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Gene: ATP2B2 |
Gene summary for ATP2B2 |
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Gene information | Species | Human | Gene symbol | ATP2B2 | Gene ID | 491 |
Gene name | ATPase plasma membrane Ca2+ transporting 2 | |
Gene Alias | PMCA2 | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A024R2K6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
491 | ATP2B2 | NAFLD1 | Human | Liver | NAFLD | 8.52e-14 | 8.99e-01 | -0.04 |
491 | ATP2B2 | S41 | Human | Liver | Cirrhotic | 1.22e-05 | 5.15e-01 | -0.0343 |
491 | ATP2B2 | HCC1_Meng | Human | Liver | HCC | 3.45e-53 | 7.70e-02 | 0.0246 |
491 | ATP2B2 | HCC2 | Human | Liver | HCC | 4.73e-04 | 2.03e+00 | 0.5341 |
491 | ATP2B2 | S027 | Human | Liver | HCC | 4.59e-02 | 4.67e-01 | 0.2446 |
491 | ATP2B2 | S028 | Human | Liver | HCC | 1.86e-05 | 3.15e-01 | 0.2503 |
491 | ATP2B2 | S029 | Human | Liver | HCC | 6.93e-12 | 6.52e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP2B2 | SNV | Missense_Mutation | rs765743831 | c.73N>A | p.Gly25Arg | p.G25R | Q01814 | protein_coding | deleterious(0.01) | possibly_damaging(0.791) | TCGA-AF-A56K-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ATP2B2 | SNV | Missense_Mutation | novel | c.659A>G | p.Asp220Gly | p.D220G | Q01814 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP2B2 | SNV | Missense_Mutation | novel | c.257T>G | p.Phe86Cys | p.F86C | Q01814 | protein_coding | deleterious(0.04) | probably_damaging(0.913) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP2B2 | SNV | Missense_Mutation | rs375973812 | c.754N>A | p.Val252Met | p.V252M | Q01814 | protein_coding | tolerated(0.23) | benign(0.19) | TCGA-AG-3902-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP2B2 | SNV | Missense_Mutation | novel | c.3157C>G | p.Pro1053Ala | p.P1053A | Q01814 | protein_coding | tolerated(0.81) | benign(0.013) | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD |
ATP2B2 | SNV | Missense_Mutation | novel | c.1622N>T | p.Ala541Val | p.A541V | Q01814 | protein_coding | deleterious(0.02) | benign(0.146) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ATP2B2 | SNV | Missense_Mutation | novel | c.1256N>G | p.Asp419Gly | p.D419G | Q01814 | protein_coding | tolerated(0.06) | benign(0.119) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP2B2 | insertion | Frame_Shift_Ins | novel | c.1420dupA | p.Met474AsnfsTer15 | p.M474Nfs*15 | Q01814 | protein_coding | TCGA-AA-3870-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | ||
ATP2B2 | deletion | In_Frame_Del | novel | c.1144_1146delNNN | p.Glu382del | p.E382del | Q01814 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ATP2B2 | deletion | Frame_Shift_Del | c.1302delN | p.Val435SerfsTer14 | p.V435Sfs*14 | Q01814 | protein_coding | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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