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Gene: ARID2 |
Gene summary for ARID2 |
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Gene information | Species | Human | Gene symbol | ARID2 | Gene ID | 196528 |
Gene name | AT-rich interaction domain 2 | |
Gene Alias | BAF200 | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q68CP9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
196528 | ARID2 | CCI_1 | Human | Cervix | CC | 1.28e-09 | 7.48e-01 | 0.528 |
196528 | ARID2 | CCI_2 | Human | Cervix | CC | 7.81e-13 | 1.57e+00 | 0.5249 |
196528 | ARID2 | CCI_3 | Human | Cervix | CC | 4.37e-13 | 9.62e-01 | 0.516 |
196528 | ARID2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.57e-16 | -6.45e-01 | 0.0155 |
196528 | ARID2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.19e-02 | -4.54e-01 | -0.1207 |
196528 | ARID2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.73e-04 | -7.72e-01 | -0.2061 |
196528 | ARID2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.18e-02 | -6.02e-01 | -0.1462 |
196528 | ARID2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.15e-04 | -6.60e-01 | -0.0179 |
196528 | ARID2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.58e-13 | -5.35e-01 | 0.096 |
196528 | ARID2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.63e-04 | -4.50e-01 | 0.0338 |
196528 | ARID2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.43e-09 | -4.10e-01 | 0.0674 |
196528 | ARID2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.01e-07 | -3.58e-01 | 0.294 |
196528 | ARID2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.62e-02 | 7.36e-01 | 0.3487 |
196528 | ARID2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.30e-18 | -5.55e-01 | 0.3005 |
196528 | ARID2 | F007 | Human | Colorectum | FAP | 4.48e-02 | -2.25e-01 | 0.1176 |
196528 | ARID2 | A001-C-207 | Human | Colorectum | FAP | 1.46e-03 | -2.33e-01 | 0.1278 |
196528 | ARID2 | A015-C-203 | Human | Colorectum | FAP | 3.78e-34 | -5.22e-01 | -0.1294 |
196528 | ARID2 | A015-C-204 | Human | Colorectum | FAP | 1.89e-06 | -3.37e-01 | -0.0228 |
196528 | ARID2 | A014-C-040 | Human | Colorectum | FAP | 1.45e-04 | -2.68e-01 | -0.1184 |
196528 | ARID2 | A002-C-201 | Human | Colorectum | FAP | 2.71e-16 | -4.04e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:00512713 | Cervix | CC | negative regulation of cellular component movement | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00400133 | Cervix | CC | negative regulation of locomotion | 76/2311 | 391/18723 | 3.47e-05 | 5.60e-04 | 76 |
GO:20001463 | Cervix | CC | negative regulation of cell motility | 71/2311 | 359/18723 | 3.47e-05 | 5.60e-04 | 71 |
GO:00488634 | Cervix | CC | stem cell differentiation | 46/2311 | 206/18723 | 4.11e-05 | 6.36e-04 | 46 |
GO:00303363 | Cervix | CC | negative regulation of cell migration | 68/2311 | 344/18723 | 5.11e-05 | 7.70e-04 | 68 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:00605375 | Cervix | CC | muscle tissue development | 76/2311 | 403/18723 | 9.76e-05 | 1.27e-03 | 76 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00147064 | Cervix | CC | striated muscle tissue development | 72/2311 | 384/18723 | 1.76e-04 | 2.07e-03 | 72 |
GO:20010209 | Cervix | CC | regulation of response to DNA damage stimulus | 46/2311 | 219/18723 | 1.92e-04 | 2.23e-03 | 46 |
GO:00610089 | Cervix | CC | hepaticobiliary system development | 34/2311 | 150/18723 | 2.92e-04 | 3.14e-03 | 34 |
GO:00018899 | Cervix | CC | liver development | 33/2311 | 147/18723 | 4.27e-04 | 4.30e-03 | 33 |
GO:0033002 | Cervix | CC | muscle cell proliferation | 49/2311 | 248/18723 | 5.43e-04 | 5.24e-03 | 49 |
GO:00349685 | Cervix | CC | histone lysine methylation | 27/2311 | 115/18723 | 6.61e-04 | 6.09e-03 | 27 |
GO:00486386 | Cervix | CC | regulation of developmental growth | 61/2311 | 330/18723 | 7.69e-04 | 6.85e-03 | 61 |
GO:00310565 | Cervix | CC | regulation of histone modification | 33/2311 | 152/18723 | 7.97e-04 | 7.00e-03 | 33 |
GO:00510528 | Cervix | CC | regulation of DNA metabolic process | 65/2311 | 359/18723 | 9.25e-04 | 7.84e-03 | 65 |
