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Gene: COG8 |
Gene summary for COG8 |
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Gene information | Species | Human | Gene symbol | COG8 | Gene ID | 84342 |
Gene name | component of oligomeric golgi complex 8 | |
Gene Alias | CDG2H | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R6Z6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84342 | COG8 | LZE4T | Human | Esophagus | ESCC | 7.39e-03 | 9.99e-02 | 0.0811 |
84342 | COG8 | LZE7T | Human | Esophagus | ESCC | 2.14e-03 | 2.00e-01 | 0.0667 |
84342 | COG8 | LZE24T | Human | Esophagus | ESCC | 7.50e-09 | 1.60e-01 | 0.0596 |
84342 | COG8 | P1T-E | Human | Esophagus | ESCC | 1.68e-03 | 3.34e-01 | 0.0875 |
84342 | COG8 | P2T-E | Human | Esophagus | ESCC | 4.07e-18 | 1.29e-01 | 0.1177 |
84342 | COG8 | P4T-E | Human | Esophagus | ESCC | 5.72e-12 | 2.85e-01 | 0.1323 |
84342 | COG8 | P5T-E | Human | Esophagus | ESCC | 4.25e-12 | 1.37e-01 | 0.1327 |
84342 | COG8 | P8T-E | Human | Esophagus | ESCC | 1.91e-19 | 1.84e-01 | 0.0889 |
84342 | COG8 | P9T-E | Human | Esophagus | ESCC | 2.59e-03 | 9.04e-02 | 0.1131 |
84342 | COG8 | P10T-E | Human | Esophagus | ESCC | 1.13e-11 | 1.46e-01 | 0.116 |
84342 | COG8 | P11T-E | Human | Esophagus | ESCC | 3.48e-12 | 3.18e-01 | 0.1426 |
84342 | COG8 | P12T-E | Human | Esophagus | ESCC | 9.18e-13 | 2.08e-01 | 0.1122 |
84342 | COG8 | P15T-E | Human | Esophagus | ESCC | 1.38e-05 | 1.49e-01 | 0.1149 |
84342 | COG8 | P16T-E | Human | Esophagus | ESCC | 2.53e-14 | 1.82e-01 | 0.1153 |
84342 | COG8 | P17T-E | Human | Esophagus | ESCC | 2.20e-06 | 2.38e-01 | 0.1278 |
84342 | COG8 | P19T-E | Human | Esophagus | ESCC | 1.78e-02 | 2.19e-01 | 0.1662 |
84342 | COG8 | P20T-E | Human | Esophagus | ESCC | 1.00e-12 | 2.25e-01 | 0.1124 |
84342 | COG8 | P21T-E | Human | Esophagus | ESCC | 8.28e-12 | 2.11e-01 | 0.1617 |
84342 | COG8 | P22T-E | Human | Esophagus | ESCC | 7.82e-13 | 2.45e-01 | 0.1236 |
84342 | COG8 | P23T-E | Human | Esophagus | ESCC | 5.51e-22 | 5.06e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:00068914 | Esophagus | ESCC | intra-Golgi vesicle-mediated transport | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:00068913 | Oral cavity | OSCC | intra-Golgi vesicle-mediated transport | 23/7305 | 33/18723 | 3.47e-04 | 2.12e-03 | 23 |
GO:004819316 | Oral cavity | LP | Golgi vesicle transport | 141/4623 | 296/18723 | 6.11e-18 | 1.06e-15 | 141 |
GO:000689111 | Oral cavity | LP | intra-Golgi vesicle-mediated transport | 16/4623 | 33/18723 | 2.59e-03 | 1.83e-02 | 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COG8 | SNV | Missense_Mutation | novel | c.1516N>T | p.Leu506Phe | p.L506F | Q96MW5 | protein_coding | deleterious(0.03) | benign(0.105) | TCGA-KB-A93G-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COG8 | SNV | Missense_Mutation | novel | c.980N>C | p.Leu327Pro | p.L327P | Q96MW5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
COG8 | insertion | Frame_Shift_Ins | novel | c.1607dupA | p.Tyr537ValfsTer3 | p.Y537Vfs*3 | Q96MW5 | protein_coding | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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