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Gene: ARHGAP30 |
Gene summary for ARHGAP30 |
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Gene information | Species | Human | Gene symbol | ARHGAP30 | Gene ID | 257106 |
Gene name | Rho GTPase activating protein 30 | |
Gene Alias | ARHGAP30 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q7Z6I6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
257106 | ARHGAP30 | C21 | Human | Oral cavity | OSCC | 7.83e-05 | 1.75e-01 | 0.2678 |
257106 | ARHGAP30 | C38 | Human | Oral cavity | OSCC | 7.06e-07 | 6.15e-01 | 0.172 |
257106 | ARHGAP30 | C46 | Human | Oral cavity | OSCC | 1.78e-04 | 1.60e-01 | 0.1673 |
257106 | ARHGAP30 | C57 | Human | Oral cavity | OSCC | 1.43e-12 | 2.87e-01 | 0.1679 |
257106 | ARHGAP30 | C06 | Human | Oral cavity | OSCC | 1.76e-03 | 5.21e-01 | 0.2699 |
257106 | ARHGAP30 | LN46 | Human | Oral cavity | OSCC | 2.08e-04 | 1.20e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP30 | SNV | Missense_Mutation | novel | c.2267N>G | p.Glu756Gly | p.E756G | Q7Z6I6 | protein_coding | tolerated_low_confidence(0.07) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | rs538155601 | c.2603C>T | p.Ala868Val | p.A868V | Q7Z6I6 | protein_coding | tolerated_low_confidence(0.3) | benign(0) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | rs538155601 | c.2603N>T | p.Ala868Val | p.A868V | Q7Z6I6 | protein_coding | tolerated_low_confidence(0.3) | benign(0) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | novel | c.1370N>A | p.Ser457Asn | p.S457N | Q7Z6I6 | protein_coding | tolerated(0.32) | benign(0.001) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | novel | c.2340G>T | p.Glu780Asp | p.E780D | Q7Z6I6 | protein_coding | tolerated_low_confidence(0.05) | benign(0.111) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ARHGAP30 | SNV | Missense_Mutation | c.3007C>A | p.Leu1003Ile | p.L1003I | Q7Z6I6 | protein_coding | deleterious_low_confidence(0) | benign(0.211) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP30 | SNV | Missense_Mutation | c.2909G>A | p.Arg970Gln | p.R970Q | Q7Z6I6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.703) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP30 | SNV | Missense_Mutation | rs748205506 | c.2768G>A | p.Arg923His | p.R923H | Q7Z6I6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | novel | c.236G>A | p.Arg79His | p.R79H | Q7Z6I6 | protein_coding | tolerated(0.06) | probably_damaging(0.98) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP30 | SNV | Missense_Mutation | c.2182A>C | p.Ser728Arg | p.S728R | Q7Z6I6 | protein_coding | deleterious_low_confidence(0.03) | benign(0.001) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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