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Gene: BTN2A2 |
Gene summary for BTN2A2 |
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Gene information | Species | Human | Gene symbol | BTN2A2 | Gene ID | 10385 |
Gene name | butyrophilin subfamily 2 member A2 | |
Gene Alias | BT2.2 | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A024R038 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10385 | BTN2A2 | LZE4T | Human | Esophagus | ESCC | 2.18e-06 | 2.24e-01 | 0.0811 |
10385 | BTN2A2 | LZE24T | Human | Esophagus | ESCC | 3.17e-06 | 1.69e-01 | 0.0596 |
10385 | BTN2A2 | LZE6T | Human | Esophagus | ESCC | 2.96e-03 | 1.63e-01 | 0.0845 |
10385 | BTN2A2 | P2T-E | Human | Esophagus | ESCC | 3.75e-37 | 6.92e-01 | 0.1177 |
10385 | BTN2A2 | P4T-E | Human | Esophagus | ESCC | 6.14e-11 | 2.52e-01 | 0.1323 |
10385 | BTN2A2 | P8T-E | Human | Esophagus | ESCC | 2.44e-04 | 9.75e-02 | 0.0889 |
10385 | BTN2A2 | P10T-E | Human | Esophagus | ESCC | 2.93e-08 | 1.28e-01 | 0.116 |
10385 | BTN2A2 | P11T-E | Human | Esophagus | ESCC | 6.74e-09 | 3.13e-01 | 0.1426 |
10385 | BTN2A2 | P12T-E | Human | Esophagus | ESCC | 5.09e-09 | 1.88e-01 | 0.1122 |
10385 | BTN2A2 | P15T-E | Human | Esophagus | ESCC | 1.31e-02 | 9.05e-02 | 0.1149 |
10385 | BTN2A2 | P16T-E | Human | Esophagus | ESCC | 1.95e-15 | 2.64e-01 | 0.1153 |
10385 | BTN2A2 | P21T-E | Human | Esophagus | ESCC | 1.81e-18 | 3.02e-01 | 0.1617 |
10385 | BTN2A2 | P22T-E | Human | Esophagus | ESCC | 2.06e-02 | 7.21e-02 | 0.1236 |
10385 | BTN2A2 | P23T-E | Human | Esophagus | ESCC | 1.14e-03 | 1.18e-01 | 0.108 |
10385 | BTN2A2 | P24T-E | Human | Esophagus | ESCC | 1.36e-09 | 1.38e-01 | 0.1287 |
10385 | BTN2A2 | P26T-E | Human | Esophagus | ESCC | 4.16e-11 | 1.13e-01 | 0.1276 |
10385 | BTN2A2 | P27T-E | Human | Esophagus | ESCC | 7.46e-15 | 2.06e-01 | 0.1055 |
10385 | BTN2A2 | P28T-E | Human | Esophagus | ESCC | 2.18e-05 | 1.08e-01 | 0.1149 |
10385 | BTN2A2 | P30T-E | Human | Esophagus | ESCC | 1.56e-07 | 2.72e-01 | 0.137 |
10385 | BTN2A2 | P31T-E | Human | Esophagus | ESCC | 7.00e-09 | 1.58e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:00508528 | Esophagus | ESCC | T cell receptor signaling pathway | 73/8552 | 123/18723 | 1.54e-03 | 7.24e-03 | 73 |
GO:000715918 | Esophagus | ESCC | leukocyte cell-cell adhesion | 192/8552 | 371/18723 | 1.03e-02 | 3.51e-02 | 192 |
GO:190303717 | Esophagus | ESCC | regulation of leukocyte cell-cell adhesion | 174/8552 | 336/18723 | 1.36e-02 | 4.43e-02 | 174 |
GO:004211016 | Oral cavity | OSCC | T cell activation | 245/7305 | 487/18723 | 2.00e-07 | 3.22e-06 | 245 |
GO:002240718 | Oral cavity | OSCC | regulation of cell-cell adhesion | 218/7305 | 448/18723 | 1.71e-05 | 1.68e-04 | 218 |
GO:005086315 | Oral cavity | OSCC | regulation of T cell activation | 161/7305 | 329/18723 | 1.44e-04 | 1.02e-03 | 161 |
GO:00508527 | Oral cavity | OSCC | T cell receptor signaling pathway | 68/7305 | 123/18723 | 1.80e-04 | 1.22e-03 | 68 |
GO:000715916 | Oral cavity | OSCC | leukocyte cell-cell adhesion | 178/7305 | 371/18723 | 2.44e-04 | 1.57e-03 | 178 |
