|
Gene: CLVS1 |
Gene summary for CLVS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CLVS1 | Gene ID | 157807 |
Gene name | clavesin 1 | |
Gene Alias | C6orf212L | |
Cytomap | 8q12.2-q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q8IUQ0 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
157807 | CLVS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.07e-52 | 9.87e-01 | 0.0155 |
157807 | CLVS1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.30e-15 | 8.46e-01 | -0.1808 |
157807 | CLVS1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.94e-06 | 6.25e-01 | 0.0216 |
157807 | CLVS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.49e-29 | 1.33e+00 | -0.0811 |
157807 | CLVS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.46e-58 | 1.80e+00 | -0.1088 |
157807 | CLVS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.54e-41 | 1.18e+00 | -0.1954 |
157807 | CLVS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.10e-07 | 6.28e-01 | -0.1207 |
157807 | CLVS1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.72e-10 | 6.68e-01 | -0.1526 |
157807 | CLVS1 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.25e-23 | 6.08e-01 | -0.1464 |
157807 | CLVS1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.28e-10 | 3.98e-01 | -0.1001 |
157807 | CLVS1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.52e-28 | 1.08e+00 | -0.059 |
157807 | CLVS1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.16e-10 | 8.68e-01 | -0.1706 |
157807 | CLVS1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.01e-11 | 7.80e-01 | -0.2061 |
157807 | CLVS1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 5.23e-04 | 5.35e-01 | -0.1462 |
157807 | CLVS1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.29e-08 | 5.28e-01 | -0.0842 |
157807 | CLVS1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.33e-23 | 1.19e+00 | -0.0179 |
157807 | CLVS1 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.09e-62 | 1.46e+00 | 0.096 |
157807 | CLVS1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.11e-17 | 1.44e+00 | 0.0446 |
157807 | CLVS1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.23e-27 | 1.34e+00 | 0.0528 |
157807 | CLVS1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.39e-17 | 1.00e+00 | 0.0131 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007033 | Colorectum | AD | vacuole organization | 53/3918 | 180/18723 | 4.18e-03 | 2.89e-02 | 53 |
GO:00070331 | Colorectum | MSS | vacuole organization | 48/3467 | 180/18723 | 4.32e-03 | 3.07e-02 | 48 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLVS1 | SNV | Missense_Mutation | novel | c.450N>T | p.Gln150His | p.Q150H | Q8IUQ0 | protein_coding | tolerated(0.53) | probably_damaging(0.926) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CLVS1 | SNV | Missense_Mutation | novel | c.691N>T | p.Ala231Ser | p.A231S | Q8IUQ0 | protein_coding | tolerated(0.11) | possibly_damaging(0.542) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CLVS1 | SNV | Missense_Mutation | c.905N>A | p.Ser302Tyr | p.S302Y | Q8IUQ0 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-51-4080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CLVS1 | SNV | Missense_Mutation | rs202238473 | c.479G>A | p.Arg160His | p.R160H | Q8IUQ0 | protein_coding | deleterious(0.04) | probably_damaging(0.993) | TCGA-56-A4BW-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
CLVS1 | SNV | Missense_Mutation | rs766720972 | c.196A>G | p.Ile66Val | p.I66V | Q8IUQ0 | protein_coding | tolerated(0.17) | possibly_damaging(0.656) | TCGA-56-A4BX-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | chemo | CR |
CLVS1 | SNV | Missense_Mutation | novel | c.283G>A | p.Ala95Thr | p.A95T | Q8IUQ0 | protein_coding | tolerated(0.16) | benign(0.27) | TCGA-60-2714-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
CLVS1 | SNV | Missense_Mutation | c.369N>G | p.Ile123Met | p.I123M | Q8IUQ0 | protein_coding | tolerated(0.19) | benign(0.005) | TCGA-60-2720-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
CLVS1 | SNV | Missense_Mutation | c.304N>A | p.Gln102Lys | p.Q102K | Q8IUQ0 | protein_coding | tolerated(0.34) | benign(0.024) | TCGA-60-2726-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CLVS1 | SNV | Missense_Mutation | c.505N>A | p.Leu169Ile | p.L169I | Q8IUQ0 | protein_coding | deleterious(0.01) | benign(0.386) | TCGA-85-6798-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD | |
CLVS1 | SNV | Missense_Mutation | novel | c.448C>A | p.Gln150Lys | p.Q150K | Q8IUQ0 | protein_coding | tolerated(0.28) | possibly_damaging(0.597) | TCGA-85-7697-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |