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Gene: CLINT1 |
Gene summary for CLINT1 |
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Gene information | Species | Human | Gene symbol | CLINT1 | Gene ID | 9685 |
Gene name | clathrin interactor 1 | |
Gene Alias | CLINT | |
Cytomap | 5q33.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A0S2Z5H3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9685 | CLINT1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.78e-18 | -6.39e-01 | 0.0155 |
9685 | CLINT1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.36e-05 | -5.34e-01 | -0.1207 |
9685 | CLINT1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.73e-11 | -4.75e-01 | 0.0674 |
9685 | CLINT1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.19e-05 | -3.11e-01 | 0.3859 |
9685 | CLINT1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.75e-25 | -6.28e-01 | 0.3005 |
9685 | CLINT1 | F007 | Human | Colorectum | FAP | 6.01e-11 | -6.55e-01 | 0.1176 |
9685 | CLINT1 | A002-C-010 | Human | Colorectum | FAP | 1.47e-08 | -3.67e-01 | 0.242 |
9685 | CLINT1 | A001-C-207 | Human | Colorectum | FAP | 3.39e-12 | -5.72e-01 | 0.1278 |
9685 | CLINT1 | A015-C-203 | Human | Colorectum | FAP | 8.99e-41 | -6.41e-01 | -0.1294 |
9685 | CLINT1 | A015-C-204 | Human | Colorectum | FAP | 5.44e-14 | -5.73e-01 | -0.0228 |
9685 | CLINT1 | A014-C-040 | Human | Colorectum | FAP | 1.37e-08 | -6.69e-01 | -0.1184 |
9685 | CLINT1 | A002-C-201 | Human | Colorectum | FAP | 1.59e-20 | -5.64e-01 | 0.0324 |
9685 | CLINT1 | A002-C-203 | Human | Colorectum | FAP | 7.49e-09 | -3.09e-01 | 0.2786 |
9685 | CLINT1 | A001-C-119 | Human | Colorectum | FAP | 5.96e-13 | -6.12e-01 | -0.1557 |
9685 | CLINT1 | A001-C-108 | Human | Colorectum | FAP | 4.13e-26 | -4.84e-01 | -0.0272 |
9685 | CLINT1 | A002-C-205 | Human | Colorectum | FAP | 1.05e-29 | -6.20e-01 | -0.1236 |
9685 | CLINT1 | A001-C-104 | Human | Colorectum | FAP | 7.21e-08 | -3.35e-01 | 0.0184 |
9685 | CLINT1 | A015-C-005 | Human | Colorectum | FAP | 1.75e-06 | -3.64e-01 | -0.0336 |
9685 | CLINT1 | A015-C-006 | Human | Colorectum | FAP | 5.68e-20 | -6.48e-01 | -0.0994 |
9685 | CLINT1 | A015-C-106 | Human | Colorectum | FAP | 3.77e-19 | -4.54e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048268 | Colorectum | AD | clathrin coat assembly | 10/3918 | 18/18723 | 1.31e-03 | 1.15e-02 | 10 |
GO:00482681 | Colorectum | MSS | clathrin coat assembly | 10/3467 | 18/18723 | 4.76e-04 | 5.58e-03 | 10 |
GO:00482682 | Colorectum | FAP | clathrin coat assembly | 8/2622 | 18/18723 | 1.72e-03 | 1.51e-02 | 8 |
GO:00482683 | Colorectum | CRC | clathrin coat assembly | 7/2078 | 18/18723 | 2.16e-03 | 2.11e-02 | 7 |
GO:00482689 | Oral cavity | EOLP | clathrin coat assembly | 8/2218 | 18/18723 | 5.58e-04 | 4.74e-03 | 8 |
GO:004826813 | Oral cavity | NEOLP | clathrin coat assembly | 9/2005 | 18/18723 | 3.59e-05 | 5.21e-04 | 9 |
GO:00482688 | Prostate | BPH | clathrin coat assembly | 10/3107 | 18/18723 | 1.87e-04 | 1.55e-03 | 10 |
GO:004826812 | Prostate | Tumor | clathrin coat assembly | 10/3246 | 18/18723 | 2.72e-04 | 2.24e-03 | 10 |
GO:004826810 | Skin | AK | clathrin coat assembly | 6/1910 | 18/18723 | 7.04e-03 | 3.63e-02 | 6 |
GO:004826814 | Skin | cSCC | clathrin coat assembly | 10/4864 | 18/18723 | 7.25e-03 | 3.44e-02 | 10 |
GO:004826815 | Thyroid | PTC | clathrin coat assembly | 12/5968 | 18/18723 | 2.55e-03 | 1.31e-02 | 12 |
GO:004826816 | Thyroid | ATC | clathrin coat assembly | 12/6293 | 18/18723 | 4.22e-03 | 1.79e-02 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLINT1 | SNV | Missense_Mutation | novel | c.309N>C | p.Glu103Asp | p.E103D | Q14677 | protein_coding | deleterious(0) | possibly_damaging(0.506) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLINT1 | SNV | Missense_Mutation | novel | c.754N>T | p.Asp252Tyr | p.D252Y | Q14677 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CLINT1 | insertion | Frame_Shift_Ins | novel | c.1391_1392insA | p.Asn464LysfsTer3 | p.N464Kfs*3 | Q14677 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CLINT1 | SNV | Missense_Mutation | rs201922408 | c.1763N>T | p.Pro588Leu | p.P588L | Q14677 | protein_coding | deleterious(0.03) | benign(0) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CLINT1 | SNV | Missense_Mutation | c.1294N>A | p.Ala432Thr | p.A432T | Q14677 | protein_coding | tolerated(1) | benign(0) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CLINT1 | SNV | Missense_Mutation | c.1249G>T | p.Ala417Ser | p.A417S | Q14677 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-55-5899-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
CLINT1 | SNV | Missense_Mutation | c.1452N>C | p.Gln484His | p.Q484H | Q14677 | protein_coding | tolerated(0.08) | possibly_damaging(0.45) | TCGA-55-A491-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLINT1 | SNV | Missense_Mutation | c.1533G>T | p.Met511Ile | p.M511I | Q14677 | protein_coding | deleterious(0.04) | benign(0.03) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CLINT1 | SNV | Missense_Mutation | rs758692113 | c.1780N>T | p.Met594Leu | p.M594L | Q14677 | protein_coding | tolerated(0.21) | benign(0) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CLINT1 | SNV | Missense_Mutation | novel | c.1364N>G | p.Pro455Arg | p.P455R | Q14677 | protein_coding | deleterious(0) | possibly_damaging(0.646) | TCGA-LA-A7SW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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