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Gene: C14orf37 |
Gene summary for C14ORF37 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C14orf37 | Gene ID | 145407 |
Gene name | armadillo like helical domain containing 4 | |
Gene Alias | C14orf37 | |
Cytomap | 14q23.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B2RUU6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
145407 | C14orf37 | P1T-E | Human | Esophagus | ESCC | 2.75e-04 | 2.67e-01 | 0.0875 |
145407 | C14orf37 | P2T-E | Human | Esophagus | ESCC | 1.75e-23 | 4.17e-01 | 0.1177 |
145407 | C14orf37 | P4T-E | Human | Esophagus | ESCC | 1.72e-08 | 2.50e-01 | 0.1323 |
145407 | C14orf37 | P5T-E | Human | Esophagus | ESCC | 2.65e-04 | 1.74e-01 | 0.1327 |
145407 | C14orf37 | P8T-E | Human | Esophagus | ESCC | 4.70e-10 | 1.96e-01 | 0.0889 |
145407 | C14orf37 | P10T-E | Human | Esophagus | ESCC | 8.26e-17 | 3.46e-01 | 0.116 |
145407 | C14orf37 | P11T-E | Human | Esophagus | ESCC | 3.00e-05 | 2.69e-01 | 0.1426 |
145407 | C14orf37 | P12T-E | Human | Esophagus | ESCC | 1.42e-08 | 9.73e-02 | 0.1122 |
145407 | C14orf37 | P15T-E | Human | Esophagus | ESCC | 4.96e-07 | 2.25e-01 | 0.1149 |
145407 | C14orf37 | P16T-E | Human | Esophagus | ESCC | 1.73e-14 | 2.22e-01 | 0.1153 |
145407 | C14orf37 | P20T-E | Human | Esophagus | ESCC | 1.94e-07 | 2.22e-01 | 0.1124 |
145407 | C14orf37 | P22T-E | Human | Esophagus | ESCC | 1.65e-13 | 2.34e-01 | 0.1236 |
145407 | C14orf37 | P23T-E | Human | Esophagus | ESCC | 3.58e-02 | 1.30e-01 | 0.108 |
145407 | C14orf37 | P26T-E | Human | Esophagus | ESCC | 8.29e-21 | 4.39e-01 | 0.1276 |
145407 | C14orf37 | P27T-E | Human | Esophagus | ESCC | 9.18e-08 | 2.37e-01 | 0.1055 |
145407 | C14orf37 | P30T-E | Human | Esophagus | ESCC | 1.72e-11 | 4.39e-01 | 0.137 |
145407 | C14orf37 | P32T-E | Human | Esophagus | ESCC | 1.64e-04 | 7.24e-02 | 0.1666 |
145407 | C14orf37 | P37T-E | Human | Esophagus | ESCC | 9.18e-03 | 9.73e-02 | 0.1371 |
145407 | C14orf37 | P39T-E | Human | Esophagus | ESCC | 2.96e-02 | 9.23e-02 | 0.0894 |
145407 | C14orf37 | P47T-E | Human | Esophagus | ESCC | 1.81e-02 | 1.28e-01 | 0.1067 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C14orf37 | SNV | Missense_Mutation | c.1285G>A | p.Asp429Asn | p.D429N | Q86TY3 | protein_coding | tolerated(0.49) | benign(0.007) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C14orf37 | SNV | Missense_Mutation | novel | c.1893N>T | p.Glu631Asp | p.E631D | Q86TY3 | protein_coding | deleterious(0.05) | probably_damaging(0.996) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C14orf37 | SNV | Missense_Mutation | c.1169N>A | p.Pro390His | p.P390H | Q86TY3 | protein_coding | deleterious(0.01) | possibly_damaging(0.794) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C14orf37 | SNV | Missense_Mutation | c.1547N>T | p.Arg516Ile | p.R516I | Q86TY3 | protein_coding | deleterious(0.03) | possibly_damaging(0.576) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
C14orf37 | SNV | Missense_Mutation | rs765276741 | c.1180N>A | p.Asp394Asn | p.D394N | Q86TY3 | protein_coding | tolerated(0.27) | benign(0.015) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C14orf37 | SNV | Missense_Mutation | c.1547N>T | p.Arg516Ile | p.R516I | Q86TY3 | protein_coding | deleterious(0.03) | possibly_damaging(0.576) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C14orf37 | SNV | Missense_Mutation | novel | c.987N>T | p.Lys329Asn | p.K329N | Q86TY3 | protein_coding | tolerated(0.17) | benign(0.007) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
C14orf37 | SNV | Missense_Mutation | c.1589N>A | p.Pro530His | p.P530H | Q86TY3 | protein_coding | tolerated(0.08) | probably_damaging(0.986) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
C14orf37 | SNV | Missense_Mutation | c.1468N>T | p.Asp490Tyr | p.D490Y | Q86TY3 | protein_coding | deleterious(0.02) | possibly_damaging(0.655) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
C14orf37 | SNV | Missense_Mutation | novel | c.532N>A | p.Glu178Lys | p.E178K | Q86TY3 | protein_coding | deleterious(0.03) | possibly_damaging(0.856) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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