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Gene: C1RL |
Gene summary for C1RL |
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Gene information | Species | Human | Gene symbol | C1RL | Gene ID | 51279 |
Gene name | complement C1r subcomponent like | |
Gene Alias | C1RL1 | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0002250 | UniProtAcc | Q9NZP8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51279 | C1RL | LZE4T | Human | Esophagus | ESCC | 8.92e-03 | 1.43e-01 | 0.0811 |
51279 | C1RL | LZE8T | Human | Esophagus | ESCC | 1.72e-09 | 3.64e-01 | 0.067 |
51279 | C1RL | LZE20T | Human | Esophagus | ESCC | 3.70e-04 | 8.53e-02 | 0.0662 |
51279 | C1RL | LZE22T | Human | Esophagus | ESCC | 1.12e-02 | 1.72e-01 | 0.068 |
51279 | C1RL | LZE24T | Human | Esophagus | ESCC | 1.02e-06 | 1.80e-01 | 0.0596 |
51279 | C1RL | LZE6T | Human | Esophagus | ESCC | 4.19e-02 | 2.02e-01 | 0.0845 |
51279 | C1RL | P1T-E | Human | Esophagus | ESCC | 1.49e-03 | 3.03e-01 | 0.0875 |
51279 | C1RL | P2T-E | Human | Esophagus | ESCC | 2.07e-45 | 7.30e-01 | 0.1177 |
51279 | C1RL | P4T-E | Human | Esophagus | ESCC | 5.15e-08 | 2.90e-01 | 0.1323 |
51279 | C1RL | P5T-E | Human | Esophagus | ESCC | 1.40e-10 | 1.09e-01 | 0.1327 |
51279 | C1RL | P8T-E | Human | Esophagus | ESCC | 1.46e-23 | 4.43e-01 | 0.0889 |
51279 | C1RL | P9T-E | Human | Esophagus | ESCC | 1.25e-14 | 3.73e-01 | 0.1131 |
51279 | C1RL | P10T-E | Human | Esophagus | ESCC | 1.85e-18 | 1.31e-01 | 0.116 |
51279 | C1RL | P11T-E | Human | Esophagus | ESCC | 5.44e-06 | 2.29e-01 | 0.1426 |
51279 | C1RL | P12T-E | Human | Esophagus | ESCC | 9.63e-28 | 3.98e-01 | 0.1122 |
51279 | C1RL | P15T-E | Human | Esophagus | ESCC | 4.54e-12 | 2.92e-01 | 0.1149 |
51279 | C1RL | P16T-E | Human | Esophagus | ESCC | 6.87e-75 | 1.36e+00 | 0.1153 |
51279 | C1RL | P17T-E | Human | Esophagus | ESCC | 1.78e-03 | 3.08e-01 | 0.1278 |
51279 | C1RL | P19T-E | Human | Esophagus | ESCC | 8.72e-05 | 3.84e-01 | 0.1662 |
51279 | C1RL | P20T-E | Human | Esophagus | ESCC | 2.17e-10 | 3.48e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:0031638 | Liver | NAFLD | zymogen activation | 16/1882 | 60/18723 | 2.08e-04 | 3.60e-03 | 16 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:00316381 | Liver | Cirrhotic | zymogen activation | 31/4634 | 60/18723 | 6.48e-06 | 1.02e-04 | 31 |
GO:00164853 | Liver | Cirrhotic | protein processing | 85/4634 | 225/18723 | 9.01e-06 | 1.32e-04 | 85 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:001648511 | Liver | HCC | protein processing | 121/7958 | 225/18723 | 4.01e-04 | 2.71e-03 | 121 |
GO:00316382 | Liver | HCC | zymogen activation | 38/7958 | 60/18723 | 9.06e-04 | 5.33e-03 | 38 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:00164856 | Oral cavity | OSCC | protein processing | 121/7305 | 225/18723 | 4.56e-06 | 5.23e-05 | 121 |
GO:005160432 | Oral cavity | NEOLP | protein maturation | 50/2005 | 294/18723 | 6.46e-04 | 5.47e-03 | 50 |
GO:001648521 | Oral cavity | NEOLP | protein processing | 39/2005 | 225/18723 | 1.68e-03 | 1.17e-02 | 39 |
GO:000225313 | Oral cavity | NEOLP | activation of immune response | 55/2005 | 375/18723 | 9.87e-03 | 4.62e-02 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1RL | deletion | Frame_Shift_Del | c.1051delN | p.Leu351TrpfsTer35 | p.L351Wfs*35 | Q9NZP8 | protein_coding | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
C1RL | deletion | Frame_Shift_Del | novel | c.1032_1036delGCTGC | p.Leu345AlafsTer17 | p.L345Afs*17 | Q9NZP8 | protein_coding | TCGA-D7-A6F0-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C1RL | deletion | Frame_Shift_Del | novel | c.1270delN | p.Asp424MetfsTer37 | p.D424Mfs*37 | Q9NZP8 | protein_coding | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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