GO:00165715 | Cervix | CC | histone methylation | 30/2311 | 141/18723 | 1.88e-03 | 1.39e-02 | 30 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0522510 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
hsa0522513 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
hsa05225 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
hsa052251 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
hsa052252 | Colorectum | MSS | Hepatocellular carcinoma | 56/1875 | 168/8465 | 5.04e-04 | 3.45e-03 | 2.11e-03 | 56 |
hsa052253 | Colorectum | MSS | Hepatocellular carcinoma | 56/1875 | 168/8465 | 5.04e-04 | 3.45e-03 | 2.11e-03 | 56 |
hsa052254 | Colorectum | FAP | Hepatocellular carcinoma | 43/1404 | 168/8465 | 1.78e-03 | 8.99e-03 | 5.47e-03 | 43 |
hsa052255 | Colorectum | FAP | Hepatocellular carcinoma | 43/1404 | 168/8465 | 1.78e-03 | 8.99e-03 | 5.47e-03 | 43 |
hsa052256 | Colorectum | CRC | Hepatocellular carcinoma | 37/1091 | 168/8465 | 6.38e-04 | 5.89e-03 | 3.99e-03 | 37 |
hsa052257 | Colorectum | CRC | Hepatocellular carcinoma | 37/1091 | 168/8465 | 6.38e-04 | 5.89e-03 | 3.99e-03 | 37 |
hsa0522518 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa0522519 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa052259 | Lung | IAC | Hepatocellular carcinoma | 33/1053 | 168/8465 | 4.77e-03 | 2.15e-02 | 1.43e-02 | 33 |
hsa0522512 | Lung | IAC | Hepatocellular carcinoma | 33/1053 | 168/8465 | 4.77e-03 | 2.15e-02 | 1.43e-02 | 33 |
hsa0522521 | Lung | AIS | Hepatocellular carcinoma | 31/961 | 168/8465 | 4.11e-03 | 2.15e-02 | 1.38e-02 | 31 |
hsa0522531 | Lung | AIS | Hepatocellular carcinoma | 31/961 | 168/8465 | 4.11e-03 | 2.15e-02 | 1.38e-02 | 31 |
hsa0522516 | Oral cavity | OSCC | Hepatocellular carcinoma | 97/3704 | 168/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 97 |
hsa0522517 | Oral cavity | OSCC | Hepatocellular carcinoma | 97/3704 | 168/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 97 |
hsa0522523 | Oral cavity | EOLP | Hepatocellular carcinoma | 39/1218 | 168/8465 | 1.35e-03 | 4.80e-03 | 2.83e-03 | 39 |
hsa0522533 | Oral cavity | EOLP | Hepatocellular carcinoma | 39/1218 | 168/8465 | 1.35e-03 | 4.80e-03 | 2.83e-03 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARID2 | SNV | Missense_Mutation | rs529386166 | c.3319N>A | p.Ala1107Thr | p.A1107T | Q68CP9 | protein_coding | tolerated_low_confidence(0.56) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARID2 | SNV | Missense_Mutation | novel | c.1199N>G | p.Tyr400Cys | p.Y400C | Q68CP9 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARID2 | SNV | Missense_Mutation | novel | c.5218G>A | p.Ala1740Thr | p.A1740T | Q68CP9 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARID2 | SNV | Missense_Mutation | c.1418N>A | p.Ser473Tyr | p.S473Y | Q68CP9 | protein_coding | deleterious(0.02) | possibly_damaging(0.467) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARID2 | SNV | Missense_Mutation | c.535N>A | p.Val179Ile | p.V179I | Q68CP9 | protein_coding | deleterious(0.03) | probably_damaging(0.972) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ARID2 | SNV | Missense_Mutation | c.2864N>T | p.Pro955Leu | p.P955L | Q68CP9 | protein_coding | deleterious_low_confidence(0.01) | benign(0.165) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARID2 | SNV | Missense_Mutation | rs752984515 | c.3806C>T | p.Pro1269Leu | p.P1269L | Q68CP9 | protein_coding | deleterious_low_confidence(0) | benign(0.357) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARID2 | SNV | Missense_Mutation | novel | c.685N>T | p.Thr229Ser | p.T229S | Q68CP9 | protein_coding | tolerated(0.44) | benign(0.069) | TCGA-SS-A7HO-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | PD |
ARID2 | SNV | Missense_Mutation | c.1673N>A | p.Arg558His | p.R558H | Q68CP9 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARID2 | SNV | Missense_Mutation | novel | c.1814N>A | p.Pro605Gln | p.P605Q | Q68CP9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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