Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: ATP2C1

Gene summary for ATP2C1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ATP2C1

Gene ID

27032

Gene nameATPase secretory pathway Ca2+ transporting 1
Gene AliasATP2C1A
Cytomap3q22.1
Gene Typeprotein-coding
GO ID

GO:0000041

UniProtAcc

P98194


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
27032ATP2C1CA_HPV_2HumanCervixCC4.48e-022.63e-010.0391
27032ATP2C1CCI_1HumanCervixCC9.64e-047.07e-010.528
27032ATP2C1CCI_2HumanCervixCC6.77e-101.12e+000.5249
27032ATP2C1CCI_3HumanCervixCC1.13e-151.17e+000.516
27032ATP2C1TumorHumanCervixCC6.97e-094.55e-010.1241
27032ATP2C1sample3HumanCervixCC7.38e-164.77e-010.1387
27032ATP2C1T3HumanCervixCC4.87e-124.55e-010.1389
27032ATP2C1HTA11_3410_2000001011HumanColorectumAD1.78e-06-4.23e-010.0155
27032ATP2C1HTA11_3361_2000001011HumanColorectumAD6.82e-03-4.50e-01-0.1207
27032ATP2C1HTA11_696_2000001011HumanColorectumAD1.30e-02-3.87e-01-0.1464
27032ATP2C1HTA11_866_2000001011HumanColorectumAD2.42e-02-3.33e-01-0.1001
27032ATP2C1HTA11_866_3004761011HumanColorectumAD4.02e-04-3.91e-010.096
27032ATP2C1HTA11_10711_2000001011HumanColorectumAD4.33e-03-3.74e-010.0338
27032ATP2C1HTA11_7696_3000711011HumanColorectumAD8.09e-03-3.22e-010.0674
27032ATP2C1HTA11_99999974143_84620HumanColorectumMSS1.12e-12-5.16e-010.3005
27032ATP2C1A015-C-203HumanColorectumFAP2.36e-17-3.35e-01-0.1294
27032ATP2C1A015-C-204HumanColorectumFAP3.63e-04-2.99e-01-0.0228
27032ATP2C1A014-C-040HumanColorectumFAP4.08e-02-3.64e-01-0.1184
27032ATP2C1A002-C-201HumanColorectumFAP3.31e-08-2.85e-010.0324
27032ATP2C1A001-C-119HumanColorectumFAP5.92e-06-3.72e-01-0.1557
Page: 1 2 3 4 5 6 7 8 9 10 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00085446CervixCCepidermis development83/2311324/187233.91e-118.54e-0983
GO:190382910CervixCCpositive regulation of cellular protein localization72/2311276/187233.20e-104.46e-0872
GO:007265910CervixCCprotein localization to plasma membrane73/2311284/187234.95e-106.73e-0873
GO:19907788CervixCCprotein localization to cell periphery78/2311333/187231.22e-089.73e-0778
GO:005122210CervixCCpositive regulation of protein transport72/2311303/187232.36e-081.70e-0672
GO:190495110CervixCCpositive regulation of establishment of protein localization73/2311319/187239.69e-085.25e-0673
GO:19043779CervixCCpositive regulation of protein localization to cell periphery24/231169/187231.21e-064.15e-0524
GO:00315328CervixCCactin cytoskeleton reorganization31/2311107/187233.34e-068.99e-0531
GO:19030788CervixCCpositive regulation of protein localization to plasma membrane21/231162/187238.91e-062.03e-0421
GO:19054778CervixCCpositive regulation of protein localization to membrane29/2311106/187232.29e-054.01e-0429
GO:00988767CervixCCvesicle-mediated transport to the plasma membrane34/2311136/187233.75e-055.91e-0434
GO:00068927CervixCCpost-Golgi vesicle-mediated transport28/2311104/187234.31e-056.61e-0428
GO:00431228CervixCCregulation of I-kappaB kinase/NF-kappaB signaling53/2311249/187234.50e-056.87e-0453
GO:00901509CervixCCestablishment of protein localization to membrane54/2311260/187237.67e-051.05e-0354
