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Gene: CNPPD1 |
Gene summary for CNPPD1 |
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Gene information | Species | Human | Gene symbol | CNPPD1 | Gene ID | 27013 |
Gene name | cyclin Pas1/PHO80 domain containing 1 | |
Gene Alias | C2orf24 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000079 | UniProtAcc | A0A024R432 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27013 | CNPPD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.43e-13 | 3.22e-01 | 0.0155 |
27013 | CNPPD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.67e-18 | 6.51e-01 | -0.1808 |
27013 | CNPPD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.04e-23 | 8.18e-01 | -0.0811 |
27013 | CNPPD1 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.28e-23 | 6.01e-01 | -0.1088 |
27013 | CNPPD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.32e-47 | 8.71e-01 | -0.1954 |
27013 | CNPPD1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.59e-16 | 1.19e+00 | -0.2602 |
27013 | CNPPD1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.87e-09 | 6.54e-01 | -0.2196 |
27013 | CNPPD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.89e-22 | 6.90e-01 | -0.1207 |
27013 | CNPPD1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.40e-14 | 6.77e-01 | -0.1526 |
27013 | CNPPD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.45e-37 | 7.73e-01 | -0.1464 |
27013 | CNPPD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.06e-24 | 5.02e-01 | -0.1001 |
27013 | CNPPD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.93e-25 | 7.47e-01 | -0.059 |
27013 | CNPPD1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.08e-07 | 5.94e-01 | -0.1706 |
27013 | CNPPD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.57e-16 | 8.78e-01 | -0.2061 |
27013 | CNPPD1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.50e-07 | 6.88e-01 | -0.1462 |
27013 | CNPPD1 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.83e-09 | 4.77e-01 | -0.0842 |
27013 | CNPPD1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.52e-13 | 6.25e-01 | -0.0179 |
27013 | CNPPD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.44e-20 | 5.21e-01 | 0.096 |
27013 | CNPPD1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.20e-04 | 3.93e-01 | 0.0528 |
27013 | CNPPD1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.32e-05 | 4.02e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0071900 | Colorectum | AD | regulation of protein serine/threonine kinase activity | 98/3918 | 359/18723 | 2.18e-03 | 1.73e-02 | 98 |
GO:00719001 | Colorectum | SER | regulation of protein serine/threonine kinase activity | 74/2897 | 359/18723 | 5.22e-03 | 3.96e-02 | 74 |
GO:00719002 | Colorectum | MSS | regulation of protein serine/threonine kinase activity | 93/3467 | 359/18723 | 2.98e-04 | 3.91e-03 | 93 |
GO:007190016 | Esophagus | ESCC | regulation of protein serine/threonine kinase activity | 227/8552 | 359/18723 | 1.12e-11 | 4.10e-10 | 227 |
GO:19040294 | Esophagus | ESCC | regulation of cyclin-dependent protein kinase activity | 69/8552 | 98/18723 | 6.04e-07 | 7.91e-06 | 69 |
GO:00000794 | Esophagus | ESCC | regulation of cyclin-dependent protein serine/threonine kinase activity | 66/8552 | 94/18723 | 1.24e-06 | 1.53e-05 | 66 |
GO:007190011 | Liver | Cirrhotic | regulation of protein serine/threonine kinase activity | 110/4634 | 359/18723 | 6.19e-03 | 3.08e-02 | 110 |
GO:007190021 | Liver | HCC | regulation of protein serine/threonine kinase activity | 189/7958 | 359/18723 | 5.97e-05 | 5.47e-04 | 189 |
GO:0000079 | Liver | HCC | regulation of cyclin-dependent protein serine/threonine kinase activity | 55/7958 | 94/18723 | 1.25e-03 | 6.91e-03 | 55 |
GO:1904029 | Liver | HCC | regulation of cyclin-dependent protein kinase activity | 57/7958 | 98/18723 | 1.26e-03 | 6.92e-03 | 57 |
GO:007190010 | Oral cavity | OSCC | regulation of protein serine/threonine kinase activity | 201/7305 | 359/18723 | 3.90e-11 | 1.27e-09 | 201 |
GO:19040293 | Oral cavity | OSCC | regulation of cyclin-dependent protein kinase activity | 60/7305 | 98/18723 | 6.90e-06 | 7.56e-05 | 60 |
GO:00000793 | Oral cavity | OSCC | regulation of cyclin-dependent protein serine/threonine kinase activity | 58/7305 | 94/18723 | 6.92e-06 | 7.57e-05 | 58 |
GO:007190015 | Oral cavity | LP | regulation of protein serine/threonine kinase activity | 119/4623 | 359/18723 | 1.70e-04 | 1.90e-03 | 119 |
GO:000007911 | Oral cavity | LP | regulation of cyclin-dependent protein serine/threonine kinase activity | 34/4623 | 94/18723 | 8.52e-03 | 4.61e-02 | 34 |
GO:00000795 | Skin | cSCC | regulation of cyclin-dependent protein serine/threonine kinase activity | 41/4864 | 94/18723 | 1.53e-04 | 1.35e-03 | 41 |
GO:190402911 | Skin | cSCC | regulation of cyclin-dependent protein kinase activity | 42/4864 | 98/18723 | 2.05e-04 | 1.70e-03 | 42 |
GO:007190024 | Skin | cSCC | regulation of protein serine/threonine kinase activity | 123/4864 | 359/18723 | 2.70e-04 | 2.17e-03 | 123 |
GO:0071900110 | Thyroid | PTC | regulation of protein serine/threonine kinase activity | 164/5968 | 359/18723 | 2.41e-08 | 5.43e-07 | 164 |
GO:190402912 | Thyroid | PTC | regulation of cyclin-dependent protein kinase activity | 49/5968 | 98/18723 | 1.40e-04 | 1.09e-03 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNPPD1 | SNV | Missense_Mutation | novel | c.1202C>A | p.Ala401Asp | p.A401D | Q9BV87 | protein_coding | tolerated_low_confidence(0.14) | benign(0.298) | TCGA-IN-A6RO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | PD |
CNPPD1 | SNV | Missense_Mutation | novel | c.247N>A | p.Ala83Thr | p.A83T | Q9BV87 | protein_coding | deleterious(0.01) | possibly_damaging(0.515) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
CNPPD1 | insertion | Frame_Shift_Ins | rs764842458 | c.1128_1129insC | p.Trp377LeufsTer50 | p.W377Lfs*50 | Q9BV87 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
CNPPD1 | insertion | Frame_Shift_Ins | novel | c.1048_1049insTCTTA | p.His350LeufsTer65 | p.H350Lfs*65 | Q9BV87 | protein_coding | TCGA-FY-A40L-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | levothyroxine | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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