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Gene: ASL |
Gene summary for ASL |
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Gene information | Species | Human | Gene symbol | ASL | Gene ID | 435 |
Gene name | argininosuccinate lyase | |
Gene Alias | ASAL | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000050 | UniProtAcc | A0A024RDL8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
435 | ASL | HTA11_78_2000001011 | Human | Colorectum | AD | 3.70e-03 | 3.94e-01 | -0.1088 |
435 | ASL | HTA11_347_2000001011 | Human | Colorectum | AD | 4.54e-14 | 5.05e-01 | -0.1954 |
435 | ASL | HTA11_411_2000001011 | Human | Colorectum | SER | 6.60e-04 | 7.63e-01 | -0.2602 |
435 | ASL | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.00e-05 | 8.24e-01 | -0.2196 |
435 | ASL | HTA11_83_2000001011 | Human | Colorectum | SER | 4.88e-13 | 8.55e-01 | -0.1526 |
435 | ASL | HTA11_696_2000001011 | Human | Colorectum | AD | 1.31e-20 | 6.21e-01 | -0.1464 |
435 | ASL | HTA11_866_2000001011 | Human | Colorectum | AD | 2.06e-09 | 4.33e-01 | -0.1001 |
435 | ASL | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.09e-13 | 7.13e-01 | -0.059 |
435 | ASL | A015-C-203 | Human | Colorectum | FAP | 3.00e-04 | -1.75e-01 | -0.1294 |
435 | ASL | A002-C-201 | Human | Colorectum | FAP | 4.57e-02 | -1.32e-01 | 0.0324 |
435 | ASL | A002-C-205 | Human | Colorectum | FAP | 1.02e-02 | -1.03e-01 | -0.1236 |
435 | ASL | A015-C-006 | Human | Colorectum | FAP | 4.99e-02 | -1.72e-01 | -0.0994 |
435 | ASL | A015-C-104 | Human | Colorectum | FAP | 1.15e-03 | -1.39e-01 | -0.1899 |
435 | ASL | A002-C-016 | Human | Colorectum | FAP | 2.24e-03 | -1.24e-01 | 0.0521 |
435 | ASL | A002-C-116 | Human | Colorectum | FAP | 2.75e-04 | -9.45e-02 | -0.0452 |
435 | ASL | A018-E-020 | Human | Colorectum | FAP | 5.67e-03 | -1.51e-01 | -0.2034 |
435 | ASL | LZE2T | Human | Esophagus | ESCC | 4.36e-10 | 9.24e-01 | 0.082 |
435 | ASL | LZE4T | Human | Esophagus | ESCC | 2.15e-04 | 2.10e-01 | 0.0811 |
435 | ASL | LZE5T | Human | Esophagus | ESCC | 2.23e-03 | 2.10e-01 | 0.0514 |
435 | ASL | LZE7T | Human | Esophagus | ESCC | 7.51e-10 | 3.26e-01 | 0.0667 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0030838 | Colorectum | AD | positive regulation of actin filament polymerization | 48/3918 | 99/18723 | 9.21e-10 | 7.03e-08 | 48 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01230 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa012301 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa012302 | Colorectum | SER | Biosynthesis of amino acids | 23/1580 | 75/8465 | 8.11e-03 | 4.14e-02 | 3.01e-02 | 23 |
hsa012303 | Colorectum | SER | Biosynthesis of amino acids | 23/1580 | 75/8465 | 8.11e-03 | 4.14e-02 | 3.01e-02 | 23 |
hsa0123023 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0123033 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa012304 | Liver | Cirrhotic | Biosynthesis of amino acids | 35/2530 | 75/8465 | 1.54e-03 | 7.83e-03 | 4.83e-03 | 35 |
hsa0123011 | Liver | Cirrhotic | Biosynthesis of amino acids | 35/2530 | 75/8465 | 1.54e-03 | 7.83e-03 | 4.83e-03 | 35 |
hsa0123021 | Liver | HCC | Biosynthesis of amino acids | 53/4020 | 75/8465 | 3.79e-05 | 2.11e-04 | 1.18e-04 | 53 |
hsa0123031 | Liver | HCC | Biosynthesis of amino acids | 53/4020 | 75/8465 | 3.79e-05 | 2.11e-04 | 1.18e-04 | 53 |
hsa012305 | Oral cavity | OSCC | Biosynthesis of amino acids | 45/3704 | 75/8465 | 3.27e-03 | 8.23e-03 | 4.19e-03 | 45 |
hsa0123012 | Oral cavity | OSCC | Biosynthesis of amino acids | 45/3704 | 75/8465 | 3.27e-03 | 8.23e-03 | 4.19e-03 | 45 |
hsa00220 | Stomach | GC | Arginine biosynthesis | 6/708 | 22/8465 | 7.81e-03 | 4.10e-02 | 2.88e-02 | 6 |
hsa002201 | Stomach | GC | Arginine biosynthesis | 6/708 | 22/8465 | 7.81e-03 | 4.10e-02 | 2.88e-02 | 6 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASL | SNV | Missense_Mutation | c.1172C>A | p.Ser391Tyr | p.S391Y | P04424 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-66-2794-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ASL | SNV | Missense_Mutation | novel | c.94N>T | p.Arg32Trp | p.R32W | P04424 | protein_coding | tolerated(0.06) | benign(0.02) | TCGA-85-8479-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASL | SNV | Missense_Mutation | novel | c.529N>T | p.Ala177Ser | p.A177S | P04424 | protein_coding | deleterious(0.02) | possibly_damaging(0.689) | TCGA-CN-A497-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ASL | SNV | Missense_Mutation | rs139410488 | c.1342N>A | p.Val448Ile | p.V448I | P04424 | protein_coding | tolerated(0.17) | benign(0.022) | TCGA-CV-A45O-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ASL | SNV | Missense_Mutation | c.917N>T | p.Arg306Leu | p.R306L | P04424 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-EJ-7331-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
ASL | SNV | Missense_Mutation | novel | c.539N>C | p.Leu180Pro | p.L180P | P04424 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-J4-A6M7-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
ASL | SNV | Missense_Mutation | rs775839623 | c.76G>A | p.Ala26Thr | p.A26T | P04424 | protein_coding | tolerated(0.17) | benign(0.062) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASL | SNV | Missense_Mutation | rs768087423 | c.308N>T | p.Thr103Met | p.T103M | P04424 | protein_coding | deleterious(0.02) | possibly_damaging(0.712) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASL | SNV | Missense_Mutation | rs757216794 | c.1210G>A | p.Ala404Thr | p.A404T | P04424 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ASL | SNV | Missense_Mutation | rs757216794 | c.1210G>A | p.Ala404Thr | p.A404T | P04424 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
435 | ASL | ENZYME | sodium benzoate / sodium phenylacetate |
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