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Gene: C3orf67 |
Gene summary for C3ORF67 |
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Gene information | Species | Human | Gene symbol | C3orf67 | Gene ID | 200844 |
Gene name | CFAP20 domain containing | |
Gene Alias | C3orf67 | |
Cytomap | 3p14.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q6ZVT6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200844 | C3orf67 | LZE4T | Human | Esophagus | ESCC | 3.18e-05 | 1.69e-01 | 0.0811 |
200844 | C3orf67 | LZE24T | Human | Esophagus | ESCC | 1.89e-10 | 2.97e-01 | 0.0596 |
200844 | C3orf67 | P2T-E | Human | Esophagus | ESCC | 1.28e-06 | 1.94e-01 | 0.1177 |
200844 | C3orf67 | P4T-E | Human | Esophagus | ESCC | 7.21e-12 | 2.53e-01 | 0.1323 |
200844 | C3orf67 | P5T-E | Human | Esophagus | ESCC | 4.34e-07 | 1.36e-01 | 0.1327 |
200844 | C3orf67 | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 1.75e-01 | 0.1131 |
200844 | C3orf67 | P12T-E | Human | Esophagus | ESCC | 5.25e-16 | 2.79e-01 | 0.1122 |
200844 | C3orf67 | P15T-E | Human | Esophagus | ESCC | 5.26e-03 | 9.13e-02 | 0.1149 |
200844 | C3orf67 | P20T-E | Human | Esophagus | ESCC | 9.54e-15 | 3.11e-01 | 0.1124 |
200844 | C3orf67 | P21T-E | Human | Esophagus | ESCC | 1.23e-11 | 2.97e-01 | 0.1617 |
200844 | C3orf67 | P22T-E | Human | Esophagus | ESCC | 1.06e-07 | 1.68e-01 | 0.1236 |
200844 | C3orf67 | P23T-E | Human | Esophagus | ESCC | 4.97e-06 | 1.64e-01 | 0.108 |
200844 | C3orf67 | P26T-E | Human | Esophagus | ESCC | 3.55e-03 | 1.38e-01 | 0.1276 |
200844 | C3orf67 | P27T-E | Human | Esophagus | ESCC | 2.61e-05 | 1.64e-01 | 0.1055 |
200844 | C3orf67 | P28T-E | Human | Esophagus | ESCC | 8.53e-04 | 1.14e-01 | 0.1149 |
200844 | C3orf67 | P30T-E | Human | Esophagus | ESCC | 1.72e-15 | 4.36e-01 | 0.137 |
200844 | C3orf67 | P31T-E | Human | Esophagus | ESCC | 1.25e-10 | 2.33e-01 | 0.1251 |
200844 | C3orf67 | P32T-E | Human | Esophagus | ESCC | 1.10e-14 | 3.48e-01 | 0.1666 |
200844 | C3orf67 | P36T-E | Human | Esophagus | ESCC | 2.98e-06 | 1.84e-01 | 0.1187 |
200844 | C3orf67 | P37T-E | Human | Esophagus | ESCC | 1.93e-09 | 1.95e-01 | 0.1371 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C3orf67 | SNV | Missense_Mutation | novel | c.281C>T | p.Thr94Ile | p.T94I | Q6ZVT6 | protein_coding | deleterious(0.01) | possibly_damaging(0.839) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
C3orf67 | SNV | Missense_Mutation | c.1486N>T | p.Asp496Tyr | p.D496Y | Q6ZVT6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C3orf67 | SNV | Missense_Mutation | novel | c.1331N>G | p.His444Arg | p.H444R | Q6ZVT6 | protein_coding | deleterious(0.04) | possibly_damaging(0.626) | TCGA-CR-7398-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C3orf67 | SNV | Missense_Mutation | rs139831294 | c.1609G>A | p.Glu537Lys | p.E537K | Q6ZVT6 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
C3orf67 | SNV | Missense_Mutation | c.1308N>C | p.Glu436Asp | p.E436D | Q6ZVT6 | protein_coding | tolerated(0.16) | benign(0.026) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C3orf67 | SNV | Missense_Mutation | c.244N>G | p.Thr82Ala | p.T82A | Q6ZVT6 | protein_coding | tolerated(0.06) | benign(0.12) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
C3orf67 | SNV | Missense_Mutation | c.280N>G | p.Thr94Ala | p.T94A | Q6ZVT6 | protein_coding | tolerated(0.08) | benign(0.359) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
C3orf67 | SNV | Missense_Mutation | rs766560118 | c.1439N>A | p.Arg480His | p.R480H | Q6ZVT6 | protein_coding | tolerated(1) | benign(0.003) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
C3orf67 | SNV | Missense_Mutation | novel | c.629T>C | p.Val210Ala | p.V210A | Q6ZVT6 | protein_coding | tolerated(0.22) | benign(0.009) | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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