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Gene: CAMSAP2 |
Gene summary for CAMSAP2 |
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Gene information | Species | Human | Gene symbol | CAMSAP2 | Gene ID | 23271 |
Gene name | calmodulin regulated spectrin associated protein family member 2 | |
Gene Alias | CAMSAP1L1 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B3KTI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23271 | CAMSAP2 | CCI_1 | Human | Cervix | CC | 5.64e-14 | 1.60e+00 | 0.528 |
23271 | CAMSAP2 | CCI_3 | Human | Cervix | CC | 1.39e-14 | 8.84e-01 | 0.516 |
23271 | CAMSAP2 | LZE4T | Human | Esophagus | ESCC | 7.57e-09 | 1.89e-01 | 0.0811 |
23271 | CAMSAP2 | LZE24T | Human | Esophagus | ESCC | 2.93e-04 | 4.35e-02 | 0.0596 |
23271 | CAMSAP2 | LZE21T | Human | Esophagus | ESCC | 8.90e-06 | 1.78e-01 | 0.0655 |
23271 | CAMSAP2 | P1T-E | Human | Esophagus | ESCC | 1.04e-02 | 1.73e-01 | 0.0875 |
23271 | CAMSAP2 | P2T-E | Human | Esophagus | ESCC | 2.12e-13 | 1.61e-01 | 0.1177 |
23271 | CAMSAP2 | P4T-E | Human | Esophagus | ESCC | 2.46e-08 | 1.78e-01 | 0.1323 |
23271 | CAMSAP2 | P5T-E | Human | Esophagus | ESCC | 2.11e-16 | 3.51e-01 | 0.1327 |
23271 | CAMSAP2 | P8T-E | Human | Esophagus | ESCC | 5.56e-12 | 2.50e-01 | 0.0889 |
23271 | CAMSAP2 | P9T-E | Human | Esophagus | ESCC | 3.11e-07 | 2.81e-01 | 0.1131 |
23271 | CAMSAP2 | P10T-E | Human | Esophagus | ESCC | 3.81e-24 | 1.97e-01 | 0.116 |
23271 | CAMSAP2 | P11T-E | Human | Esophagus | ESCC | 2.48e-06 | 3.29e-01 | 0.1426 |
23271 | CAMSAP2 | P12T-E | Human | Esophagus | ESCC | 4.41e-09 | 1.05e-01 | 0.1122 |
23271 | CAMSAP2 | P15T-E | Human | Esophagus | ESCC | 3.36e-06 | 1.96e-01 | 0.1149 |
23271 | CAMSAP2 | P16T-E | Human | Esophagus | ESCC | 1.62e-20 | 6.42e-02 | 0.1153 |
23271 | CAMSAP2 | P17T-E | Human | Esophagus | ESCC | 3.50e-02 | 2.92e-02 | 0.1278 |
23271 | CAMSAP2 | P19T-E | Human | Esophagus | ESCC | 2.39e-03 | 1.36e-01 | 0.1662 |
23271 | CAMSAP2 | P20T-E | Human | Esophagus | ESCC | 1.61e-10 | 4.11e-02 | 0.1124 |
23271 | CAMSAP2 | P21T-E | Human | Esophagus | ESCC | 4.60e-24 | 6.42e-01 | 0.1617 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:003227110 | Cervix | CC | regulation of protein polymerization | 57/2311 | 233/18723 | 2.37e-07 | 1.03e-05 | 57 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:19029048 | Cervix | CC | negative regulation of supramolecular fiber organization | 40/2311 | 167/18723 | 2.39e-05 | 4.17e-04 | 40 |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:00106399 | Cervix | CC | negative regulation of organelle organization | 68/2311 | 348/18723 | 7.40e-05 | 1.03e-03 | 68 |
GO:00514948 | Cervix | CC | negative regulation of cytoskeleton organization | 37/2311 | 163/18723 | 1.57e-04 | 1.88e-03 | 37 |
GO:00705074 | Cervix | CC | regulation of microtubule cytoskeleton organization | 32/2311 | 148/18723 | 1.02e-03 | 8.51e-03 | 32 |
GO:00311134 | Cervix | CC | regulation of microtubule polymerization | 15/2311 | 55/18723 | 2.14e-03 | 1.54e-02 | 15 |
GO:19033583 | Cervix | CC | regulation of Golgi organization | 7/2311 | 17/18723 | 2.72e-03 | 1.85e-02 | 7 |
GO:00070304 | Cervix | CC | Golgi organization | 32/2311 | 157/18723 | 2.78e-03 | 1.87e-02 | 32 |
GO:00467853 | Cervix | CC | microtubule polymerization | 19/2311 | 83/18723 | 5.25e-03 | 3.08e-02 | 19 |
GO:00329847 | Cervix | CC | protein-containing complex disassembly | 41/2311 | 224/18723 | 6.13e-03 | 3.48e-02 | 41 |
GO:00507733 | Cervix | CC | regulation of dendrite development | 22/2311 | 103/18723 | 6.75e-03 | 3.71e-02 | 22 |
GO:00311224 | Cervix | CC | cytoplasmic microtubule organization | 14/2311 | 56/18723 | 6.93e-03 | 3.74e-02 | 14 |
GO:0031111 | Cervix | CC | negative regulation of microtubule polymerization or depolymerization | 11/2311 | 40/18723 | 7.54e-03 | 4.02e-02 | 11 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMSAP2 | SNV | Missense_Mutation | rs144674686 | c.2894N>A | p.Arg965His | p.R965H | Q08AD1 | protein_coding | tolerated(0.21) | benign(0.056) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAMSAP2 | SNV | Missense_Mutation | rs199622691 | c.3715N>T | p.Arg1239Trp | p.R1239W | Q08AD1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAMSAP2 | SNV | Missense_Mutation | rs775199276 | c.2317N>T | p.Arg773Cys | p.R773C | Q08AD1 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CAMSAP2 | SNV | Missense_Mutation | c.61C>T | p.Pro21Ser | p.P21S | Q08AD1 | protein_coding | tolerated(0.83) | benign(0.003) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
CAMSAP2 | SNV | Missense_Mutation | c.3319N>A | p.Pro1107Thr | p.P1107T | Q08AD1 | protein_coding | tolerated(0.43) | benign(0.057) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAMSAP2 | SNV | Missense_Mutation | rs140682641 | c.3964C>T | p.Arg1322Cys | p.R1322C | Q08AD1 | protein_coding | tolerated(0.07) | probably_damaging(0.972) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAMSAP2 | SNV | Missense_Mutation | c.1931N>T | p.Thr644Ile | p.T644I | Q08AD1 | protein_coding | deleterious(0.01) | possibly_damaging(0.614) | TCGA-CI-6624-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CAMSAP2 | SNV | Missense_Mutation | novel | c.1521N>A | p.Ser507Arg | p.S507R | Q08AD1 | protein_coding | tolerated(0.42) | benign(0) | TCGA-DC-5869-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CAMSAP2 | SNV | Missense_Mutation | rs748956832 | c.1991N>A | p.Arg664Gln | p.R664Q | Q08AD1 | protein_coding | tolerated(0.1) | benign(0.006) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CAMSAP2 | deletion | Frame_Shift_Del | c.4303delN | p.Met1437Ter | p.M1437* | Q08AD1 | protein_coding | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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