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Gene: CASZ1 |
Gene summary for CASZ1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CASZ1 | Gene ID | 54897 |
Gene name | castor zinc finger 1 | |
Gene Alias | CAS11 | |
Cytomap | 1p36.22 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KRV8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54897 | CASZ1 | CCI_1 | Human | Cervix | CC | 4.93e-05 | 6.29e-01 | 0.528 |
54897 | CASZ1 | CCI_2 | Human | Cervix | CC | 5.09e-04 | 8.21e-01 | 0.5249 |
54897 | CASZ1 | CCI_3 | Human | Cervix | CC | 1.78e-09 | 7.41e-01 | 0.516 |
54897 | CASZ1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.75e-04 | -2.24e-01 | 0.0155 |
54897 | CASZ1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.54e-02 | 4.57e-01 | -0.1464 |
54897 | CASZ1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.23e-14 | -5.06e-01 | 0.294 |
54897 | CASZ1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.06e-03 | -2.68e-01 | 0.3005 |
54897 | CASZ1 | A002-C-010 | Human | Colorectum | FAP | 1.28e-07 | -2.84e-01 | 0.242 |
54897 | CASZ1 | A015-C-203 | Human | Colorectum | FAP | 4.67e-28 | -3.76e-01 | -0.1294 |
54897 | CASZ1 | A015-C-204 | Human | Colorectum | FAP | 1.68e-07 | -2.32e-01 | -0.0228 |
54897 | CASZ1 | A014-C-040 | Human | Colorectum | FAP | 1.20e-05 | -4.22e-01 | -0.1184 |
54897 | CASZ1 | A002-C-201 | Human | Colorectum | FAP | 4.11e-15 | -2.32e-01 | 0.0324 |
54897 | CASZ1 | A002-C-203 | Human | Colorectum | FAP | 1.33e-04 | -1.45e-01 | 0.2786 |
54897 | CASZ1 | A001-C-119 | Human | Colorectum | FAP | 1.99e-05 | -4.16e-02 | -0.1557 |
54897 | CASZ1 | A001-C-108 | Human | Colorectum | FAP | 1.46e-12 | -1.87e-01 | -0.0272 |
54897 | CASZ1 | A002-C-205 | Human | Colorectum | FAP | 9.27e-23 | -3.26e-01 | -0.1236 |
54897 | CASZ1 | A015-C-005 | Human | Colorectum | FAP | 1.53e-03 | -4.22e-02 | -0.0336 |
54897 | CASZ1 | A015-C-006 | Human | Colorectum | FAP | 2.51e-16 | -2.54e-01 | -0.0994 |
54897 | CASZ1 | A015-C-106 | Human | Colorectum | FAP | 2.72e-13 | -2.56e-01 | -0.0511 |
54897 | CASZ1 | A002-C-114 | Human | Colorectum | FAP | 2.92e-20 | -3.06e-01 | -0.1561 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CASZ1 | SNV | Missense_Mutation | c.3244N>G | p.Met1082Val | p.M1082V | Q86V15 | protein_coding | tolerated(0.3) | benign(0) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CASZ1 | SNV | Missense_Mutation | c.701N>T | p.Ala234Val | p.A234V | Q86V15 | protein_coding | tolerated_low_confidence(0.08) | benign(0.012) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CASZ1 | SNV | Missense_Mutation | c.587N>T | p.Thr196Met | p.T196M | Q86V15 | protein_coding | tolerated_low_confidence(0.32) | benign(0.014) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CASZ1 | SNV | Missense_Mutation | c.365N>G | p.Tyr122Cys | p.Y122C | Q86V15 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CASZ1 | SNV | Missense_Mutation | c.1268N>T | p.Asn423Ile | p.N423I | Q86V15 | protein_coding | deleterious_low_confidence(0) | benign(0.332) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CASZ1 | SNV | Missense_Mutation | c.2191N>A | p.Leu731Met | p.L731M | Q86V15 | protein_coding | tolerated(0.43) | benign(0.02) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CASZ1 | SNV | Missense_Mutation | rs775345608 | c.1762N>T | p.Arg588Cys | p.R588C | Q86V15 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-3890-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CASZ1 | SNV | Missense_Mutation | c.2985N>T | p.Lys995Asn | p.K995N | Q86V15 | protein_coding | deleterious(0.04) | possibly_damaging(0.883) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CASZ1 | SNV | Missense_Mutation | c.2170N>A | p.Asp724Asn | p.D724N | Q86V15 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
CASZ1 | SNV | Missense_Mutation | novel | c.992N>A | p.Ser331Asn | p.S331N | Q86V15 | protein_coding | tolerated_low_confidence(1) | benign(0.001) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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