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Gene: CAPRIN1 |
Gene summary for CAPRIN1 |
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Gene information | Species | Human | Gene symbol | CAPRIN1 | Gene ID | 4076 |
Gene name | cell cycle associated protein 1 | |
Gene Alias | GPIAP1 | |
Cytomap | 11p13 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q14444 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4076 | CAPRIN1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.85e-04 | 4.44e-01 | 0.294 |
4076 | CAPRIN1 | A015-C-203 | Human | Colorectum | FAP | 5.32e-29 | -4.15e-01 | -0.1294 |
4076 | CAPRIN1 | A015-C-204 | Human | Colorectum | FAP | 7.39e-05 | -3.09e-01 | -0.0228 |
4076 | CAPRIN1 | A014-C-040 | Human | Colorectum | FAP | 9.86e-05 | -5.67e-01 | -0.1184 |
4076 | CAPRIN1 | A002-C-201 | Human | Colorectum | FAP | 7.27e-09 | -2.87e-01 | 0.0324 |
4076 | CAPRIN1 | A002-C-203 | Human | Colorectum | FAP | 2.36e-04 | -1.41e-01 | 0.2786 |
4076 | CAPRIN1 | A001-C-119 | Human | Colorectum | FAP | 4.03e-04 | -2.64e-01 | -0.1557 |
4076 | CAPRIN1 | A001-C-108 | Human | Colorectum | FAP | 1.45e-11 | -2.39e-01 | -0.0272 |
4076 | CAPRIN1 | A002-C-205 | Human | Colorectum | FAP | 9.68e-15 | -3.12e-01 | -0.1236 |
4076 | CAPRIN1 | A001-C-104 | Human | Colorectum | FAP | 1.01e-02 | -1.10e-01 | 0.0184 |
4076 | CAPRIN1 | A015-C-006 | Human | Colorectum | FAP | 1.17e-08 | -3.55e-01 | -0.0994 |
4076 | CAPRIN1 | A015-C-106 | Human | Colorectum | FAP | 1.26e-09 | -2.52e-01 | -0.0511 |
4076 | CAPRIN1 | A002-C-114 | Human | Colorectum | FAP | 1.12e-11 | -3.20e-01 | -0.1561 |
4076 | CAPRIN1 | A015-C-104 | Human | Colorectum | FAP | 7.26e-27 | -3.13e-01 | -0.1899 |
4076 | CAPRIN1 | A001-C-014 | Human | Colorectum | FAP | 7.92e-15 | -3.12e-01 | 0.0135 |
4076 | CAPRIN1 | A002-C-016 | Human | Colorectum | FAP | 6.21e-19 | -2.80e-01 | 0.0521 |
4076 | CAPRIN1 | A015-C-002 | Human | Colorectum | FAP | 2.14e-07 | -2.60e-01 | -0.0763 |
4076 | CAPRIN1 | A001-C-203 | Human | Colorectum | FAP | 8.20e-07 | -1.77e-01 | -0.0481 |
4076 | CAPRIN1 | A002-C-116 | Human | Colorectum | FAP | 2.14e-26 | -3.24e-01 | -0.0452 |
4076 | CAPRIN1 | A014-C-008 | Human | Colorectum | FAP | 5.82e-08 | -3.75e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226042 | Colorectum | MSS | regulation of cell morphogenesis | 103/3467 | 309/18723 | 2.70e-10 | 2.56e-08 | 103 |
GO:00064172 | Colorectum | MSS | regulation of translation | 134/3467 | 468/18723 | 4.43e-08 | 2.38e-06 | 134 |
GO:01060272 | Colorectum | MSS | neuron projection organization | 34/3467 | 93/18723 | 3.04e-05 | 6.14e-04 | 34 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00107692 | Colorectum | MSS | regulation of cell morphogenesis involved in differentiation | 34/3467 | 96/18723 | 6.43e-05 | 1.12e-03 | 34 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
GO:00107702 | Colorectum | MSS | positive regulation of cell morphogenesis involved in differentiation | 29/3467 | 79/18723 | 1.04e-04 | 1.63e-03 | 29 |
GO:00107202 | Colorectum | MSS | positive regulation of cell development | 81/3467 | 298/18723 | 1.38e-04 | 2.06e-03 | 81 |
GO:00507671 | Colorectum | MSS | regulation of neurogenesis | 94/3467 | 364/18723 | 3.12e-04 | 4.06e-03 | 94 |
