![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ASNSD1 |
Gene summary for ASNSD1 |
![]() |
Gene information | Species | Human | Gene symbol | ASNSD1 | Gene ID | 54529 |
Gene name | asparagine synthetase domain containing 1 | |
Gene Alias | NBLA00058 | |
Cytomap | 2q32.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9NWL6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54529 | ASNSD1 | P1T-E | Human | Esophagus | ESCC | 9.30e-08 | 2.70e-01 | 0.0875 |
54529 | ASNSD1 | P2T-E | Human | Esophagus | ESCC | 1.74e-22 | 3.25e-01 | 0.1177 |
54529 | ASNSD1 | P4T-E | Human | Esophagus | ESCC | 9.98e-31 | 7.12e-01 | 0.1323 |
54529 | ASNSD1 | P5T-E | Human | Esophagus | ESCC | 2.72e-16 | 2.92e-01 | 0.1327 |
54529 | ASNSD1 | P8T-E | Human | Esophagus | ESCC | 1.92e-16 | 3.83e-01 | 0.0889 |
54529 | ASNSD1 | P10T-E | Human | Esophagus | ESCC | 2.68e-14 | 2.55e-01 | 0.116 |
54529 | ASNSD1 | P11T-E | Human | Esophagus | ESCC | 1.08e-15 | 5.35e-01 | 0.1426 |
54529 | ASNSD1 | P12T-E | Human | Esophagus | ESCC | 4.93e-30 | 6.28e-01 | 0.1122 |
54529 | ASNSD1 | P15T-E | Human | Esophagus | ESCC | 5.48e-13 | 4.31e-01 | 0.1149 |
54529 | ASNSD1 | P16T-E | Human | Esophagus | ESCC | 1.53e-21 | 3.45e-01 | 0.1153 |
54529 | ASNSD1 | P17T-E | Human | Esophagus | ESCC | 6.13e-03 | 3.06e-01 | 0.1278 |
54529 | ASNSD1 | P19T-E | Human | Esophagus | ESCC | 4.21e-08 | 5.28e-01 | 0.1662 |
54529 | ASNSD1 | P20T-E | Human | Esophagus | ESCC | 5.39e-16 | 3.63e-01 | 0.1124 |
54529 | ASNSD1 | P21T-E | Human | Esophagus | ESCC | 2.45e-20 | 4.65e-01 | 0.1617 |
54529 | ASNSD1 | P22T-E | Human | Esophagus | ESCC | 1.83e-33 | 6.29e-01 | 0.1236 |
54529 | ASNSD1 | P23T-E | Human | Esophagus | ESCC | 7.78e-61 | 1.50e+00 | 0.108 |
54529 | ASNSD1 | P24T-E | Human | Esophagus | ESCC | 1.19e-13 | 3.30e-01 | 0.1287 |
54529 | ASNSD1 | P26T-E | Human | Esophagus | ESCC | 3.18e-17 | 3.93e-01 | 0.1276 |
54529 | ASNSD1 | P27T-E | Human | Esophagus | ESCC | 1.11e-16 | 2.79e-01 | 0.1055 |
54529 | ASNSD1 | P28T-E | Human | Esophagus | ESCC | 8.73e-16 | 3.67e-01 | 0.1149 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00086525 | Esophagus | ESCC | cellular amino acid biosynthetic process | 51/8552 | 76/18723 | 1.30e-04 | 8.88e-04 | 51 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:19016075 | Esophagus | ESCC | alpha-amino acid biosynthetic process | 45/8552 | 68/18723 | 5.13e-04 | 2.84e-03 | 45 |
GO:00090674 | Esophagus | ESCC | aspartate family amino acid biosynthetic process | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:001605321 | Liver | HCC | organic acid biosynthetic process | 200/7958 | 316/18723 | 5.24e-14 | 3.22e-12 | 200 |
GO:004639421 | Liver | HCC | carboxylic acid biosynthetic process | 198/7958 | 314/18723 | 1.19e-13 | 6.78e-12 | 198 |
GO:00086522 | Liver | HCC | cellular amino acid biosynthetic process | 58/7958 | 76/18723 | 1.98e-09 | 5.63e-08 | 58 |
GO:19016052 | Liver | HCC | alpha-amino acid metabolic process | 124/7958 | 195/18723 | 2.07e-09 | 5.79e-08 | 124 |
GO:19016072 | Liver | HCC | alpha-amino acid biosynthetic process | 53/7958 | 68/18723 | 2.62e-09 | 7.16e-08 | 53 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:00090672 | Liver | HCC | aspartate family amino acid biosynthetic process | 19/7958 | 21/18723 | 6.44e-06 | 7.84e-05 | 19 |
