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Gene: CARM1 |
Gene summary for CARM1 |
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Gene information | Species | Human | Gene symbol | CARM1 | Gene ID | 10498 |
Gene name | coactivator associated arginine methyltransferase 1 | |
Gene Alias | PRMT4 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q86X55 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10498 | CARM1 | LZE4T | Human | Esophagus | ESCC | 1.63e-02 | 6.60e-02 | 0.0811 |
10498 | CARM1 | LZE7T | Human | Esophagus | ESCC | 4.62e-09 | 3.55e-01 | 0.0667 |
10498 | CARM1 | LZE20T | Human | Esophagus | ESCC | 7.59e-05 | 1.11e-01 | 0.0662 |
10498 | CARM1 | LZE22T | Human | Esophagus | ESCC | 3.69e-02 | 1.47e-01 | 0.068 |
10498 | CARM1 | LZE24T | Human | Esophagus | ESCC | 6.71e-10 | 2.41e-01 | 0.0596 |
10498 | CARM1 | LZE21T | Human | Esophagus | ESCC | 2.86e-05 | 3.74e-01 | 0.0655 |
10498 | CARM1 | P1T-E | Human | Esophagus | ESCC | 1.17e-03 | 3.23e-01 | 0.0875 |
10498 | CARM1 | P2T-E | Human | Esophagus | ESCC | 3.63e-11 | 1.02e-01 | 0.1177 |
10498 | CARM1 | P4T-E | Human | Esophagus | ESCC | 4.22e-17 | 3.28e-01 | 0.1323 |
10498 | CARM1 | P5T-E | Human | Esophagus | ESCC | 1.67e-18 | 2.18e-01 | 0.1327 |
10498 | CARM1 | P8T-E | Human | Esophagus | ESCC | 5.31e-19 | 2.99e-01 | 0.0889 |
10498 | CARM1 | P9T-E | Human | Esophagus | ESCC | 1.06e-18 | 3.37e-01 | 0.1131 |
10498 | CARM1 | P10T-E | Human | Esophagus | ESCC | 1.29e-22 | 3.95e-01 | 0.116 |
10498 | CARM1 | P12T-E | Human | Esophagus | ESCC | 1.59e-17 | 3.76e-01 | 0.1122 |
10498 | CARM1 | P15T-E | Human | Esophagus | ESCC | 1.57e-08 | 1.66e-01 | 0.1149 |
10498 | CARM1 | P16T-E | Human | Esophagus | ESCC | 1.24e-10 | 6.52e-02 | 0.1153 |
10498 | CARM1 | P17T-E | Human | Esophagus | ESCC | 5.39e-06 | 1.78e-01 | 0.1278 |
10498 | CARM1 | P20T-E | Human | Esophagus | ESCC | 6.89e-06 | 7.70e-02 | 0.1124 |
10498 | CARM1 | P21T-E | Human | Esophagus | ESCC | 4.19e-16 | 2.21e-01 | 0.1617 |
10498 | CARM1 | P22T-E | Human | Esophagus | ESCC | 1.43e-18 | 2.12e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:0048545111 | Esophagus | ESCC | response to steroid hormone | 204/8552 | 339/18723 | 4.47e-08 | 8.11e-07 | 204 |
GO:000756820 | Esophagus | ESCC | aging | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:0071383110 | Esophagus | ESCC | cellular response to steroid hormone stimulus | 127/8552 | 204/18723 | 1.26e-06 | 1.55e-05 | 127 |
GO:003051819 | Esophagus | ESCC | intracellular steroid hormone receptor signaling pathway | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
GO:004340119 | Esophagus | ESCC | steroid hormone mediated signaling pathway | 87/8552 | 136/18723 | 1.25e-05 | 1.15e-04 | 87 |
GO:00165718 | Esophagus | ESCC | histone methylation | 89/8552 | 141/18723 | 2.17e-05 | 1.87e-04 | 89 |
GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
GO:00456007 | Esophagus | ESCC | positive regulation of fat cell differentiation | 46/8552 | 66/18723 | 6.72e-05 | 5.11e-04 | 46 |
GO:19052142 | Esophagus | ESCC | regulation of RNA binding | 12/8552 | 12/18723 | 8.21e-05 | 6.01e-04 | 12 |
GO:00331438 | Esophagus | ESCC | regulation of intracellular steroid hormone receptor signaling pathway | 50/8552 | 74/18723 | 1.16e-04 | 8.04e-04 | 50 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:000975516 | Esophagus | ESCC | hormone-mediated signaling pathway | 106/8552 | 190/18723 | 3.13e-03 | 1.30e-02 | 106 |
GO:003052014 | Esophagus | ESCC | intracellular estrogen receptor signaling pathway | 35/8552 | 54/18723 | 3.55e-03 | 1.45e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa015227 | Esophagus | ESCC | Endocrine resistance | 63/4205 | 98/8465 | 2.38e-03 | 6.58e-03 | 3.37e-03 | 63 |
hsa0152215 | Esophagus | ESCC | Endocrine resistance | 63/4205 | 98/8465 | 2.38e-03 | 6.58e-03 | 3.37e-03 | 63 |
hsa01522 | Liver | HCC | Endocrine resistance | 58/4020 | 98/8465 | 1.28e-02 | 3.19e-02 | 1.78e-02 | 58 |
hsa015221 | Liver | HCC | Endocrine resistance | 58/4020 | 98/8465 | 1.28e-02 | 3.19e-02 | 1.78e-02 | 58 |
hsa015226 | Oral cavity | OSCC | Endocrine resistance | 63/3704 | 98/8465 | 3.09e-05 | 1.31e-04 | 6.67e-05 | 63 |
hsa0152214 | Oral cavity | OSCC | Endocrine resistance | 63/3704 | 98/8465 | 3.09e-05 | 1.31e-04 | 6.67e-05 | 63 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CARM1 | SNV | Missense_Mutation | novel | c.1256G>A | p.Arg419Gln | p.R419Q | Q86X55 | protein_coding | deleterious(0.01) | possibly_damaging(0.765) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CARM1 | SNV | Missense_Mutation | novel | c.1787N>T | p.Pro596Leu | p.P596L | Q86X55 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-MX-A666-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicin | SD |
CARM1 | insertion | Frame_Shift_Ins | novel | c.227_228insTG | p.Phe80SerfsTer46 | p.F80Sfs*46 | Q86X55 | protein_coding | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | ||
CARM1 | insertion | Frame_Shift_Ins | novel | c.288_289insATTCT | p.Ser97IlefsTer30 | p.S97Ifs*30 | Q86X55 | protein_coding | TCGA-BR-8485-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 336446915 | ||
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | EOSIN | EOSIN | 18348515 | |
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 178103610 | ||
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 310264736 | ||
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 315661334 | ||
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 178103609 | ||
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 315661333 | BIIB021 |
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