GO:00970612 | Colorectum | MSS | dendritic spine organization | 29/3467 | 84/18723 | 3.54e-04 | 4.50e-03 | 29 |
GO:00991732 | Colorectum | MSS | postsynapse organization | 48/3467 | 168/18723 | 9.32e-04 | 9.44e-03 | 48 |
GO:00163582 | Colorectum | MSS | dendrite development | 65/3467 | 243/18723 | 9.41e-04 | 9.50e-03 | 65 |
GO:0017148 | Colorectum | MSS | negative regulation of translation | 64/3467 | 245/18723 | 1.94e-03 | 1.67e-02 | 64 |
GO:0034249 | Colorectum | MSS | negative regulation of cellular amide metabolic process | 70/3467 | 273/18723 | 2.07e-03 | 1.76e-02 | 70 |
GO:00508082 | Colorectum | MSS | synapse organization | 101/3467 | 426/18723 | 3.96e-03 | 2.89e-02 | 101 |
GO:0050769 | Colorectum | MSS | positive regulation of neurogenesis | 57/3467 | 225/18723 | 6.60e-03 | 4.38e-02 | 57 |
GO:0051960 | Colorectum | MSS | regulation of nervous system development | 103/3467 | 443/18723 | 6.68e-03 | 4.38e-02 | 103 |
GO:00226044 | Colorectum | FAP | regulation of cell morphogenesis | 87/2622 | 309/18723 | 4.89e-11 | 1.87e-08 | 87 |
GO:00064174 | Colorectum | FAP | regulation of translation | 111/2622 | 468/18723 | 8.47e-09 | 1.13e-06 | 111 |
GO:00109753 | Colorectum | FAP | regulation of neuron projection development | 102/2622 | 445/18723 | 2.04e-07 | 1.24e-05 | 102 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPRIN1 | SNV | Missense_Mutation | novel | c.1919N>A | p.Arg640His | p.R640H | Q14444 | protein_coding | deleterious(0) | possibly_damaging(0.865) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CAPRIN1 | SNV | Missense_Mutation | c.448C>T | p.Leu150Phe | p.L150F | Q14444 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CAPRIN1 | SNV | Missense_Mutation | novel | c.1373N>A | p.Arg458Gln | p.R458Q | Q14444 | protein_coding | tolerated(0.26) | benign(0.04) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPRIN1 | SNV | Missense_Mutation | rs531594560 | c.716G>A | p.Arg239His | p.R239H | Q14444 | protein_coding | deleterious(0.02) | benign(0.073) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPRIN1 | SNV | Missense_Mutation | novel | c.1373G>A | p.Arg458Gln | p.R458Q | Q14444 | protein_coding | tolerated(0.26) | benign(0.04) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPRIN1 | SNV | Missense_Mutation | novel | c.1835G>A | p.Arg612His | p.R612H | Q14444 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPRIN1 | SNV | Missense_Mutation | rs763872104 | c.1918N>T | p.Arg640Cys | p.R640C | Q14444 | protein_coding | deleterious(0.01) | possibly_damaging(0.593) | TCGA-EY-A1GF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPRIN1 | SNV | Missense_Mutation | c.718N>A | p.Val240Ile | p.V240I | Q14444 | protein_coding | tolerated(0.38) | benign(0.01) | TCGA-DD-A4NI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CAPRIN1 | SNV | Missense_Mutation | c.791N>T | p.Ser264Leu | p.S264L | Q14444 | protein_coding | tolerated(0.26) | benign(0.036) | TCGA-49-4514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPRIN1 | SNV | Missense_Mutation | novel | c.1028N>T | p.Ser343Phe | p.S343F | Q14444 | protein_coding | tolerated(0.05) | benign(0.202) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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