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Gene: BIN1 |
Gene summary for BIN1 |
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Gene information | Species | Human | Gene symbol | BIN1 | Gene ID | 274 |
Gene name | bridging integrator 1 | |
Gene Alias | AMPH2 | |
Cytomap | 2q14.3 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | A0A024RAG9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
274 | BIN1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.76e-06 | 1.52e-01 | 0.0155 |
274 | BIN1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.74e-07 | 4.14e-01 | -0.0811 |
274 | BIN1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-03 | 2.08e-01 | -0.1954 |
274 | BIN1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.11e-04 | 2.54e-01 | -0.1464 |
274 | BIN1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.81e-03 | 2.09e-01 | -0.1001 |
274 | BIN1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.55e-12 | 5.49e-01 | -0.059 |
274 | BIN1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.58e-17 | 5.03e-01 | 0.096 |
274 | BIN1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.54e-03 | 5.27e-01 | 0.0446 |
274 | BIN1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.70e-06 | 7.87e-01 | 0.0451 |
274 | BIN1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.96e-09 | 6.72e-01 | 0.0528 |
274 | BIN1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.54e-04 | 4.61e-01 | 0.0131 |
274 | BIN1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 6.63e-04 | 5.42e-01 | 0.0171 |
274 | BIN1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.10e-05 | 3.01e-01 | 0.0338 |
274 | BIN1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.10e-22 | 6.00e-01 | 0.0674 |
274 | BIN1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.41e-04 | 4.16e-01 | 0.0112 |
274 | BIN1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.44e-02 | 2.84e-01 | 0.0588 |
274 | BIN1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.94e-18 | 5.82e-01 | 0.294 |
274 | BIN1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.18e-38 | 1.11e+00 | 0.3859 |
274 | BIN1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.54e-32 | 7.35e-01 | 0.3005 |
274 | BIN1 | LZE4T | Human | Esophagus | ESCC | 2.82e-04 | 1.42e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0030838 | Colorectum | AD | positive regulation of actin filament polymerization | 48/3918 | 99/18723 | 9.21e-10 | 7.03e-08 | 48 |
GO:0007034 | Colorectum | AD | vacuolar transport | 60/3918 | 157/18723 | 4.97e-07 | 1.85e-05 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa04666 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa046661 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa046662 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa046663 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa046664 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa046665 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0466620 | Esophagus | ESCC | Fc gamma R-mediated phagocytosis | 63/4205 | 97/8465 | 1.63e-03 | 4.89e-03 | 2.50e-03 | 63 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa04666110 | Esophagus | ESCC | Fc gamma R-mediated phagocytosis | 63/4205 | 97/8465 | 1.63e-03 | 4.89e-03 | 2.50e-03 | 63 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0466610 | Liver | HCC | Fc gamma R-mediated phagocytosis | 58/4020 | 97/8465 | 9.65e-03 | 2.52e-02 | 1.40e-02 | 58 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BIN1 | SNV | Missense_Mutation | novel | c.545N>T | p.Ala182Val | p.A182V | O00499 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BIN1 | SNV | Missense_Mutation | rs756882994 | c.383C>T | p.Thr128Met | p.T128M | O00499 | protein_coding | deleterious(0.03) | benign(0.351) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
BIN1 | SNV | Missense_Mutation | novel | c.504N>C | p.Glu168Asp | p.E168D | O00499 | protein_coding | tolerated(0.2) | benign(0.047) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
BIN1 | SNV | Missense_Mutation | c.273N>T | p.Glu91Asp | p.E91D | O00499 | protein_coding | deleterious(0.04) | benign(0.031) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BIN1 | SNV | Missense_Mutation | c.292N>T | p.Asp98Tyr | p.D98Y | O00499 | protein_coding | deleterious(0) | possibly_damaging(0.793) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD | |
BIN1 | SNV | Missense_Mutation | novel | c.143N>C | p.Val48Ala | p.V48A | O00499 | protein_coding | tolerated(0.11) | possibly_damaging(0.708) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
BIN1 | insertion | Frame_Shift_Ins | novel | c.1375_1376insT | p.Ala459ValfsTer26 | p.A459Vfs*26 | O00499 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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