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Gene: ATG7 |
Gene summary for ATG7 |
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Gene information | Species | Human | Gene symbol | ATG7 | Gene ID | 10533 |
Gene name | autophagy related 7 | |
Gene Alias | APG7-LIKE | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | O95352 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10533 | ATG7 | CCI_1 | Human | Cervix | CC | 1.41e-05 | 7.90e-01 | 0.528 |
10533 | ATG7 | CCI_2 | Human | Cervix | CC | 1.80e-07 | 7.04e-01 | 0.5249 |
10533 | ATG7 | CCI_3 | Human | Cervix | CC | 1.43e-17 | 9.27e-01 | 0.516 |
10533 | ATG7 | CCII_1 | Human | Cervix | CC | 9.01e-03 | 2.36e-01 | 0.3249 |
10533 | ATG7 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.43e-12 | 7.54e-01 | -0.1954 |
10533 | ATG7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.73e-03 | 5.22e-01 | -0.059 |
10533 | ATG7 | A001-C-207 | Human | Colorectum | FAP | 4.06e-02 | -1.90e-01 | 0.1278 |
10533 | ATG7 | A015-C-203 | Human | Colorectum | FAP | 2.10e-31 | -5.47e-01 | -0.1294 |
10533 | ATG7 | A015-C-204 | Human | Colorectum | FAP | 3.87e-06 | -3.35e-01 | -0.0228 |
10533 | ATG7 | A014-C-040 | Human | Colorectum | FAP | 1.45e-04 | -4.51e-01 | -0.1184 |
10533 | ATG7 | A002-C-201 | Human | Colorectum | FAP | 2.08e-14 | -4.10e-01 | 0.0324 |
10533 | ATG7 | A002-C-203 | Human | Colorectum | FAP | 2.96e-03 | -9.38e-02 | 0.2786 |
10533 | ATG7 | A001-C-119 | Human | Colorectum | FAP | 3.80e-08 | -4.93e-01 | -0.1557 |
10533 | ATG7 | A001-C-108 | Human | Colorectum | FAP | 1.39e-18 | -4.09e-01 | -0.0272 |
10533 | ATG7 | A002-C-205 | Human | Colorectum | FAP | 4.24e-24 | -4.99e-01 | -0.1236 |
10533 | ATG7 | A001-C-104 | Human | Colorectum | FAP | 7.71e-04 | -2.89e-01 | 0.0184 |
10533 | ATG7 | A015-C-005 | Human | Colorectum | FAP | 1.34e-05 | -3.13e-01 | -0.0336 |
10533 | ATG7 | A015-C-006 | Human | Colorectum | FAP | 7.43e-22 | -5.81e-01 | -0.0994 |
10533 | ATG7 | A015-C-106 | Human | Colorectum | FAP | 1.13e-08 | -2.83e-01 | -0.0511 |
10533 | ATG7 | A002-C-114 | Human | Colorectum | FAP | 1.89e-25 | -6.04e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:000697910 | Cervix | CC | response to oxidative stress | 102/2311 | 446/18723 | 2.99e-10 | 4.36e-08 | 102 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:005170110 | Cervix | CC | biological process involved in interaction with host | 57/2311 | 203/18723 | 1.18e-09 | 1.41e-07 | 57 |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:004440310 | Cervix | CC | biological process involved in symbiotic interaction | 71/2311 | 290/18723 | 7.94e-09 | 6.98e-07 | 71 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:006219710 | Cervix | CC | cellular response to chemical stress | 76/2311 | 337/18723 | 1.01e-07 | 5.25e-06 | 76 |
GO:003133010 | Cervix | CC | negative regulation of cellular catabolic process | 63/2311 | 262/18723 | 1.10e-07 | 5.68e-06 | 63 |
GO:00075689 | Cervix | CC | aging | 75/2311 | 339/18723 | 2.75e-07 | 1.13e-05 | 75 |
GO:00316689 | Cervix | CC | cellular response to extracellular stimulus | 59/2311 | 246/18723 | 3.03e-07 | 1.24e-05 | 59 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:003459910 | Cervix | CC | cellular response to oxidative stress | 63/2311 | 288/18723 | 3.58e-06 | 9.50e-05 | 63 |
GO:003166710 | Cervix | CC | response to nutrient levels | 92/2311 | 474/18723 | 5.80e-06 | 1.42e-04 | 92 |
GO:00092678 | Cervix | CC | cellular response to starvation | 39/2311 | 156/18723 | 1.04e-05 | 2.32e-04 | 39 |
GO:00425948 | Cervix | CC | response to starvation | 46/2311 | 197/18723 | 1.24e-05 | 2.59e-04 | 46 |
