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Gene: BRINP1 |
Gene summary for BRINP1 |
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Gene information | Species | Human | Gene symbol | BRINP1 | Gene ID | 1620 |
Gene name | BMP/retinoic acid inducible neural specific 1 | |
Gene Alias | DBC1 | |
Cytomap | 9q33.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O60477 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1620 | BRINP1 | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.19e-15 | 1.00e+00 | 0.1829 |
1620 | BRINP1 | RNA-P3T-P3T-2 | Human | Lung | IAC | 4.53e-15 | 9.84e-01 | 0.1835 |
1620 | BRINP1 | RNA-P3T-P3T-3 | Human | Lung | IAC | 4.38e-04 | 9.59e-01 | 0.1745 |
1620 | BRINP1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 4.27e-23 | 1.21e+00 | 0.1859 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00073464 | Lung | IAC | regulation of mitotic cell cycle | 78/2061 | 457/18723 | 5.37e-05 | 1.21e-03 | 78 |
GO:00457861 | Lung | IAC | negative regulation of cell cycle | 67/2061 | 385/18723 | 9.74e-05 | 1.93e-03 | 67 |
GO:00459301 | Lung | IAC | negative regulation of mitotic cell cycle | 45/2061 | 235/18723 | 1.49e-04 | 2.73e-03 | 45 |
GO:00507675 | Lung | IAC | regulation of neurogenesis | 57/2061 | 364/18723 | 3.92e-03 | 3.24e-02 | 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRINP1 | SNV | Missense_Mutation | novel | c.2105G>A | p.Arg702Gln | p.R702Q | O60477 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
BRINP1 | SNV | Missense_Mutation | novel | c.1392G>T | p.Gln464His | p.Q464H | O60477 | protein_coding | deleterious(0.05) | possibly_damaging(0.857) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
BRINP1 | SNV | Missense_Mutation | c.2008C>T | p.Arg670Cys | p.R670C | O60477 | protein_coding | deleterious(0) | benign(0.232) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BRINP1 | SNV | Missense_Mutation | rs765012305 | c.1111C>T | p.Arg371Cys | p.R371C | O60477 | protein_coding | tolerated(0.09) | possibly_damaging(0.454) | TCGA-DM-A0X9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BRINP1 | SNV | Missense_Mutation | c.2276N>C | p.Lys759Thr | p.K759T | O60477 | protein_coding | deleterious(0) | possibly_damaging(0.624) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
BRINP1 | SNV | Missense_Mutation | rs151157979 | c.524G>A | p.Arg175His | p.R175H | O60477 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BRINP1 | SNV | Missense_Mutation | c.2159T>C | p.Phe720Ser | p.F720S | O60477 | protein_coding | deleterious(0) | benign(0.054) | TCGA-AF-A56N-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
BRINP1 | SNV | Missense_Mutation | c.749N>C | p.Ile250Thr | p.I250T | O60477 | protein_coding | deleterious(0) | possibly_damaging(0.84) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BRINP1 | SNV | Missense_Mutation | rs866830541 | c.1741N>A | p.Glu581Lys | p.E581K | O60477 | protein_coding | deleterious(0.01) | possibly_damaging(0.899) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BRINP1 | SNV | Missense_Mutation | novel | c.322N>T | p.Leu108Phe | p.L108F | O60477 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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