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Gene: AP2M1 |
Gene summary for AP2M1 |
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Gene information | Species | Human | Gene symbol | AP2M1 | Gene ID | 1173 |
Gene name | adaptor related protein complex 2 subunit mu 1 | |
Gene Alias | AP50 | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0002090 | UniProtAcc | Q96CW1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1173 | AP2M1 | GSM4909281 | Human | Breast | IDC | 3.07e-26 | 6.98e-01 | 0.21 |
1173 | AP2M1 | GSM4909282 | Human | Breast | IDC | 1.15e-14 | 5.71e-01 | -0.0288 |
1173 | AP2M1 | GSM4909285 | Human | Breast | IDC | 1.13e-46 | 9.11e-01 | 0.21 |
1173 | AP2M1 | GSM4909288 | Human | Breast | IDC | 4.19e-03 | 1.77e-01 | 0.0988 |
1173 | AP2M1 | GSM4909293 | Human | Breast | IDC | 1.22e-05 | 3.57e-01 | 0.1581 |
1173 | AP2M1 | GSM4909294 | Human | Breast | IDC | 3.12e-04 | -1.73e-02 | 0.2022 |
1173 | AP2M1 | GSM4909296 | Human | Breast | IDC | 5.29e-11 | -1.27e-01 | 0.1524 |
1173 | AP2M1 | GSM4909297 | Human | Breast | IDC | 8.49e-17 | 6.05e-02 | 0.1517 |
1173 | AP2M1 | GSM4909301 | Human | Breast | IDC | 1.19e-07 | -2.86e-01 | 0.1577 |
1173 | AP2M1 | GSM4909304 | Human | Breast | IDC | 2.16e-10 | 4.76e-01 | 0.1636 |
1173 | AP2M1 | GSM4909311 | Human | Breast | IDC | 1.00e-34 | -1.23e-01 | 0.1534 |
1173 | AP2M1 | GSM4909312 | Human | Breast | IDC | 3.84e-16 | 1.23e-01 | 0.1552 |
1173 | AP2M1 | GSM4909316 | Human | Breast | IDC | 5.55e-04 | 3.22e-01 | 0.21 |
1173 | AP2M1 | GSM4909318 | Human | Breast | IDC | 1.88e-04 | 3.06e-01 | 0.2031 |
1173 | AP2M1 | GSM4909319 | Human | Breast | IDC | 3.33e-47 | -1.90e-01 | 0.1563 |
1173 | AP2M1 | GSM4909320 | Human | Breast | IDC | 1.89e-08 | -3.68e-01 | 0.1575 |
1173 | AP2M1 | GSM4909321 | Human | Breast | IDC | 2.18e-21 | 2.14e-01 | 0.1559 |
1173 | AP2M1 | brca2 | Human | Breast | Precancer | 1.60e-02 | 3.16e-01 | -0.024 |
1173 | AP2M1 | M2 | Human | Breast | IDC | 1.48e-08 | 5.01e-01 | 0.21 |
1173 | AP2M1 | NCCBC14 | Human | Breast | DCIS | 1.21e-11 | 2.14e-01 | 0.2021 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069009 | Breast | Precancer | vesicle budding from membrane | 12/1080 | 61/18723 | 1.61e-04 | 2.69e-03 | 12 |
GO:00068986 | Breast | Precancer | receptor-mediated endocytosis | 27/1080 | 244/18723 | 9.01e-04 | 1.03e-02 | 27 |
GO:00458076 | Breast | Precancer | positive regulation of endocytosis | 14/1080 | 100/18723 | 1.77e-03 | 1.74e-02 | 14 |
GO:00316235 | Breast | Precancer | receptor internalization | 15/1080 | 113/18723 | 2.11e-03 | 2.00e-02 | 15 |
GO:00482606 | Breast | Precancer | positive regulation of receptor-mediated endocytosis | 9/1080 | 52/18723 | 2.67e-03 | 2.36e-02 | 9 |
GO:19043757 | Breast | Precancer | regulation of protein localization to cell periphery | 15/1080 | 125/18723 | 5.58e-03 | 4.07e-02 | 15 |
GO:19054757 | Breast | Precancer | regulation of protein localization to membrane | 19/1080 | 175/18723 | 5.98e-03 | 4.22e-02 | 19 |
GO:19030767 | Breast | Precancer | regulation of protein localization to plasma membrane | 13/1080 | 104/18723 | 6.79e-03 | 4.65e-02 | 13 |
GO:190547513 | Breast | IDC | regulation of protein localization to membrane | 28/1434 | 175/18723 | 1.56e-04 | 2.71e-03 | 28 |
GO:000689813 | Breast | IDC | receptor-mediated endocytosis | 35/1434 | 244/18723 | 2.38e-04 | 3.75e-03 | 35 |
GO:004580713 | Breast | IDC | positive regulation of endocytosis | 18/1434 | 100/18723 | 5.40e-04 | 6.96e-03 | 18 |
GO:003162311 | Breast | IDC | receptor internalization | 19/1434 | 113/18723 | 9.17e-04 | 1.05e-02 | 19 |
GO:000690014 | Breast | IDC | vesicle budding from membrane | 12/1434 | 61/18723 | 2.01e-03 | 1.90e-02 | 12 |
GO:190307613 | Breast | IDC | regulation of protein localization to plasma membrane | 17/1434 | 104/18723 | 2.28e-03 | 2.09e-02 | 17 |
GO:00325358 | Breast | IDC | regulation of cellular component size | 45/1434 | 383/18723 | 2.72e-03 | 2.41e-02 | 45 |
