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Gene: CFH |
Gene summary for CFH |
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Gene information | Species | Human | Gene symbol | CFH | Gene ID | 3075 |
Gene name | complement factor H | |
Gene Alias | AHUS1 | |
Cytomap | 1q31.3 | |
Gene Type | protein-coding | GO ID | GO:0001906 | UniProtAcc | A0A024R962 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3075 | CFH | LZE2T | Human | Esophagus | ESCC | 2.70e-07 | 6.21e-02 | 0.082 |
3075 | CFH | LZE8T | Human | Esophagus | ESCC | 2.89e-04 | 4.36e-01 | 0.067 |
3075 | CFH | P2T-E | Human | Esophagus | ESCC | 2.11e-10 | 1.04e-01 | 0.1177 |
3075 | CFH | P8T-E | Human | Esophagus | ESCC | 2.67e-26 | 8.39e-01 | 0.0889 |
3075 | CFH | P10T-E | Human | Esophagus | ESCC | 1.48e-07 | -3.13e-01 | 0.116 |
3075 | CFH | P11T-E | Human | Esophagus | ESCC | 3.47e-03 | 6.55e-01 | 0.1426 |
3075 | CFH | P12T-E | Human | Esophagus | ESCC | 4.81e-05 | -3.66e-01 | 0.1122 |
3075 | CFH | P16T-E | Human | Esophagus | ESCC | 3.28e-09 | -2.37e-01 | 0.1153 |
3075 | CFH | P22T-E | Human | Esophagus | ESCC | 2.63e-04 | -2.06e-01 | 0.1236 |
3075 | CFH | P24T-E | Human | Esophagus | ESCC | 1.73e-09 | 9.85e-02 | 0.1287 |
3075 | CFH | P28T-E | Human | Esophagus | ESCC | 4.75e-09 | -3.07e-01 | 0.1149 |
3075 | CFH | P31T-E | Human | Esophagus | ESCC | 5.47e-05 | -3.57e-01 | 0.1251 |
3075 | CFH | P32T-E | Human | Esophagus | ESCC | 4.23e-07 | 4.88e-01 | 0.1666 |
3075 | CFH | P36T-E | Human | Esophagus | ESCC | 2.22e-04 | 6.35e-01 | 0.1187 |
3075 | CFH | P37T-E | Human | Esophagus | ESCC | 3.49e-03 | 2.56e-01 | 0.1371 |
3075 | CFH | P39T-E | Human | Esophagus | ESCC | 3.12e-02 | -2.57e-01 | 0.0894 |
3075 | CFH | P40T-E | Human | Esophagus | ESCC | 3.27e-02 | -2.33e-02 | 0.109 |
3075 | CFH | P42T-E | Human | Esophagus | ESCC | 1.41e-03 | 3.94e-01 | 0.1175 |
3075 | CFH | P54T-E | Human | Esophagus | ESCC | 4.95e-10 | 5.27e-01 | 0.0975 |
3075 | CFH | P57T-E | Human | Esophagus | ESCC | 8.01e-10 | 4.49e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030449 | Liver | NAFLD | regulation of complement activation | 8/1882 | 21/18723 | 6.29e-04 | 8.21e-03 | 8 |
GO:00972783 | Liver | NAFLD | complement-dependent cytotoxicity | 5/1882 | 10/18723 | 1.67e-03 | 1.74e-02 | 5 |
GO:004440312 | Liver | Cirrhotic | biological process involved in symbiotic interaction | 131/4634 | 290/18723 | 2.00e-14 | 1.84e-12 | 131 |
GO:005109812 | Liver | Cirrhotic | regulation of binding | 148/4634 | 363/18723 | 9.14e-12 | 5.97e-10 | 148 |
GO:005170211 | Liver | Cirrhotic | biological process involved in interaction with symbiont | 48/4634 | 94/18723 | 3.41e-08 | 1.14e-06 | 48 |
GO:004339312 | Liver | Cirrhotic | regulation of protein binding | 83/4634 | 196/18723 | 4.44e-08 | 1.42e-06 | 83 |
GO:00511006 | Liver | Cirrhotic | negative regulation of binding | 63/4634 | 162/18723 | 4.54e-05 | 5.31e-04 | 63 |
GO:00320914 | Liver | Cirrhotic | negative regulation of protein binding | 40/4634 | 94/18723 | 1.14e-04 | 1.14e-03 | 40 |
GO:0019835 | Liver | Cirrhotic | cytolysis | 17/4634 | 32/18723 | 5.24e-04 | 4.14e-03 | 17 |
GO:005109822 | Liver | HCC | regulation of binding | 225/7958 | 363/18723 | 3.78e-14 | 2.37e-12 | 225 |
GO:004440322 | Liver | HCC | biological process involved in symbiotic interaction | 183/7958 | 290/18723 | 9.13e-13 | 4.59e-11 | 183 |
GO:004339322 | Liver | HCC | regulation of protein binding | 129/7958 | 196/18723 | 3.27e-11 | 1.26e-09 | 129 |
GO:00517022 | Liver | HCC | biological process involved in interaction with symbiont | 60/7958 | 94/18723 | 2.41e-05 | 2.54e-04 | 60 |
