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Gene: COPS3 |
Gene summary for COPS3 |
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Gene information | Species | Human | Gene symbol | COPS3 | Gene ID | 8533 |
Gene name | COP9 signalosome subunit 3 | |
Gene Alias | CSN3 | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000338 | UniProtAcc | Q9UNS2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8533 | COPS3 | LZE4T | Human | Esophagus | ESCC | 7.38e-17 | 5.02e-01 | 0.0811 |
8533 | COPS3 | LZE7T | Human | Esophagus | ESCC | 8.90e-06 | 7.10e-01 | 0.0667 |
8533 | COPS3 | LZE8T | Human | Esophagus | ESCC | 4.59e-10 | 2.02e-01 | 0.067 |
8533 | COPS3 | LZE20T | Human | Esophagus | ESCC | 8.39e-04 | -1.79e-02 | 0.0662 |
8533 | COPS3 | LZE22D1 | Human | Esophagus | HGIN | 4.62e-05 | -4.91e-02 | 0.0595 |
8533 | COPS3 | LZE24T | Human | Esophagus | ESCC | 9.34e-20 | 7.70e-01 | 0.0596 |
8533 | COPS3 | LZE21T | Human | Esophagus | ESCC | 1.03e-02 | 2.41e-01 | 0.0655 |
8533 | COPS3 | LZE6T | Human | Esophagus | ESCC | 5.78e-07 | 4.72e-01 | 0.0845 |
8533 | COPS3 | P1T-E | Human | Esophagus | ESCC | 9.36e-05 | 3.02e-01 | 0.0875 |
8533 | COPS3 | P2T-E | Human | Esophagus | ESCC | 1.50e-24 | 7.46e-01 | 0.1177 |
8533 | COPS3 | P4T-E | Human | Esophagus | ESCC | 4.99e-39 | 1.13e+00 | 0.1323 |
8533 | COPS3 | P5T-E | Human | Esophagus | ESCC | 9.43e-17 | 2.62e-01 | 0.1327 |
8533 | COPS3 | P8T-E | Human | Esophagus | ESCC | 1.90e-20 | 6.00e-01 | 0.0889 |
8533 | COPS3 | P9T-E | Human | Esophagus | ESCC | 2.50e-15 | 3.87e-01 | 0.1131 |
8533 | COPS3 | P10T-E | Human | Esophagus | ESCC | 3.94e-29 | 6.14e-01 | 0.116 |
8533 | COPS3 | P11T-E | Human | Esophagus | ESCC | 3.51e-12 | 7.14e-01 | 0.1426 |
8533 | COPS3 | P12T-E | Human | Esophagus | ESCC | 4.56e-34 | 8.23e-01 | 0.1122 |
8533 | COPS3 | P15T-E | Human | Esophagus | ESCC | 9.16e-27 | 5.10e-01 | 0.1149 |
8533 | COPS3 | P16T-E | Human | Esophagus | ESCC | 7.77e-34 | 8.72e-01 | 0.1153 |
8533 | COPS3 | P17T-E | Human | Esophagus | ESCC | 1.95e-11 | 5.44e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170118 | Esophagus | HGIN | in utero embryonic development | 77/2587 | 367/18723 | 9.56e-05 | 2.05e-03 | 77 |
GO:000931418 | Esophagus | HGIN | response to radiation | 88/2587 | 456/18723 | 6.26e-04 | 8.65e-03 | 88 |
GO:00003383 | Esophagus | HGIN | protein deneddylation | 6/2587 | 10/18723 | 8.81e-04 | 1.13e-02 | 6 |
GO:00706463 | Esophagus | HGIN | protein modification by small protein removal | 34/2587 | 157/18723 | 4.68e-03 | 4.02e-02 | 34 |
GO:00094165 | Esophagus | HGIN | response to light stimulus | 61/2587 | 320/18723 | 5.20e-03 | 4.30e-02 | 61 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:000033812 | Esophagus | ESCC | protein deneddylation | 10/8552 | 10/18723 | 3.94e-04 | 2.26e-03 | 10 |
GO:00017015 | Liver | Cirrhotic | in utero embryonic development | 134/4634 | 367/18723 | 2.78e-07 | 6.86e-06 | 134 |
GO:0000338 | Liver | Cirrhotic | protein deneddylation | 7/4634 | 10/18723 | 3.29e-03 | 1.83e-02 | 7 |
GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:00003381 | Liver | HCC | protein deneddylation | 9/7958 | 10/18723 | 2.79e-03 | 1.31e-02 | 9 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
GO:000170116 | Oral cavity | OSCC | in utero embryonic development | 207/7305 | 367/18723 | 7.92e-12 | 2.95e-10 | 207 |
GO:000931416 | Oral cavity | OSCC | response to radiation | 241/7305 | 456/18723 | 9.76e-10 | 2.40e-08 | 241 |
GO:00094164 | Oral cavity | OSCC | response to light stimulus | 159/7305 | 320/18723 | 5.98e-05 | 4.92e-04 | 159 |
GO:00003382 | Oral cavity | OSCC | protein deneddylation | 10/7305 | 10/18723 | 8.14e-05 | 6.26e-04 | 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COPS3 | SNV | Missense_Mutation | novel | c.95N>T | p.Gly32Val | p.G32V | Q9UNS2 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-05-4417-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COPS3 | SNV | Missense_Mutation | c.1081C>T | p.His361Tyr | p.H361Y | Q9UNS2 | protein_coding | tolerated(0.06) | benign(0.125) | TCGA-49-4487-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
COPS3 | SNV | Missense_Mutation | c.1159N>A | p.Asp387Asn | p.D387N | Q9UNS2 | protein_coding | tolerated(0.37) | benign(0.001) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
COPS3 | SNV | Missense_Mutation | c.433N>G | p.Leu145Val | p.L145V | Q9UNS2 | protein_coding | deleterious(0.05) | benign(0.411) | TCGA-55-6972-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
COPS3 | SNV | Missense_Mutation | novel | c.502G>C | p.Asp168His | p.D168H | Q9UNS2 | protein_coding | tolerated(0.06) | benign(0.212) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
COPS3 | SNV | Missense_Mutation | novel | c.1162G>A | p.Glu388Lys | p.E388K | Q9UNS2 | protein_coding | tolerated(0.92) | benign(0) | TCGA-63-A5MW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COPS3 | insertion | Frame_Shift_Ins | novel | c.421dupA | p.Ile141AsnfsTer4 | p.I141Nfs*4 | Q9UNS2 | protein_coding | TCGA-96-A4JK-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR | ||
COPS3 | SNV | Missense_Mutation | novel | c.1207T>C | p.Phe403Leu | p.F403L | Q9UNS2 | protein_coding | deleterious(0.03) | possibly_damaging(0.489) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COPS3 | SNV | Missense_Mutation | rs773256226 | c.107N>T | p.Ala36Val | p.A36V | Q9UNS2 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COPS3 | SNV | Missense_Mutation | novel | c.1063N>A | p.Asp355Asn | p.D355N | Q9UNS2 | protein_coding | deleterious(0.03) | possibly_damaging(0.728) | TCGA-VQ-A8DU-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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