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Gene: CCDC171 |
Gene summary for CCDC171 |
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Gene information | Species | Human | Gene symbol | CCDC171 | Gene ID | 203238 |
Gene name | coiled-coil domain containing 171 | |
Gene Alias | C9orf93 | |
Cytomap | 9p22.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q6TFL3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
203238 | CCDC171 | AEH-subject3 | Human | Endometrium | AEH | 3.82e-02 | 2.23e-01 | -0.2576 |
203238 | CCDC171 | AEH-subject4 | Human | Endometrium | AEH | 2.35e-04 | 3.26e-01 | -0.2657 |
203238 | CCDC171 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.09e-04 | -7.02e-02 | -0.1917 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC171 | SNV | Missense_Mutation | novel | c.25N>C | p.Thr9Pro | p.T9P | Q6TFL3 | protein_coding | tolerated_low_confidence(0.08) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CCDC171 | SNV | Missense_Mutation | novel | c.1184N>A | p.Ser395Asn | p.S395N | Q6TFL3 | protein_coding | tolerated(0.26) | benign(0.124) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CCDC171 | SNV | Missense_Mutation | rs763283023 | c.1379N>A | p.Arg460His | p.R460H | Q6TFL3 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CCDC171 | SNV | Missense_Mutation | c.785G>A | p.Ser262Asn | p.S262N | Q6TFL3 | protein_coding | deleterious(0.01) | benign(0.295) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC171 | SNV | Missense_Mutation | c.2346G>T | p.Lys782Asn | p.K782N | Q6TFL3 | protein_coding | tolerated(0.79) | benign(0.015) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC171 | SNV | Missense_Mutation | rs746749844 | c.2185N>A | p.Ala729Thr | p.A729T | Q6TFL3 | protein_coding | tolerated(0.08) | possibly_damaging(0.634) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC171 | SNV | Missense_Mutation | novel | c.2903N>T | p.Ser968Ile | p.S968I | Q6TFL3 | protein_coding | deleterious(0.04) | benign(0.144) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC171 | SNV | Missense_Mutation | rs746234419 | c.3193N>A | p.Glu1065Lys | p.E1065K | Q6TFL3 | protein_coding | deleterious(0.04) | probably_damaging(0.99) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC171 | SNV | Missense_Mutation | rs142125441 | c.298N>T | p.Arg100Trp | p.R100W | Q6TFL3 | protein_coding | tolerated(0.18) | possibly_damaging(0.481) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC171 | SNV | Missense_Mutation | rs544298455 | c.2588N>T | p.Ala863Val | p.A863V | Q6TFL3 | protein_coding | tolerated(0.1) | benign(0.06) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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