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Gene: CADM4 |
Gene summary for CADM4 |
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Gene information | Species | Human | Gene symbol | CADM4 | Gene ID | 199731 |
Gene name | cell adhesion molecule 4 | |
Gene Alias | IGSF4C | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q8NFZ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
199731 | CADM4 | LZE5T | Human | Esophagus | ESCC | 2.14e-02 | 2.43e-01 | 0.0514 |
199731 | CADM4 | LZE24T | Human | Esophagus | ESCC | 5.20e-06 | 1.75e-01 | 0.0596 |
199731 | CADM4 | P1T-E | Human | Esophagus | ESCC | 5.49e-06 | 3.28e-01 | 0.0875 |
199731 | CADM4 | P2T-E | Human | Esophagus | ESCC | 2.06e-22 | 4.51e-01 | 0.1177 |
199731 | CADM4 | P4T-E | Human | Esophagus | ESCC | 6.24e-16 | 4.38e-01 | 0.1323 |
199731 | CADM4 | P8T-E | Human | Esophagus | ESCC | 6.77e-21 | 2.97e-01 | 0.0889 |
199731 | CADM4 | P9T-E | Human | Esophagus | ESCC | 2.63e-02 | 9.81e-02 | 0.1131 |
199731 | CADM4 | P10T-E | Human | Esophagus | ESCC | 1.55e-29 | 5.71e-01 | 0.116 |
199731 | CADM4 | P11T-E | Human | Esophagus | ESCC | 5.97e-08 | 3.12e-01 | 0.1426 |
199731 | CADM4 | P12T-E | Human | Esophagus | ESCC | 6.99e-28 | 5.68e-01 | 0.1122 |
199731 | CADM4 | P15T-E | Human | Esophagus | ESCC | 1.09e-09 | 2.04e-01 | 0.1149 |
199731 | CADM4 | P16T-E | Human | Esophagus | ESCC | 3.26e-15 | 3.17e-01 | 0.1153 |
199731 | CADM4 | P17T-E | Human | Esophagus | ESCC | 8.19e-03 | 2.62e-01 | 0.1278 |
199731 | CADM4 | P21T-E | Human | Esophagus | ESCC | 1.31e-06 | 1.26e-01 | 0.1617 |
199731 | CADM4 | P22T-E | Human | Esophagus | ESCC | 1.44e-05 | 1.32e-01 | 0.1236 |
199731 | CADM4 | P23T-E | Human | Esophagus | ESCC | 1.10e-12 | 2.86e-01 | 0.108 |
199731 | CADM4 | P24T-E | Human | Esophagus | ESCC | 2.57e-05 | 2.02e-01 | 0.1287 |
199731 | CADM4 | P26T-E | Human | Esophagus | ESCC | 1.38e-15 | 3.34e-01 | 0.1276 |
199731 | CADM4 | P27T-E | Human | Esophagus | ESCC | 2.67e-15 | 2.93e-01 | 0.1055 |
199731 | CADM4 | P28T-E | Human | Esophagus | ESCC | 4.34e-13 | 1.86e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
GO:0001933111 | Esophagus | ESCC | negative regulation of protein phosphorylation | 213/8552 | 342/18723 | 3.54e-10 | 9.76e-09 | 213 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:00166019 | Esophagus | ESCC | Rac protein signal transduction | 33/8552 | 42/18723 | 1.35e-05 | 1.23e-04 | 33 |
GO:00507322 | Esophagus | ESCC | negative regulation of peptidyl-tyrosine phosphorylation | 42/8552 | 59/18723 | 6.35e-05 | 4.84e-04 | 42 |
GO:0035020 | Esophagus | ESCC | regulation of Rac protein signal transduction | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:00507303 | Esophagus | ESCC | regulation of peptidyl-tyrosine phosphorylation | 144/8552 | 264/18723 | 2.22e-03 | 9.78e-03 | 144 |
GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
GO:190303420 | Esophagus | ESCC | regulation of response to wounding | 93/8552 | 167/18723 | 5.77e-03 | 2.14e-02 | 93 |
GO:001810710 | Esophagus | ESCC | peptidyl-threonine phosphorylation | 66/8552 | 116/18723 | 9.76e-03 | 3.37e-02 | 66 |
GO:001821010 | Esophagus | ESCC | peptidyl-threonine modification | 70/8552 | 125/18723 | 1.29e-02 | 4.25e-02 | 70 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:0010563113 | Thyroid | PTC | negative regulation of phosphorus metabolic process | 219/5968 | 442/18723 | 4.47e-15 | 3.07e-13 | 219 |
GO:0045936113 | Thyroid | PTC | negative regulation of phosphate metabolic process | 218/5968 | 441/18723 | 7.08e-15 | 4.75e-13 | 218 |
GO:0001933113 | Thyroid | PTC | negative regulation of protein phosphorylation | 173/5968 | 342/18723 | 3.46e-13 | 1.75e-11 | 173 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CADM4 | SNV | Missense_Mutation | c.262C>T | p.Arg88Trp | p.R88W | Q8NFZ8 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CADM4 | SNV | Missense_Mutation | rs753225057 | c.133N>T | p.Arg45Cys | p.R45C | Q8NFZ8 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CADM4 | SNV | Missense_Mutation | novel | c.479N>A | p.Arg160Gln | p.R160Q | Q8NFZ8 | protein_coding | deleterious(0.01) | possibly_damaging(0.673) | TCGA-VQ-A94O-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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