![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CPNE3 |
Gene summary for CPNE3 |
![]() |
Gene information | Species | Human | Gene symbol | CPNE3 | Gene ID | 8895 |
Gene name | copine 3 | |
Gene Alias | CPN3 | |
Cytomap | 8q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024R994 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8895 | CPNE3 | GSM4909281 | Human | Breast | IDC | 5.16e-08 | 3.55e-01 | 0.21 |
8895 | CPNE3 | GSM4909286 | Human | Breast | IDC | 1.22e-02 | 6.68e-02 | 0.1081 |
8895 | CPNE3 | GSM4909290 | Human | Breast | IDC | 6.01e-21 | 6.19e-01 | 0.2096 |
8895 | CPNE3 | GSM4909291 | Human | Breast | IDC | 8.25e-19 | 6.57e-01 | 0.1753 |
8895 | CPNE3 | GSM4909293 | Human | Breast | IDC | 1.19e-06 | 2.54e-01 | 0.1581 |
8895 | CPNE3 | GSM4909294 | Human | Breast | IDC | 3.82e-11 | 4.28e-01 | 0.2022 |
8895 | CPNE3 | GSM4909296 | Human | Breast | IDC | 7.92e-03 | -3.54e-02 | 0.1524 |
8895 | CPNE3 | GSM4909297 | Human | Breast | IDC | 1.78e-03 | -3.01e-02 | 0.1517 |
8895 | CPNE3 | GSM4909298 | Human | Breast | IDC | 1.62e-05 | 2.89e-01 | 0.1551 |
8895 | CPNE3 | GSM4909304 | Human | Breast | IDC | 1.32e-04 | 3.06e-01 | 0.1636 |
8895 | CPNE3 | GSM4909306 | Human | Breast | IDC | 2.91e-07 | 3.97e-01 | 0.1564 |
8895 | CPNE3 | GSM4909307 | Human | Breast | IDC | 1.28e-02 | 2.66e-01 | 0.1569 |
8895 | CPNE3 | GSM4909308 | Human | Breast | IDC | 5.91e-12 | 4.33e-01 | 0.158 |
8895 | CPNE3 | GSM4909311 | Human | Breast | IDC | 3.41e-18 | -8.34e-02 | 0.1534 |
8895 | CPNE3 | GSM4909312 | Human | Breast | IDC | 8.74e-09 | 1.54e-01 | 0.1552 |
8895 | CPNE3 | GSM4909317 | Human | Breast | IDC | 4.89e-12 | 4.53e-01 | 0.1355 |
8895 | CPNE3 | GSM4909319 | Human | Breast | IDC | 2.57e-21 | -9.18e-02 | 0.1563 |
8895 | CPNE3 | GSM4909321 | Human | Breast | IDC | 4.57e-07 | -2.55e-02 | 0.1559 |
8895 | CPNE3 | M1 | Human | Breast | IDC | 3.80e-04 | 3.52e-01 | 0.1577 |
8895 | CPNE3 | NCCBC14 | Human | Breast | DCIS | 1.94e-06 | 1.67e-01 | 0.2021 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001003814 | Breast | IDC | response to metal ion | 65/1434 | 373/18723 | 2.95e-10 | 3.42e-08 | 65 |
GO:007124813 | Breast | IDC | cellular response to metal ion | 27/1434 | 197/18723 | 2.28e-03 | 2.09e-02 | 27 |
GO:007124113 | Breast | IDC | cellular response to inorganic substance | 29/1434 | 226/18723 | 4.28e-03 | 3.34e-02 | 29 |
GO:005159213 | Breast | IDC | response to calcium ion | 21/1434 | 149/18723 | 4.79e-03 | 3.67e-02 | 21 |
GO:001003824 | Breast | DCIS | response to metal ion | 65/1390 | 373/18723 | 8.03e-11 | 9.88e-09 | 65 |
GO:007124822 | Breast | DCIS | cellular response to metal ion | 27/1390 | 197/18723 | 1.46e-03 | 1.49e-02 | 27 |
GO:007124123 | Breast | DCIS | cellular response to inorganic substance | 29/1390 | 226/18723 | 2.75e-03 | 2.41e-02 | 29 |
GO:005159223 | Breast | DCIS | response to calcium ion | 21/1390 | 149/18723 | 3.34e-03 | 2.81e-02 | 21 |
GO:003812717 | Esophagus | HGIN | ERBB signaling pathway | 29/2587 | 121/18723 | 1.83e-03 | 1.97e-02 | 29 |