GO:005110012 | Liver | HCC | negative regulation of binding | 94/7958 | 162/18723 | 4.69e-05 | 4.50e-04 | 94 |
GO:003209112 | Liver | HCC | negative regulation of protein binding | 59/7958 | 94/18723 | 5.79e-05 | 5.34e-04 | 59 |
GO:000225313 | Oral cavity | NEOLP | activation of immune response | 55/2005 | 375/18723 | 9.87e-03 | 4.62e-02 | 55 |
GO:00022535 | Skin | AK | activation of immune response | 54/1910 | 375/18723 | 5.90e-03 | 3.20e-02 | 54 |
GO:000225314 | Skin | SCCIS | activation of immune response | 33/919 | 375/18723 | 8.93e-04 | 1.15e-02 | 33 |
GO:00022536 | Thyroid | HT | activation of immune response | 47/1272 | 375/18723 | 3.55e-05 | 7.40e-04 | 47 |
GO:00069564 | Thyroid | HT | complement activation | 22/1272 | 130/18723 | 6.17e-05 | 1.16e-03 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04610 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046101 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046102 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046103 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046104 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa046105 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFH | SNV | Missense_Mutation | novel | c.3538N>A | p.Ala1180Thr | p.A1180T | P08603 | protein_coding | tolerated(0.66) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CFH | SNV | Missense_Mutation | c.1852N>A | p.Pro618Thr | p.P618T | P08603 | protein_coding | tolerated(0.09) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFH | SNV | Missense_Mutation | c.3355N>A | p.Asp1119Asn | p.D1119N | P08603 | protein_coding | deleterious(0.03) | possibly_damaging(0.543) | TCGA-AA-A02Y-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CFH | SNV | Missense_Mutation | c.3554C>G | p.Ala1185Gly | p.A1185G | P08603 | protein_coding | tolerated(0.42) | benign(0.066) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
CFH | SNV | Missense_Mutation | c.2035A>C | p.Thr679Pro | p.T679P | P08603 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CFH | SNV | Missense_Mutation | c.1669N>C | p.Gly557Arg | p.G557R | P08603 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6606-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfiri | PD | |
CFH | SNV | Missense_Mutation | rs767435695 | c.1688N>C | p.Ile563Thr | p.I563T | P08603 | protein_coding | tolerated(1) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CFH | SNV | Missense_Mutation | rs76405615 | c.1708N>A | p.Glu570Lys | p.E570K | P08603 | protein_coding | tolerated(0.79) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CFH | SNV | Missense_Mutation | c.20T>C | p.Ile7Thr | p.I7T | P08603 | protein_coding | deleterious(0.02) | possibly_damaging(0.487) | TCGA-CK-4950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folfox | SD | |
CFH | SNV | Missense_Mutation | c.3431T>G | p.Leu1144Arg | p.L1144R | P08603 | protein_coding | deleterious(0.03) | probably_damaging(0.915) | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3075 | CFH | DRUGGABLE GENOME | photodynamic therapy | 26780119,18292785,18050121 | ||
3075 | CFH | DRUGGABLE GENOME | TT-30 | |||
3075 | CFH | DRUGGABLE GENOME | eculizumab | ECULIZUMAB | 26724167 | |
3075 | CFH | DRUGGABLE GENOME | ranibizumab | RANIBIZUMAB | 26439641,23584701,23204795,22840423,22594510,23559864,24070809,26411831,23842101,23337555 | |
3075 | CFH | DRUGGABLE GENOME | Trumenba | |||
3075 | CFH | DRUGGABLE GENOME | bevacizumab | BEVACIZUMAB | 26439641,23584701,23204795,22840423,22594510,23559864,24070809,26411831,23842101,23337555 |
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