GO:190437513 | Breast | IDC | regulation of protein localization to cell periphery | 19/1434 | 125/18723 | 3.06e-03 | 2.60e-02 | 19 |
GO:00431126 | Breast | IDC | receptor metabolic process | 23/1434 | 166/18723 | 4.04e-03 | 3.25e-02 | 23 |
GO:004826013 | Breast | IDC | positive regulation of receptor-mediated endocytosis | 10/1434 | 52/18723 | 5.49e-03 | 4.03e-02 | 10 |
GO:00301007 | Breast | IDC | regulation of endocytosis | 27/1434 | 211/18723 | 5.92e-03 | 4.26e-02 | 27 |
GO:00726599 | Breast | IDC | protein localization to plasma membrane | 34/1434 | 284/18723 | 6.33e-03 | 4.47e-02 | 34 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0496110 | Breast | Precancer | Endocrine and other factor-regulated calcium reabsorption | 11/684 | 53/8465 | 2.92e-03 | 1.81e-02 | 1.39e-02 | 11 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0496111 | Breast | Precancer | Endocrine and other factor-regulated calcium reabsorption | 11/684 | 53/8465 | 2.92e-03 | 1.81e-02 | 1.39e-02 | 11 |
hsa0501643 | Breast | DCIS | Huntington disease | 101/846 | 306/8465 | 1.54e-29 | 1.24e-27 | 9.13e-28 | 101 |
hsa0496141 | Breast | DCIS | Endocrine and other factor-regulated calcium reabsorption | 12/846 | 53/8465 | 5.17e-03 | 2.69e-02 | 1.98e-02 | 12 |
hsa0414416 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0501653 | Breast | DCIS | Huntington disease | 101/846 | 306/8465 | 1.54e-29 | 1.24e-27 | 9.13e-28 | 101 |
hsa0496151 | Breast | DCIS | Endocrine and other factor-regulated calcium reabsorption | 12/846 | 53/8465 | 5.17e-03 | 2.69e-02 | 1.98e-02 | 12 |
hsa0414417 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0501624 | Cervix | HSIL_HPV | Huntington disease | 38/459 | 306/8465 | 1.21e-06 | 2.54e-05 | 2.05e-05 | 38 |
hsa0501634 | Cervix | HSIL_HPV | Huntington disease | 38/459 | 306/8465 | 1.21e-06 | 2.54e-05 | 2.05e-05 | 38 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa04961 | Colorectum | AD | Endocrine and other factor-regulated calcium reabsorption | 24/2092 | 53/8465 | 8.49e-04 | 5.93e-03 | 3.78e-03 | 24 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa049611 | Colorectum | AD | Endocrine and other factor-regulated calcium reabsorption | 24/2092 | 53/8465 | 8.49e-04 | 5.93e-03 | 3.78e-03 | 24 |
hsa050162 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AP2M1 | insertion | Frame_Shift_Ins | novel | c.338_339insG | p.Met114AspfsTer22 | p.M114Dfs*22 | protein_coding | TCGA-J2-8192-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |||
AP2M1 | SNV | Missense_Mutation | novel | c.369G>C | p.Glu123Asp | p.E123D | protein_coding | tolerated(0.07) | benign(0.077) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AP2M1 | SNV | Missense_Mutation | c.749N>G | p.Gln250Arg | p.Q250R | protein_coding | tolerated(0.34) | benign(0.003) | TCGA-BR-4191-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
AP2M1 | SNV | Missense_Mutation | c.313N>A | p.Glu105Lys | p.E105K | protein_coding | tolerated(0.1) | benign(0.122) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
AP2M1 | SNV | Missense_Mutation | c.1154G>A | p.Gly385Asp | p.G385D | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
AP2M1 | SNV | Missense_Mutation | novel | c.560N>A | p.Arg187Gln | p.R187Q | protein_coding | deleterious(0) | possibly_damaging(0.577) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
AP2M1 | SNV | Missense_Mutation | novel | c.1342N>A | p.Arg448Ser | p.R448S | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
AP2M1 | insertion | Frame_Shift_Ins | novel | c.746dupA | p.Gln250AlafsTer7 | p.Q250Afs*7 | protein_coding | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
AP2M1 | insertion | Frame_Shift_Ins | novel | c.990_991insCA | p.Val331GlnfsTer18 | p.V331Qfs*18 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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