esophagus | HGIN | regulation of DNA metabolic process | 79/2587 | 359/18723 | 1.38e-05 | 3.85e-04 | 79 |
GO:005109825 | Esophagus | HGIN | regulation of binding | 78/2587 | 363/18723 | 3.73e-05 | 9.30e-04 | 78 |
GO:200102019 | Esophagus | HGIN | regulation of response to DNA damage stimulus | 52/2587 | 219/18723 | 5.00e-05 | 1.19e-03 | 52 |
GO:005109925 | Esophagus | HGIN | positive regulation of binding | 42/2587 | 173/18723 | 1.51e-04 | 2.97e-03 | 42 |
GO:005105416 | Esophagus | HGIN | positive regulation of DNA metabolic process | 47/2587 | 201/18723 | 1.65e-04 | 3.21e-03 | 47 |
GO:00069975 | Esophagus | HGIN | nucleus organization | 34/2587 | 133/18723 | 2.20e-04 | 4.00e-03 | 34 |
GO:00070593 | Esophagus | HGIN | chromosome segregation | 71/2587 | 346/18723 | 3.47e-04 | 5.62e-03 | 71 |
GO:00323926 | Esophagus | HGIN | DNA geometric change | 25/2587 | 90/18723 | 3.77e-04 | 5.85e-03 | 25 |
GO:00325084 | Esophagus | HGIN | DNA duplex unwinding | 22/2587 | 84/18723 | 1.91e-03 | 2.03e-02 | 22 |
GO:190165318 | Esophagus | HGIN | cellular response to peptide | 68/2587 | 359/18723 | 3.88e-03 | 3.54e-02 | 68 |
GO:003209110 | Esophagus | HGIN | negative regulation of protein binding | 23/2587 | 94/18723 | 3.92e-03 | 3.54e-02 | 23 |
GO:005110020 | Esophagus | HGIN | negative regulation of binding | 35/2587 | 162/18723 | 4.32e-03 | 3.84e-02 | 35 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041109 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa0411016 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX11 | SNV | Missense_Mutation | novel | c.218A>G | p.Glu73Gly | p.E73G | Q96FC9 | protein_coding | tolerated(0.11) | possibly_damaging(0.495) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
DDX11 | SNV | Missense_Mutation | novel | c.1958T>A | p.Ile653Asn | p.I653N | Q96FC9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
DDX11 | SNV | Missense_Mutation | rs776904196 | c.2477N>T | p.Pro826Leu | p.P826L | Q96FC9 | protein_coding | deleterious(0.02) | benign(0.198) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
DDX11 | SNV | Missense_Mutation | novel | c.2807N>A | p.Pro936His | p.P936H | Q96FC9 | protein_coding | deleterious_low_confidence(0) | benign(0.094) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
DDX11 | SNV | Missense_Mutation | novel | c.1199N>G | p.Asp400Gly | p.D400G | Q96FC9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
DDX11 | SNV | Missense_Mutation | novel | c.1694N>G | p.His565Arg | p.H565R | Q96FC9 | protein_coding | tolerated(0.1) | benign(0.255) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
DDX11 | SNV | Missense_Mutation | rs775060008 | c.766N>T | p.Arg256Trp | p.R256W | Q96FC9 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX11 | SNV | Missense_Mutation | rs578127444 | c.2140C>T | p.Arg714Cys | p.R714C | Q96FC9 | protein_coding | deleterious(0.01) | possibly_damaging(0.908) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX11 | SNV | Missense_Mutation | rs17857386 | c.1724N>T | p.Thr575Met | p.T575M | Q96FC9 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX11 | SNV | Missense_Mutation | novel | c.1308N>T | p.Lys436Asn | p.K436N | Q96FC9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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