GO:190303715 | Oral cavity | OSCC | regulation of leukocyte cell-cell adhesion | 162/7305 | 336/18723 | 3.39e-04 | 2.08e-03 | 162 |
GO:000268310 | Oral cavity | OSCC | negative regulation of immune system process | 204/7305 | 434/18723 | 3.72e-04 | 2.27e-03 | 204 |
GO:004209816 | Oral cavity | OSCC | T cell proliferation | 100/7305 | 199/18723 | 7.93e-04 | 4.27e-03 | 100 |
GO:00071629 | Oral cavity | OSCC | negative regulation of cell adhesion | 145/7305 | 303/18723 | 9.95e-04 | 5.18e-03 | 145 |
GO:00027646 | Oral cavity | OSCC | immune response-regulating signaling pathway | 212/7305 | 468/18723 | 2.93e-03 | 1.27e-02 | 212 |
GO:00706618 | Oral cavity | OSCC | leukocyte proliferation | 145/7305 | 318/18723 | 9.31e-03 | 3.33e-02 | 145 |
GO:00224086 | Oral cavity | OSCC | negative regulation of cell-cell adhesion | 92/7305 | 196/18723 | 1.41e-02 | 4.64e-02 | 92 |
GO:00466517 | Oral cavity | OSCC | lymphocyte proliferation | 131/7305 | 288/18723 | 1.41e-02 | 4.67e-02 | 131 |
GO:000276413 | Oral cavity | EOLP | immune response-regulating signaling pathway | 108/2218 | 468/18723 | 4.04e-12 | 7.34e-10 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTN2A2 | SNV | Missense_Mutation | novel | c.154N>G | p.Thr52Ala | p.T52A | Q8WVV5 | protein_coding | tolerated(0.23) | benign(0.216) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTN2A2 | deletion | Frame_Shift_Del | novel | c.1554delG | p.Thr519ProfsTer17 | p.T519Pfs*17 | Q8WVV5 | protein_coding | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BTN2A2 | deletion | Frame_Shift_Del | c.881delA | p.Lys294ArgfsTer56 | p.K294Rfs*56 | Q8WVV5 | protein_coding | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |||
BTN2A2 | SNV | Missense_Mutation | c.1351N>T | p.Asp451Tyr | p.D451Y | Q8WVV5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-ED-A459-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Ancillary | alvesin | CR | |
BTN2A2 | SNV | Missense_Mutation | novel | c.623C>T | p.Thr208Ile | p.T208I | Q8WVV5 | protein_coding | deleterious(0.02) | possibly_damaging(0.703) | TCGA-ZP-A9CV-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
BTN2A2 | SNV | Missense_Mutation | c.455N>T | p.Lys152Met | p.K152M | Q8WVV5 | protein_coding | deleterious(0.04) | possibly_damaging(0.738) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
BTN2A2 | SNV | Missense_Mutation | rs767620695 | c.1397C>G | p.Ser466Trp | p.S466W | Q8WVV5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
BTN2A2 | SNV | Missense_Mutation | c.139G>T | p.Val47Leu | p.V47L | Q8WVV5 | protein_coding | tolerated(0.08) | benign(0.044) | TCGA-55-7570-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BTN2A2 | SNV | Missense_Mutation | c.383N>T | p.Arg128Leu | p.R128L | Q8WVV5 | protein_coding | tolerated(0.79) | benign(0.107) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
BTN2A2 | SNV | Missense_Mutation | c.527C>T | p.Pro176Leu | p.P176L | Q8WVV5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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