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Gene: ARMC3 |
Gene summary for ARMC3 |
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Gene information | Species | Human | Gene symbol | ARMC3 | Gene ID | 219681 |
Gene name | armadillo repeat containing 3 | |
Gene Alias | CT81 | |
Cytomap | 10p12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5W041 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219681 | ARMC3 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.00e-03 | 7.47e-01 | -0.0238 |
219681 | ARMC3 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 4.12e-03 | 6.53e-01 | -0.0186 |
219681 | ARMC3 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.47e-02 | 7.14e-01 | -0.0296 |
219681 | ARMC3 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.24e-04 | 7.21e-01 | -0.0263 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARMC3 | SNV | Missense_Mutation | c.674G>A | p.Arg225Gln | p.R225Q | Q5W041 | protein_coding | deleterious(0.05) | benign(0.069) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARMC3 | SNV | Missense_Mutation | c.1880N>A | p.Ser627Asn | p.S627N | Q5W041 | protein_coding | tolerated(0.27) | benign(0.169) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARMC3 | SNV | Missense_Mutation | novel | c.2578N>C | p.Lys860Gln | p.K860Q | Q5W041 | protein_coding | deleterious(0.04) | probably_damaging(0.976) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ARMC3 | SNV | Missense_Mutation | rs199547387 | c.1346G>A | p.Arg449His | p.R449H | Q5W041 | protein_coding | tolerated(0.37) | benign(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARMC3 | SNV | Missense_Mutation | c.758N>T | p.Ala253Val | p.A253V | Q5W041 | protein_coding | tolerated(0.07) | probably_damaging(0.978) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
ARMC3 | SNV | Missense_Mutation | c.1582N>A | p.Glu528Lys | p.E528K | Q5W041 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
ARMC3 | SNV | Missense_Mutation | c.2169C>A | p.Phe723Leu | p.F723L | Q5W041 | protein_coding | tolerated(1) | benign(0.007) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
ARMC3 | SNV | Missense_Mutation | novel | c.461N>A | p.Pro154Gln | p.P154Q | Q5W041 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARMC3 | SNV | Missense_Mutation | novel | c.892N>A | p.Ala298Thr | p.A298T | Q5W041 | protein_coding | deleterious(0.02) | probably_damaging(0.945) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARMC3 | SNV | Missense_Mutation | rs572510134 | c.1261N>A | p.Val421Ile | p.V421I | Q5W041 | protein_coding | tolerated(0.05) | possibly_damaging(0.73) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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