GO:00316698 | Cervix | CC | cellular response to nutrient levels | 49/2311 | 215/18723 | 1.32e-05 | 2.68e-04 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421614 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa0421615 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa04216 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa042161 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa042164 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa042165 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa042166 | Colorectum | CRC | Ferroptosis | 13/1091 | 41/8465 | 1.36e-03 | 1.08e-02 | 7.33e-03 | 13 |
hsa042167 | Colorectum | CRC | Ferroptosis | 13/1091 | 41/8465 | 1.36e-03 | 1.08e-02 | 7.33e-03 | 13 |
hsa041407 | Lung | IAC | Autophagy - animal | 28/1053 | 141/8465 | 7.64e-03 | 3.03e-02 | 2.01e-02 | 28 |
hsa042169 | Lung | IAC | Ferroptosis | 11/1053 | 41/8465 | 9.62e-03 | 3.68e-02 | 2.44e-02 | 11 |
hsa0414012 | Lung | IAC | Autophagy - animal | 28/1053 | 141/8465 | 7.64e-03 | 3.03e-02 | 2.01e-02 | 28 |
hsa0421612 | Lung | IAC | Ferroptosis | 11/1053 | 41/8465 | 9.62e-03 | 3.68e-02 | 2.44e-02 | 11 |
hsa0421622 | Lung | AIS | Ferroptosis | 11/961 | 41/8465 | 4.84e-03 | 2.45e-02 | 1.57e-02 | 11 |
hsa0414022 | Lung | AIS | Autophagy - animal | 26/961 | 141/8465 | 8.23e-03 | 3.71e-02 | 2.37e-02 | 26 |
hsa0421632 | Lung | AIS | Ferroptosis | 11/961 | 41/8465 | 4.84e-03 | 2.45e-02 | 1.57e-02 | 11 |
hsa0414032 | Lung | AIS | Autophagy - animal | 26/961 | 141/8465 | 8.23e-03 | 3.71e-02 | 2.37e-02 | 26 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATG7 | SNV | Missense_Mutation | c.367G>C | p.Glu123Gln | p.E123Q | O95352 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ATG7 | SNV | Missense_Mutation | c.1663G>T | p.Asp555Tyr | p.D555Y | O95352 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-95-A4VK-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
ATG7 | SNV | Missense_Mutation | novel | c.1411N>T | p.Val471Phe | p.V471F | O95352 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-MP-A4T4-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATG7 | SNV | Missense_Mutation | rs374142073 | c.250N>G | p.Ile84Val | p.I84V | O95352 | protein_coding | tolerated(0.55) | benign(0) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATG7 | SNV | Missense_Mutation | rs753893278 | c.1442G>A | p.Arg481Gln | p.R481Q | O95352 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-21-1076-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ATG7 | SNV | Missense_Mutation | c.181G>T | p.Ala61Ser | p.A61S | O95352 | protein_coding | tolerated(0.63) | benign(0.01) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATG7 | SNV | Missense_Mutation | c.167N>T | p.Ser56Phe | p.S56F | O95352 | protein_coding | tolerated(0.09) | benign(0.169) | TCGA-33-4587-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | etoposide | PD | |
ATG7 | SNV | Missense_Mutation | c.2028A>T | p.Leu676Phe | p.L676F | O95352 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-66-2757-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD | |
ATG7 | SNV | Missense_Mutation | novel | c.623N>G | p.Val208Gly | p.V208G | O95352 | protein_coding | tolerated(0.08) | possibly_damaging(0.649) | TCGA-68-7755-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unspecific | SD | |
ATG7 | SNV | Missense_Mutation | novel | c.288N>G | p.Phe96Leu | p.F96L | O95352 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-NC-A5HK-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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