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Gene: CCDC34 |
Gene summary for CCDC34 |
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Gene information | Species | Human | Gene symbol | CCDC34 | Gene ID | 91057 |
Gene name | coiled-coil domain containing 34 | |
Gene Alias | L15 | |
Cytomap | 11p14.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96HJ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91057 | CCDC34 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.62e-14 | 4.89e-01 | -0.1954 |
91057 | CCDC34 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.32e-10 | 4.02e-01 | -0.1464 |
91057 | CCDC34 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.47e-06 | 2.69e-01 | -0.1001 |
91057 | CCDC34 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.83e-06 | 4.82e-01 | -0.059 |
91057 | CCDC34 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.20e-02 | 3.30e-01 | -0.0842 |
91057 | CCDC34 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.12e-04 | 2.79e-01 | 0.096 |
91057 | CCDC34 | HTA11_10623_2000001011 | Human | Colorectum | AD | 5.83e-04 | 4.14e-01 | -0.0177 |
91057 | CCDC34 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.15e-06 | 3.27e-01 | 0.0674 |
91057 | CCDC34 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.71e-08 | 3.32e-01 | 0.294 |
91057 | CCDC34 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 9.20e-03 | 8.54e-01 | 0.3487 |
91057 | CCDC34 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.27e-02 | 1.74e-01 | 0.281 |
91057 | CCDC34 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.03e-10 | 5.11e-01 | 0.3859 |
91057 | CCDC34 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.82e-05 | 2.68e-01 | 0.3005 |
91057 | CCDC34 | LZE2T | Human | Esophagus | ESCC | 5.69e-03 | 4.98e-01 | 0.082 |
91057 | CCDC34 | LZE4T | Human | Esophagus | ESCC | 1.38e-02 | 1.08e-01 | 0.0811 |
91057 | CCDC34 | LZE7T | Human | Esophagus | ESCC | 1.62e-07 | 4.12e-01 | 0.0667 |
91057 | CCDC34 | LZE8T | Human | Esophagus | ESCC | 1.18e-02 | 2.63e-01 | 0.067 |
91057 | CCDC34 | LZE22T | Human | Esophagus | ESCC | 7.58e-03 | 1.58e-01 | 0.068 |
91057 | CCDC34 | LZE24T | Human | Esophagus | ESCC | 4.88e-14 | 6.44e-01 | 0.0596 |
91057 | CCDC34 | LZE6T | Human | Esophagus | ESCC | 5.22e-05 | 2.90e-01 | 0.0845 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC34 | SNV | Missense_Mutation | novel | c.801G>C | p.Glu267Asp | p.E267D | Q96HJ3 | protein_coding | deleterious(0.03) | probably_damaging(0.913) | TCGA-DQ-5625-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CCDC34 | SNV | Missense_Mutation | c.361A>G | p.Thr121Ala | p.T121A | Q96HJ3 | protein_coding | tolerated(0.36) | benign(0) | TCGA-G9-6332-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | PD | |
CCDC34 | SNV | Missense_Mutation | c.1028N>A | p.Pro343His | p.P343H | Q96HJ3 | protein_coding | deleterious(0.02) | benign(0.012) | TCGA-CD-5799-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CCDC34 | SNV | Missense_Mutation | novel | c.82N>T | p.Pro28Ser | p.P28S | Q96HJ3 | protein_coding | tolerated_low_confidence(0.17) | benign(0.005) | TCGA-VQ-A8PC-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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