GO:00090662 | Liver | HCC | aspartate family amino acid metabolic process | 34/7958 | 49/18723 | 1.28e-04 | 1.06e-03 | 34 |
GO:0009064 | Liver | HCC | glutamine family amino acid metabolic process | 47/7958 | 78/18723 | 1.17e-03 | 6.54e-03 | 47 |
GO:00160537 | Oral cavity | OSCC | organic acid biosynthetic process | 155/7305 | 316/18723 | 1.64e-04 | 1.13e-03 | 155 |
GO:00463947 | Oral cavity | OSCC | carboxylic acid biosynthetic process | 154/7305 | 314/18723 | 1.73e-04 | 1.19e-03 | 154 |
GO:00086524 | Oral cavity | OSCC | cellular amino acid biosynthetic process | 42/7305 | 76/18723 | 2.93e-03 | 1.27e-02 | 42 |
GO:19016074 | Oral cavity | OSCC | alpha-amino acid biosynthetic process | 37/7305 | 68/18723 | 7.09e-03 | 2.63e-02 | 37 |
GO:190160711 | Oral cavity | LP | alpha-amino acid biosynthetic process | 28/4623 | 68/18723 | 2.01e-03 | 1.49e-02 | 28 |
GO:000865211 | Oral cavity | LP | cellular amino acid biosynthetic process | 30/4623 | 76/18723 | 3.07e-03 | 2.09e-02 | 30 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASNSD1 | SNV | Missense_Mutation | novel | c.450N>T | p.Leu150Phe | p.L150F | Q9NWL6 | protein_coding | tolerated(0.1) | possibly_damaging(0.715) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ASNSD1 | SNV | Missense_Mutation | novel | c.991G>T | p.Asp331Tyr | p.D331Y | Q9NWL6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-22-4609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASNSD1 | SNV | Missense_Mutation | c.1277N>T | p.Asn426Ile | p.N426I | Q9NWL6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-22-5483-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD | |
ASNSD1 | SNV | Missense_Mutation | novel | c.1405N>G | p.Arg469Gly | p.R469G | Q9NWL6 | protein_coding | deleterious(0.01) | benign(0.381) | TCGA-37-4141-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ASNSD1 | SNV | Missense_Mutation | novel | c.338C>T | p.Ser113Leu | p.S113L | Q9NWL6 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-85-A4QR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASNSD1 | SNV | Missense_Mutation | novel | c.1789N>A | p.Ala597Thr | p.A597T | Q9NWL6 | protein_coding | tolerated(0.26) | benign(0.39) | TCGA-98-A53B-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASNSD1 | SNV | Missense_Mutation | novel | c.138N>T | p.Gln46His | p.Q46H | Q9NWL6 | protein_coding | tolerated(0.39) | benign(0.001) | TCGA-CV-6945-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ASNSD1 | SNV | Missense_Mutation | rs755759127 | c.98N>G | p.Asn33Ser | p.N33S | Q9NWL6 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-IQ-A6SG-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ASNSD1 | SNV | Missense_Mutation | c.466N>G | p.Leu156Val | p.L156V | Q9NWL6 | protein_coding | tolerated(0.05) | possibly_damaging(0.817) | TCGA-KK-A6E8-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | |
ASNSD1 | SNV | Missense_Mutation | novel | c.844N>A | p.Val282Ile | p.V282I | Q9NWL6 | protein_coding | tolerated(0.36) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |