GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001416 | Thyroid | ATC | mitotic nuclear division | 171/6293 | 287/18723 | 1.13e-19 | 1.66e-17 | 171 |
GO:003304423 | Thyroid | ATC | regulation of chromosome organization | 119/6293 | 187/18723 | 3.55e-17 | 3.40e-15 | 119 |
GO:004477219 | Thyroid | ATC | mitotic cell cycle phase transition | 223/6293 | 424/18723 | 3.46e-16 | 2.88e-14 | 223 |
GO:000007013 | Thyroid | ATC | mitotic sister chromatid segregation | 108/6293 | 168/18723 | 3.53e-16 | 2.90e-14 | 108 |
GO:000734622 | Thyroid | ATC | regulation of mitotic cell cycle | 236/6293 | 457/18723 | 7.58e-16 | 5.92e-14 | 236 |
GO:000081913 | Thyroid | ATC | sister chromatid segregation | 122/6293 | 202/18723 | 4.71e-15 | 3.17e-13 | 122 |
GO:000705913 | Thyroid | ATC | chromosome segregation | 183/6293 | 346/18723 | 8.03e-14 | 4.23e-12 | 183 |
GO:001063926 | Thyroid | ATC | negative regulation of organelle organization | 179/6293 | 348/18723 | 3.74e-12 | 1.50e-10 | 179 |
GO:190199015 | Thyroid | ATC | regulation of mitotic cell cycle phase transition | 156/6293 | 299/18723 | 2.19e-11 | 7.80e-10 | 156 |
GO:005198311 | Thyroid | ATC | regulation of chromosome segregation | 60/6293 | 91/18723 | 2.83e-10 | 8.10e-09 | 60 |
GO:009881312 | Thyroid | ATC | nuclear chromosome segregation | 145/6293 | 281/18723 | 3.06e-10 | 8.61e-09 | 145 |
GO:003007111 | Thyroid | ATC | regulation of mitotic metaphase/anaphase transition | 44/6293 | 60/18723 | 3.54e-10 | 9.86e-09 | 44 |
GO:000709111 | Thyroid | ATC | metaphase/anaphase transition of mitotic cell cycle | 45/6293 | 62/18723 | 3.93e-10 | 1.08e-08 | 45 |
GO:004828512 | Thyroid | ATC | organelle fission | 229/6293 | 488/18723 | 4.79e-10 | 1.29e-08 | 229 |
GO:190581811 | Thyroid | ATC | regulation of chromosome separation | 50/6293 | 72/18723 | 5.42e-10 | 1.45e-08 | 50 |
GO:001096511 | Thyroid | ATC | regulation of mitotic sister chromatid separation | 46/6293 | 65/18723 | 9.91e-10 | 2.55e-08 | 46 |
GO:005130611 | Thyroid | ATC | mitotic sister chromatid separation | 47/6293 | 67/18723 | 1.05e-09 | 2.67e-08 | 47 |
GO:000028011 | Thyroid | ATC | nuclear division | 207/6293 | 439/18723 | 1.98e-09 | 4.80e-08 | 207 |
GO:190198715 | Thyroid | ATC | regulation of cell cycle phase transition | 187/6293 | 390/18723 | 2.36e-09 | 5.61e-08 | 187 |
GO:000708811 | Thyroid | ATC | regulation of mitotic nuclear division | 67/6293 | 110/18723 | 3.98e-09 | 9.08e-08 | 67 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BUB1B | SNV | Missense_Mutation | novel | c.1501N>A | p.Val501Ile | p.V501I | O60566 | protein_coding | tolerated(0.19) | benign(0.01) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BUB1B | SNV | Missense_Mutation | novel | c.1664G>A | p.Arg555Gln | p.R555Q | O60566 | protein_coding | deleterious(0.05) | probably_damaging(0.977) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BUB1B | SNV | Missense_Mutation | novel | c.2438A>T | p.Glu813Val | p.E813V | O60566 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BUB1B | SNV | Missense_Mutation | novel | c.812G>T | p.Arg271Ile | p.R271I | O60566 | protein_coding | tolerated(0.1) | possibly_damaging(0.548) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
BUB1B | SNV | Missense_Mutation | novel | c.2948A>C | p.Asn983Thr | p.N983T | O60566 | protein_coding | tolerated(0.14) | benign(0.074) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
BUB1B | SNV | Missense_Mutation | novel | c.576N>T | p.Gln192His | p.Q192H | O60566 | protein_coding | tolerated(1) | benign(0) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BUB1B | SNV | Missense_Mutation | novel | c.481N>A | p.Glu161Lys | p.E161K | O60566 | protein_coding | tolerated(0.09) | possibly_damaging(0.902) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
BUB1B | SNV | Missense_Mutation | novel | c.904N>G | p.Arg302Gly | p.R302G | O60566 | protein_coding | deleterious(0) | possibly_damaging(0.791) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
BUB1B | SNV | Missense_Mutation | novel | c.1783N>T | p.Gly595Cys | p.G595C | O60566 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
BUB1B | deletion | Frame_Shift_Del | novel | c.22delN | p.Gly9ValfsTer3 | p.G9Vfs*3 | O60566 | protein_coding | | | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |