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Gene: CRX |
Gene summary for CRX |
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Gene information | Species | Human | Gene symbol | CRX | Gene ID | 1406 |
Gene name | cone-rod homeobox | |
Gene Alias | CORD2 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O43186 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1406 | CRX | HCC1 | Human | Liver | HCC | 1.84e-06 | 1.17e+00 | 0.5336 |
1406 | CRX | HCC2 | Human | Liver | HCC | 9.06e-18 | 1.29e+00 | 0.5341 |
1406 | CRX | HCC5 | Human | Liver | HCC | 4.86e-10 | 8.29e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRX | SNV | Missense_Mutation | novel | c.52N>A | p.Leu18Ile | p.L18I | O43186 | protein_coding | deleterious(0.01) | benign(0.147) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
CRX | SNV | Missense_Mutation | rs146869548 | c.649N>A | p.Gly217Ser | p.G217S | O43186 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
CRX | SNV | Missense_Mutation | novel | c.550N>A | p.Pro184Thr | p.P184T | O43186 | protein_coding | tolerated(0.47) | benign(0.096) | TCGA-97-7941-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRX | SNV | Missense_Mutation | c.586N>T | p.Ala196Ser | p.A196S | O43186 | protein_coding | tolerated(0.7) | benign(0.071) | TCGA-J2-8194-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
CRX | SNV | Missense_Mutation | c.101G>T | p.Ser34Ile | p.S34I | O43186 | protein_coding | deleterious(0.01) | benign(0.117) | TCGA-MP-A4TJ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CRX | SNV | Missense_Mutation | rs193920917 | c.107C>A | p.Pro36His | p.P36H | O43186 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRX | SNV | Missense_Mutation | novel | c.228N>G | p.Ile76Met | p.I76M | O43186 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-22-1000-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CRX | SNV | Missense_Mutation | rs863224863 | c.124N>A | p.Glu42Lys | p.E42K | O43186 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-34-2600-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRX | SNV | Missense_Mutation | rs751282380 | c.617C>T | p.Ser206Phe | p.S206F | O43186 | protein_coding | tolerated(0.33) | benign(0.084) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRX | SNV | Missense_Mutation | rs142111462 | c.565G>A | p.Ala189Thr | p.A189T | O43186 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-60-2712-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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