GO:003812718 | Esophagus | ESCC | ERBB signaling pathway | 82/8552 | 121/18723 | 7.23e-07 | 9.40e-06 | 82 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:007124117 | Esophagus | ESCC | cellular response to inorganic substance | 125/8552 | 226/18723 | 2.17e-03 | 9.67e-03 | 125 |
GO:001003812 | Liver | Cirrhotic | response to metal ion | 150/4634 | 373/18723 | 2.27e-11 | 1.37e-09 | 150 |
GO:005159211 | Liver | Cirrhotic | response to calcium ion | 61/4634 | 149/18723 | 9.47e-06 | 1.38e-04 | 61 |
GO:00712487 | Liver | Cirrhotic | cellular response to metal ion | 73/4634 | 197/18723 | 7.73e-05 | 8.54e-04 | 73 |
GO:00712417 | Liver | Cirrhotic | cellular response to inorganic substance | 81/4634 | 226/18723 | 1.21e-04 | 1.20e-03 | 81 |
GO:003812711 | Liver | Cirrhotic | ERBB signaling pathway | 46/4634 | 121/18723 | 8.08e-04 | 5.93e-03 | 46 |
GO:001003822 | Liver | HCC | response to metal ion | 208/7958 | 373/18723 | 1.35e-07 | 2.56e-06 | 208 |
GO:003812721 | Liver | HCC | ERBB signaling pathway | 73/7958 | 121/18723 | 5.65e-05 | 5.26e-04 | 73 |
GO:007124112 | Liver | HCC | cellular response to inorganic substance | 119/7958 | 226/18723 | 1.26e-03 | 6.92e-03 | 119 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPNE3 | deletion | Frame_Shift_Del | rs761955273 | c.772delN | p.Ser260AlafsTer10 | p.S260Afs*10 | O75131 | protein_coding | TCGA-AP-A0LG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CPNE3 | deletion | Frame_Shift_Del | rs761955273 | c.772delN | p.Ser260AlafsTer10 | p.S260Afs*10 | O75131 | protein_coding | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | ||
CPNE3 | SNV | Missense_Mutation | novel | c.706N>G | p.Leu236Val | p.L236V | O75131 | protein_coding | deleterious(0.03) | benign(0.213) | TCGA-2Y-A9H3-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CPNE3 | SNV | Missense_Mutation | novel | c.1561N>G | p.Thr521Ala | p.T521A | O75131 | protein_coding | tolerated(0.59) | benign(0.001) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CPNE3 | SNV | Missense_Mutation | novel | c.1524N>T | p.Leu508Phe | p.L508F | O75131 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-99-8028-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CPNE3 | SNV | Missense_Mutation | novel | c.1525N>T | p.Ala509Ser | p.A509S | O75131 | protein_coding | deleterious(0.02) | probably_damaging(0.968) | TCGA-99-8028-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CPNE3 | SNV | Missense_Mutation | c.207N>A | p.Phe69Leu | p.F69L | O75131 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-L9-A743-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | taxotere | CR | |
CPNE3 | SNV | Missense_Mutation | rs376221396 | c.140N>A | p.Arg47His | p.R47H | O75131 | protein_coding | deleterious(0.04) | possibly_damaging(0.751) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CPNE3 | SNV | Missense_Mutation | rs781107778 | c.535N>T | p.Arg179Trp | p.R179W | O75131 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPNE3 | SNV | Missense_Mutation | novel | c.1393N>C | p.Glu465Gln | p.E465Q | O75131 | protein_coding | tolerated(0.29) | probably_damaging(1) | TCGA-43-5670-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxotere | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |