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Gene: CELSR2 |
Gene summary for CELSR2 |
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Gene information | Species | Human | Gene symbol | CELSR2 | Gene ID | 1952 |
Gene name | cadherin EGF LAG seven-pass G-type receptor 2 | |
Gene Alias | ADGRC2 | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9HCU4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1952 | CELSR2 | LZE2T | Human | Esophagus | ESCC | 2.58e-02 | 3.32e-01 | 0.082 |
1952 | CELSR2 | LZE20T | Human | Esophagus | ESCC | 1.21e-02 | 1.46e-01 | 0.0662 |
1952 | CELSR2 | LZE24T | Human | Esophagus | ESCC | 3.25e-04 | 2.30e-02 | 0.0596 |
1952 | CELSR2 | P1T-E | Human | Esophagus | ESCC | 1.73e-11 | 2.99e-01 | 0.0875 |
1952 | CELSR2 | P2T-E | Human | Esophagus | ESCC | 2.72e-28 | 4.23e-01 | 0.1177 |
1952 | CELSR2 | P4T-E | Human | Esophagus | ESCC | 8.86e-05 | 1.13e-01 | 0.1323 |
1952 | CELSR2 | P5T-E | Human | Esophagus | ESCC | 3.48e-08 | 1.39e-01 | 0.1327 |
1952 | CELSR2 | P8T-E | Human | Esophagus | ESCC | 7.94e-14 | 1.96e-01 | 0.0889 |
1952 | CELSR2 | P9T-E | Human | Esophagus | ESCC | 1.28e-03 | 3.85e-02 | 0.1131 |
1952 | CELSR2 | P10T-E | Human | Esophagus | ESCC | 1.77e-23 | 4.82e-01 | 0.116 |
1952 | CELSR2 | P11T-E | Human | Esophagus | ESCC | 2.02e-04 | 1.83e-01 | 0.1426 |
1952 | CELSR2 | P12T-E | Human | Esophagus | ESCC | 1.51e-30 | 5.87e-01 | 0.1122 |
1952 | CELSR2 | P15T-E | Human | Esophagus | ESCC | 1.75e-06 | 5.71e-02 | 0.1149 |
1952 | CELSR2 | P16T-E | Human | Esophagus | ESCC | 5.38e-20 | 1.41e-01 | 0.1153 |
1952 | CELSR2 | P17T-E | Human | Esophagus | ESCC | 1.17e-06 | 2.46e-01 | 0.1278 |
1952 | CELSR2 | P20T-E | Human | Esophagus | ESCC | 2.57e-06 | 1.01e-01 | 0.1124 |
1952 | CELSR2 | P21T-E | Human | Esophagus | ESCC | 1.14e-05 | 6.54e-02 | 0.1617 |
1952 | CELSR2 | P22T-E | Human | Esophagus | ESCC | 4.58e-12 | 9.43e-02 | 0.1236 |
1952 | CELSR2 | P23T-E | Human | Esophagus | ESCC | 1.23e-12 | 1.73e-01 | 0.108 |
1952 | CELSR2 | P24T-E | Human | Esophagus | ESCC | 1.48e-04 | 6.61e-02 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:00017387 | Esophagus | ESCC | morphogenesis of a polarized epithelium | 63/8552 | 94/18723 | 2.34e-05 | 2.00e-04 | 63 |
GO:00600714 | Esophagus | ESCC | Wnt signaling pathway, planar cell polarity pathway | 36/8552 | 52/18723 | 5.05e-04 | 2.79e-03 | 36 |
GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
GO:00901753 | Esophagus | ESCC | regulation of establishment of planar polarity | 37/8552 | 56/18723 | 1.65e-03 | 7.65e-03 | 37 |
GO:00017361 | Esophagus | ESCC | establishment of planar polarity | 45/8552 | 72/18723 | 2.97e-03 | 1.24e-02 | 45 |
GO:00071641 | Esophagus | ESCC | establishment of tissue polarity | 45/8552 | 72/18723 | 2.97e-03 | 1.24e-02 | 45 |
GO:00355671 | Esophagus | ESCC | non-canonical Wnt signaling pathway | 45/8552 | 72/18723 | 2.97e-03 | 1.24e-02 | 45 |
GO:20000274 | Esophagus | ESCC | regulation of animal organ morphogenesis | 71/8552 | 125/18723 | 7.97e-03 | 2.84e-02 | 71 |
GO:001635816 | Esophagus | ESCC | dendrite development | 130/8552 | 243/18723 | 8.33e-03 | 2.95e-02 | 130 |
