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Gene: CECR1 |
Gene summary for CECR1 |
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Gene information | Species | Human | Gene symbol | CECR1 | Gene ID | 51816 |
Gene name | adenosine deaminase 2 | |
Gene Alias | ADGF | |
Cytomap | 22q11.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NZK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51816 | CECR1 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 2.22e-03 | 5.24e-01 | 0.159 |
51816 | CECR1 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 6.49e-08 | 7.11e-01 | 0.1479 |
51816 | CECR1 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 2.22e-03 | 4.81e-01 | 0.1531 |
51816 | CECR1 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 4.40e-03 | 4.93e-01 | 0.159 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CECR1 | SNV | Missense_Mutation | rs140149634 | c.143N>T | p.Gly48Val | p.G48V | Q9NZK5 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-34-8455-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
CECR1 | SNV | Missense_Mutation | c.1072N>C | p.Gly358Arg | p.G358R | Q9NZK5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-43-6771-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CECR1 | SNV | Missense_Mutation | novel | c.1063N>A | p.Phe355Ile | p.F355I | Q9NZK5 | protein_coding | deleterious(0) | possibly_damaging(0.855) | TCGA-56-7582-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CECR1 | SNV | Missense_Mutation | novel | c.1204N>A | p.Asp402Asn | p.D402N | Q9NZK5 | protein_coding | tolerated(0.45) | benign(0.006) | TCGA-77-A5GH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CECR1 | SNV | Missense_Mutation | novel | c.451N>G | p.Pro151Ala | p.P151A | Q9NZK5 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CECR1 | insertion | Frame_Shift_Ins | novel | c.22_23insTG | p.Glu8ValfsTer24 | p.E8Vfs*24 | Q9NZK5 | protein_coding | TCGA-50-5946-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
CECR1 | SNV | Missense_Mutation | novel | c.403C>T | p.His135Tyr | p.H135Y | Q9NZK5 | protein_coding | tolerated(1) | benign(0) | TCGA-CN-4741-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
CECR1 | SNV | Missense_Mutation | novel | c.1418A>T | p.Lys473Ile | p.K473I | Q9NZK5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-7095-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CECR1 | SNV | Missense_Mutation | c.904N>A | p.Ala302Thr | p.A302T | Q9NZK5 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-CV-7416-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
CECR1 | SNV | Missense_Mutation | rs202134424 | c.139N>T | p.Gly47Trp | p.G47W | Q9NZK5 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-G9-6347-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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