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Gene: CD109 |
Gene summary for CD109 |
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Gene information | Species | Human | Gene symbol | CD109 | Gene ID | 135228 |
Gene name | CD109 molecule | |
Gene Alias | CPAMD7 | |
Cytomap | 6q13 | |
Gene Type | protein-coding | GO ID | GO:0000768 | UniProtAcc | Q6YHK3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
135228 | CD109 | CA_HPV_2 | Human | Cervix | CC | 8.22e-04 | 2.97e-01 | 0.0391 |
135228 | CD109 | CCI_1 | Human | Cervix | CC | 3.11e-12 | 1.47e+00 | 0.528 |
135228 | CD109 | Tumor | Human | Cervix | CC | 2.04e-02 | 2.21e-01 | 0.1241 |
135228 | CD109 | sample3 | Human | Cervix | CC | 2.49e-03 | 2.62e-01 | 0.1387 |
135228 | CD109 | H2 | Human | Cervix | HSIL_HPV | 4.09e-05 | -1.66e-01 | 0.0632 |
135228 | CD109 | T3 | Human | Cervix | CC | 4.56e-07 | 2.35e-01 | 0.1389 |
135228 | CD109 | LZE2T | Human | Esophagus | ESCC | 1.40e-02 | 3.36e-01 | 0.082 |
135228 | CD109 | LZE4T | Human | Esophagus | ESCC | 1.57e-16 | 3.99e-01 | 0.0811 |
135228 | CD109 | LZE24T | Human | Esophagus | ESCC | 3.88e-04 | -4.32e-02 | 0.0596 |
135228 | CD109 | LZE6T | Human | Esophagus | ESCC | 5.42e-03 | -3.94e-02 | 0.0845 |
135228 | CD109 | P2T-E | Human | Esophagus | ESCC | 7.05e-13 | 2.04e-01 | 0.1177 |
135228 | CD109 | P4T-E | Human | Esophagus | ESCC | 1.90e-17 | 6.25e-01 | 0.1323 |
135228 | CD109 | P5T-E | Human | Esophagus | ESCC | 4.03e-26 | 5.18e-01 | 0.1327 |
135228 | CD109 | P8T-E | Human | Esophagus | ESCC | 5.98e-06 | 1.85e-01 | 0.0889 |
135228 | CD109 | P9T-E | Human | Esophagus | ESCC | 2.47e-09 | 2.68e-01 | 0.1131 |
135228 | CD109 | P10T-E | Human | Esophagus | ESCC | 2.54e-16 | 3.07e-01 | 0.116 |
135228 | CD109 | P11T-E | Human | Esophagus | ESCC | 1.85e-06 | 6.39e-01 | 0.1426 |
135228 | CD109 | P12T-E | Human | Esophagus | ESCC | 2.55e-22 | 5.43e-01 | 0.1122 |
135228 | CD109 | P15T-E | Human | Esophagus | ESCC | 2.39e-17 | 6.11e-01 | 0.1149 |
135228 | CD109 | P16T-E | Human | Esophagus | ESCC | 1.46e-04 | 3.26e-04 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:00302164 | Cervix | CC | keratinocyte differentiation | 42/2311 | 139/18723 | 1.74e-08 | 1.28e-06 | 42 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:00099137 | Cervix | CC | epidermal cell differentiation | 53/2311 | 202/18723 | 5.48e-08 | 3.25e-06 | 53 |
GO:003009910 | Cervix | CC | myeloid cell differentiation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:00506787 | Cervix | CC | regulation of epithelial cell proliferation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:00513469 | Cervix | CC | negative regulation of hydrolase activity | 81/2311 | 379/18723 | 4.27e-07 | 1.67e-05 | 81 |
GO:19030349 | Cervix | CC | regulation of response to wounding | 44/2311 | 167/18723 | 6.33e-07 | 2.31e-05 | 44 |
GO:00104669 | Cervix | CC | negative regulation of peptidase activity | 60/2311 | 262/18723 | 1.27e-06 | 4.34e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:00456822 | Cervix | CC | regulation of epidermis development | 22/2311 | 65/18723 | 5.56e-06 | 1.38e-04 | 22 |
GO:001095110 | Cervix | CC | negative regulation of endopeptidase activity | 56/2311 | 252/18723 | 7.43e-06 | 1.74e-04 | 56 |
GO:00456042 | Cervix | CC | regulation of epidermal cell differentiation | 20/2311 | 58/18723 | 1.07e-05 | 2.33e-04 | 20 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD109 | SNV | Missense_Mutation | c.3866N>G | p.Glu1289Gly | p.E1289G | Q6YHK3 | protein_coding | deleterious(0) | benign(0.003) | TCGA-CA-6716-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | CR | |
CD109 | SNV | Missense_Mutation | novel | c.265N>G | p.Thr89Ala | p.T89A | Q6YHK3 | protein_coding | tolerated(0.07) | benign(0.021) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CD109 | SNV | Missense_Mutation | novel | c.434N>G | p.Glu145Gly | p.E145G | Q6YHK3 | protein_coding | tolerated(0.12) | possibly_damaging(0.636) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CD109 | SNV | Missense_Mutation | c.1162N>G | p.Asn388Asp | p.N388D | Q6YHK3 | protein_coding | tolerated(0.55) | benign(0.001) | TCGA-CM-5868-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
CD109 | SNV | Missense_Mutation | rs371377745 | c.704C>T | p.Thr235Ile | p.T235I | Q6YHK3 | protein_coding | deleterious(0.03) | benign(0.193) | TCGA-CM-6680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CD109 | SNV | Missense_Mutation | rs780970981 | c.794C>T | p.Thr265Met | p.T265M | Q6YHK3 | protein_coding | deleterious(0.01) | possibly_damaging(0.776) | TCGA-D5-5540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CD109 | SNV | Missense_Mutation | rs749134372 | c.2746C>T | p.Arg916Trp | p.R916W | Q6YHK3 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CD109 | SNV | Missense_Mutation | c.1917N>T | p.Trp639Cys | p.W639C | Q6YHK3 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CD109 | SNV | Missense_Mutation | rs373485830 | c.2060G>A | p.Arg687Gln | p.R687Q | Q6YHK3 | protein_coding | deleterious(0.03) | probably_damaging(0.987) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CD109 | SNV | Missense_Mutation | rs750803840 | c.3739N>A | p.Ala1247Thr | p.A1247T | Q6YHK3 | protein_coding | deleterious(0) | benign(0.052) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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