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Gene: CCZ1 |
Gene summary for CCZ1 |
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Gene information | Species | Human | Gene symbol | CCZ1 | Gene ID | 51622 |
Gene name | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated | |
Gene Alias | C7orf28A | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P86790 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51622 | CCZ1 | C04 | Human | Oral cavity | OSCC | 2.59e-04 | 4.37e-01 | 0.2633 |
51622 | CCZ1 | C21 | Human | Oral cavity | OSCC | 3.48e-46 | 1.28e+00 | 0.2678 |
51622 | CCZ1 | C30 | Human | Oral cavity | OSCC | 4.00e-49 | 2.36e+00 | 0.3055 |
51622 | CCZ1 | C38 | Human | Oral cavity | OSCC | 3.48e-08 | 1.03e+00 | 0.172 |
51622 | CCZ1 | C43 | Human | Oral cavity | OSCC | 1.06e-51 | 9.38e-01 | 0.1704 |
51622 | CCZ1 | C46 | Human | Oral cavity | OSCC | 3.97e-35 | 9.08e-01 | 0.1673 |
51622 | CCZ1 | C51 | Human | Oral cavity | OSCC | 2.17e-09 | 5.71e-01 | 0.2674 |
51622 | CCZ1 | C57 | Human | Oral cavity | OSCC | 1.73e-18 | 7.06e-01 | 0.1679 |
51622 | CCZ1 | C06 | Human | Oral cavity | OSCC | 3.10e-05 | 1.15e+00 | 0.2699 |
51622 | CCZ1 | C07 | Human | Oral cavity | OSCC | 2.44e-02 | 6.03e-01 | 0.2491 |
51622 | CCZ1 | C08 | Human | Oral cavity | OSCC | 1.26e-31 | 7.03e-01 | 0.1919 |
51622 | CCZ1 | C09 | Human | Oral cavity | OSCC | 2.19e-05 | 3.94e-01 | 0.1431 |
51622 | CCZ1 | LN38 | Human | Oral cavity | OSCC | 1.68e-02 | 8.59e-01 | 0.168 |
51622 | CCZ1 | LN46 | Human | Oral cavity | OSCC | 1.84e-16 | 9.40e-01 | 0.1666 |
51622 | CCZ1 | LP15 | Human | Oral cavity | LP | 4.58e-02 | 8.37e-01 | 0.2174 |
51622 | CCZ1 | LP17 | Human | Oral cavity | LP | 9.77e-04 | 8.34e-01 | 0.2349 |
51622 | CCZ1 | SYSMH1 | Human | Oral cavity | OSCC | 7.51e-17 | 3.73e-01 | 0.1127 |
51622 | CCZ1 | SYSMH2 | Human | Oral cavity | OSCC | 1.63e-19 | 6.02e-01 | 0.2326 |
51622 | CCZ1 | SYSMH3 | Human | Oral cavity | OSCC | 6.82e-09 | 3.57e-01 | 0.2442 |
51622 | CCZ1 | SYSMH5 | Human | Oral cavity | OSCC | 1.06e-03 | 2.02e-01 | 0.0647 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCZ1 | SNV | Missense_Mutation | novel | c.264N>T | p.Lys88Asn | p.K88N | P86791 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
CCZ1 | SNV | Missense_Mutation | novel | c.794N>G | p.Asp265Gly | p.D265G | P86791 | protein_coding | tolerated(0.36) | benign(0.028) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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