GO:001605510 | Oral cavity | OSCC | Wnt signaling pathway | 227/7305 | 444/18723 | 1.10e-07 | 1.87e-06 | 227 |
GO:019873810 | Oral cavity | OSCC | cell-cell signaling by wnt | 227/7305 | 446/18723 | 1.75e-07 | 2.86e-06 | 227 |
GO:002240718 | Oral cavity | OSCC | regulation of cell-cell adhesion | 218/7305 | 448/18723 | 1.71e-05 | 1.68e-04 | 218 |
GO:005087819 | Oral cavity | OSCC | regulation of body fluid levels | 179/7305 | 379/18723 | 6.19e-04 | 3.50e-03 | 179 |
GO:0021591 | Oral cavity | OSCC | ventricular system development | 18/7305 | 29/18723 | 1.00e-02 | 3.49e-02 | 18 |
GO:001635810 | Oral cavity | OSCC | dendrite development | 113/7305 | 243/18723 | 1.00e-02 | 3.49e-02 | 113 |
GO:001605515 | Oral cavity | LP | Wnt signaling pathway | 140/4623 | 444/18723 | 5.80e-04 | 5.35e-03 | 140 |
GO:019873815 | Oral cavity | LP | cell-cell signaling by wnt | 140/4623 | 446/18723 | 7.12e-04 | 6.38e-03 | 140 |
GO:0016055110 | Thyroid | PTC | Wnt signaling pathway | 217/5968 | 444/18723 | 3.71e-14 | 2.30e-12 | 217 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CELSR2 | SNV | Missense_Mutation | rs760258795 | c.3772T>G | p.Ser1258Ala | p.S1258A | Q9HCU4 | protein_coding | deleterious(0) | benign(0.254) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CELSR2 | SNV | Missense_Mutation | rs202175893 | c.2237N>A | p.Arg746His | p.R746H | Q9HCU4 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
CELSR2 | SNV | Missense_Mutation | c.5817G>T | p.Glu1939Asp | p.E1939D | Q9HCU4 | protein_coding | tolerated(0.36) | benign(0.018) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CELSR2 | SNV | Missense_Mutation | rs780149025 | c.6757N>T | p.Arg2253Cys | p.R2253C | Q9HCU4 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CELSR2 | SNV | Missense_Mutation | rs771008996 | c.7414C>T | p.Arg2472Cys | p.R2472C | Q9HCU4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CELSR2 | SNV | Missense_Mutation | c.3685G>A | p.Asp1229Asn | p.D1229N | Q9HCU4 | protein_coding | deleterious(0) | possibly_damaging(0.712) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CELSR2 | SNV | Missense_Mutation | novel | c.2000N>C | p.Val667Ala | p.V667A | Q9HCU4 | protein_coding | deleterious(0) | possibly_damaging(0.489) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CELSR2 | SNV | Missense_Mutation | novel | c.2984N>C | p.Val995Ala | p.V995A | Q9HCU4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-4750-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD |
CELSR2 | SNV | Missense_Mutation | rs760959194 | c.6511G>A | p.Val2171Ile | p.V2171I | Q9HCU4 | protein_coding | tolerated(0.48) | benign(0.209) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
CELSR2 | SNV | Missense_Mutation | novel | c.2558C>A | p.Thr853Asn | p.T853N | Q9HCU4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-6680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1952 | CELSR2 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | hmg coa reductase inhibitors | 25350695 |
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