GO:19030768CervixCCregulation of protein localization to plasma membrane27/2311104/187231.15e-041.44e-0327
GO:00072497CervixCCI-kappaB kinase/NF-kappaB signaling56/2311281/187231.81e-042.12e-0356
GO:00481938CervixCCGolgi vesicle transport58/2311296/187232.24e-042.54e-0358
GO:19043758CervixCCregulation of protein localization to cell periphery30/2311125/187232.28e-042.56e-0330
GO:19054758CervixCCregulation of protein localization to membrane36/2311175/187231.33e-031.05e-0236
GO:00068936CervixCCGolgi to plasma membrane transport16/231160/187232.00e-031.46e-0216
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ATP2C1SNVMissense_Mutationnovelc.245N>Gp.Lys82Argp.K82RP98194protein_codingtolerated(0.4)benign(0)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
ATP2C1SNVMissense_Mutationc.2393N>Ap.Arg798Hisp.R798HP98194protein_codingdeleterious(0)probably_damaging(1)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
ATP2C1SNVMissense_Mutationnovelc.1652T>Cp.Met551Thrp.M551TP98194protein_codingtolerated(0.07)possibly_damaging(0.669)TCGA-AP-A1DH-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ATP2C1SNVMissense_Mutationnovelc.2390C>Ap.Pro797Hisp.P797HP98194protein_codingdeleterious(0)probably_damaging(1)TCGA-AP-A1DK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ATP2C1SNVMissense_Mutationrs768289092c.1552N>Ap.Glu518Lysp.E518KP98194protein_codingdeleterious(0.01)probably_damaging(0.977)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ATP2C1SNVMissense_Mutationc.2170N>Ap.Glu724Lysp.E724KP98194protein_codingdeleterious(0.02)probably_damaging(0.995)TCGA-AX-A05Z-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapyadriamycinSD
ATP2C1SNVMissense_Mutationc.2202N>Cp.Lys734Asnp.K734NP98194protein_codingdeleterious(0.01)probably_damaging(0.925)TCGA-AX-A0J0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ATP2C1SNVMissense_Mutationc.1774N>Cp.Thr592Prop.T592PP98194protein_codingtolerated(0.26)benign(0.419)TCGA-AX-A1CE-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnspecificPaclitaxelSD
ATP2C1SNVMissense_Mutationc.1694C>Ap.Pro565Hisp.P565HP98194protein_codingdeleterious(0.03)benign(0.049)TCGA-B5-A11U-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
ATP2C1SNVMissense_Mutationnovelc.427N>Ap.Ala143Thrp.A143TP98194protein_codingdeleterious(0)probably_damaging(0.999)TCGA-B5-A1MR-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
Page: 1 2 3 4 5 6 7 8 9 10 11 12 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
27032ATP2C1ENZYME, TRANSPORTER, DRUGGABLE GENOMEENFLURANEENFLURANE
27032ATP2C1ENZYME, TRANSPORTER, DRUGGABLE GENOMEISOFLURANEISOFLURANE
27032ATP2C1ENZYME, TRANSPORTER, DRUGGABLE GENOMESEVOFLURANESEVOFLURANE
27032ATP2C1ENZYME, TRANSPORTER, DRUGGABLE GENOMEISOFLURANEISOFLURANE
27032ATP2C1ENZYME, TRANSPORTER, DRUGGABLE GENOMEENFLURANEENFLURANE
27032ATP2C1ENZYME, TRANSPORTER, DRUGGABLE GENOMESEVOFLURANESEVOFLURANE
27032ATP2C1ENZYME, TRANSPORTER, DRUGGABLE GENOMEDESFLURANEDESFLURANE
27032ATP2C1ENZYME, TRANSPORTER, DRUGGABLE GENOMEDESFLURANEDESFLURANE
Page: 1