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Gene: DCLRE1C |
Gene summary for DCLRE1C |
Gene summary. |
Gene information | Species | Human | Gene symbol | DCLRE1C | Gene ID | 64421 |
Gene name | DNA cross-link repair 1C | |
Gene Alias | A-SCID | |
Cytomap | 10p13 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | Q96SD1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64421 | DCLRE1C | LZE22T | Human | Esophagus | ESCC | 5.58e-03 | 2.23e-01 | 0.068 |
64421 | DCLRE1C | LZE24T | Human | Esophagus | ESCC | 7.12e-11 | 4.51e-01 | 0.0596 |
64421 | DCLRE1C | LZE6T | Human | Esophagus | ESCC | 4.33e-02 | 1.28e-01 | 0.0845 |
64421 | DCLRE1C | P1T-E | Human | Esophagus | ESCC | 4.28e-06 | 6.42e-01 | 0.0875 |
64421 | DCLRE1C | P2T-E | Human | Esophagus | ESCC | 2.11e-11 | 2.19e-01 | 0.1177 |
64421 | DCLRE1C | P4T-E | Human | Esophagus | ESCC | 5.34e-07 | 1.48e-01 | 0.1323 |
64421 | DCLRE1C | P5T-E | Human | Esophagus | ESCC | 6.48e-04 | 9.53e-02 | 0.1327 |
64421 | DCLRE1C | P8T-E | Human | Esophagus | ESCC | 2.99e-09 | 1.60e-01 | 0.0889 |
64421 | DCLRE1C | P9T-E | Human | Esophagus | ESCC | 1.70e-02 | 5.19e-02 | 0.1131 |
64421 | DCLRE1C | P10T-E | Human | Esophagus | ESCC | 1.54e-11 | 1.68e-01 | 0.116 |
64421 | DCLRE1C | P12T-E | Human | Esophagus | ESCC | 2.53e-14 | 1.87e-01 | 0.1122 |
64421 | DCLRE1C | P15T-E | Human | Esophagus | ESCC | 1.31e-07 | 1.18e-01 | 0.1149 |
64421 | DCLRE1C | P16T-E | Human | Esophagus | ESCC | 6.04e-09 | 1.59e-01 | 0.1153 |
64421 | DCLRE1C | P20T-E | Human | Esophagus | ESCC | 6.06e-15 | 1.98e-01 | 0.1124 |
64421 | DCLRE1C | P21T-E | Human | Esophagus | ESCC | 4.68e-13 | 3.09e-01 | 0.1617 |
64421 | DCLRE1C | P23T-E | Human | Esophagus | ESCC | 1.56e-06 | 3.02e-01 | 0.108 |
64421 | DCLRE1C | P24T-E | Human | Esophagus | ESCC | 5.65e-10 | 1.92e-01 | 0.1287 |
64421 | DCLRE1C | P26T-E | Human | Esophagus | ESCC | 1.12e-06 | 1.66e-01 | 0.1276 |
64421 | DCLRE1C | P27T-E | Human | Esophagus | ESCC | 7.83e-12 | 2.45e-01 | 0.1055 |
64421 | DCLRE1C | P28T-E | Human | Esophagus | ESCC | 7.63e-04 | 5.58e-02 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001021217 | Esophagus | ESCC | response to ionizing radiation | 110/8552 | 148/18723 | 1.11e-12 | 4.78e-11 | 110 |
GO:000072319 | Esophagus | ESCC | telomere maintenance | 99/8552 | 131/18723 | 2.68e-12 | 1.08e-10 | 99 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:003220014 | Esophagus | ESCC | telomere organization | 99/8552 | 159/18723 | 1.77e-05 | 1.57e-04 | 99 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00162332 | Esophagus | ESCC | telomere capping | 28/8552 | 39/18723 | 8.57e-04 | 4.40e-03 | 28 |
GO:00025622 | Esophagus | ESCC | somatic diversification of immune receptors via germline recombination within a single locus | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
GO:0006303 | Esophagus | ESCC | double-strand break repair via nonhomologous end joining | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
GO:00164442 | Esophagus | ESCC | somatic cell DNA recombination | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
GO:00022003 | Esophagus | ESCC | somatic diversification of immune receptors | 49/8552 | 77/18723 | 1.12e-03 | 5.60e-03 | 49 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:00300984 | Esophagus | ESCC | lymphocyte differentiation | 192/8552 | 374/18723 | 1.52e-02 | 4.93e-02 | 192 |
GO:000072311 | Liver | HCC | telomere maintenance | 85/7958 | 131/18723 | 1.86e-07 | 3.40e-06 | 85 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:001021221 | Liver | HCC | response to ionizing radiation | 89/7958 | 148/18723 | 1.10e-05 | 1.26e-04 | 89 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
GO:00322001 | Liver | HCC | telomere organization | 86/7958 | 159/18723 | 2.06e-03 | 1.04e-02 | 86 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCLRE1C | SNV | Missense_Mutation | rs541855040 | c.1057G>A | p.Glu353Lys | p.E353K | Q96SD1 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DCLRE1C | SNV | Missense_Mutation | novel | c.495T>G | p.Asp165Glu | p.D165E | Q96SD1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DCLRE1C | SNV | Missense_Mutation | c.1484N>T | p.Arg495Ile | p.R495I | Q96SD1 | protein_coding | tolerated_low_confidence(0.18) | benign(0.063) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
DCLRE1C | SNV | Missense_Mutation | novel | c.515N>T | p.Arg172Ile | p.R172I | Q96SD1 | protein_coding | deleterious(0) | benign(0.436) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
DCLRE1C | SNV | Missense_Mutation | novel | c.1779N>T | p.Gln593His | p.Q593H | Q96SD1 | protein_coding | deleterious_low_confidence(0) | benign(0.015) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
DCLRE1C | SNV | Missense_Mutation | c.1667A>G | p.Asp556Gly | p.D556G | Q96SD1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.7) | TCGA-EY-A212-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
DCLRE1C | SNV | Missense_Mutation | rs762842349 | c.770N>A | p.Arg257Gln | p.R257Q | Q96SD1 | protein_coding | deleterious(0.01) | possibly_damaging(0.75) | TCGA-FI-A2EU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatinum | CR |
DCLRE1C | deletion | Frame_Shift_Del | c.2053delN | p.Arg685GlufsTer6 | p.R685Efs*6 | Q96SD1 | protein_coding | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
DCLRE1C | deletion | Frame_Shift_Del | novel | c.1375_1393delNNNNNNNNNNNNNNNNNNN | p.Glu460GlnfsTer78 | p.E460Qfs*78 | Q96SD1 | protein_coding | TCGA-EO-A3AS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DCLRE1C | SNV | Missense_Mutation | c.1355G>T | p.Cys452Phe | p.C452F | Q96SD1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-DD-A4NG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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