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Gene: AOAH |
Gene summary for AOAH |
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Gene information | Species | Human | Gene symbol | AOAH | Gene ID | 313 |
Gene name | acyloxyacyl hydrolase | |
Gene Alias | AOAH | |
Cytomap | 7p14.2 | |
Gene Type | protein-coding | GO ID | GO:0000272 | UniProtAcc | A0A087WVT3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
313 | AOAH | HTA11_83_2000001011 | Human | Colorectum | SER | 1.24e-05 | 7.87e-01 | -0.1526 |
313 | AOAH | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.87e-06 | 6.06e-01 | -0.059 |
313 | AOAH | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.98e-15 | 1.02e+00 | 0.281 |
313 | AOAH | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.29e-25 | 8.99e-01 | 0.3859 |
313 | AOAH | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.47e-29 | 1.60e+00 | 0.2585 |
313 | AOAH | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.52e-18 | 6.26e-01 | 0.3005 |
313 | AOAH | CRC-1-8810 | Human | Colorectum | CRC | 5.52e-14 | 5.78e-01 | 0.6257 |
313 | AOAH | CRC-3-11773 | Human | Colorectum | CRC | 1.13e-25 | 9.06e-01 | 0.2564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016052 | Colorectum | AD | carbohydrate catabolic process | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
GO:00160421 | Colorectum | SER | lipid catabolic process | 77/2897 | 320/18723 | 3.52e-05 | 9.18e-04 | 77 |
GO:00442421 | Colorectum | SER | cellular lipid catabolic process | 51/2897 | 214/18723 | 8.60e-04 | 1.05e-02 | 51 |
GO:00160521 | Colorectum | SER | carbohydrate catabolic process | 38/2897 | 154/18723 | 1.92e-03 | 1.93e-02 | 38 |
GO:00066311 | Colorectum | SER | fatty acid metabolic process | 79/2897 | 390/18723 | 6.34e-03 | 4.56e-02 | 79 |
GO:00160522 | Colorectum | MSS | carbohydrate catabolic process | 45/3467 | 154/18723 | 7.93e-04 | 8.36e-03 | 45 |
GO:00066312 | Colorectum | MSS | fatty acid metabolic process | 95/3467 | 390/18723 | 2.20e-03 | 1.84e-02 | 95 |
GO:00160422 | Colorectum | MSS | lipid catabolic process | 77/3467 | 320/18723 | 7.43e-03 | 4.71e-02 | 77 |
GO:00160524 | Colorectum | CRC | carbohydrate catabolic process | 34/2078 | 154/18723 | 6.37e-05 | 1.39e-03 | 34 |
GO:00066314 | Colorectum | CRC | fatty acid metabolic process | 65/2078 | 390/18723 | 5.30e-04 | 7.42e-03 | 65 |
GO:00442622 | Colorectum | CRC | cellular carbohydrate metabolic process | 49/2078 | 283/18723 | 1.06e-03 | 1.24e-02 | 49 |
GO:00160424 | Colorectum | CRC | lipid catabolic process | 53/2078 | 320/18723 | 1.89e-03 | 1.93e-02 | 53 |
GO:00442423 | Colorectum | CRC | cellular lipid catabolic process | 37/2078 | 214/18723 | 4.16e-03 | 3.40e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AOAH | SNV | Missense_Mutation | c.938N>A | p.Gly313Glu | p.G313E | protein_coding | tolerated(0.05) | possibly_damaging(0.844) | TCGA-CC-5263-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
AOAH | SNV | Missense_Mutation | c.1360C>A | p.Leu454Ile | p.L454I | protein_coding | deleterious(0.05) | possibly_damaging(0.692) | TCGA-NI-A4U2-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
AOAH | SNV | Missense_Mutation | novel | c.1341N>C | p.Leu447Phe | p.L447F | protein_coding | tolerated(0.51) | benign(0.007) | TCGA-05-4398-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
AOAH | SNV | Missense_Mutation | c.842C>T | p.Ser281Phe | p.S281F | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-05-4417-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
AOAH | SNV | Missense_Mutation | c.1595N>T | p.Asn532Ile | p.N532I | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-05-5425-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | gefitinib | PD | ||
AOAH | SNV | Missense_Mutation | c.767N>A | p.Gly256Glu | p.G256E | protein_coding | deleterious(0.01) | possibly_damaging(0.781) | TCGA-49-4486-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
AOAH | SNV | Missense_Mutation | c.706N>T | p.Val236Phe | p.V236F | protein_coding | deleterious(0.02) | possibly_damaging(0.568) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | ||
AOAH | SNV | Missense_Mutation | novel | c.1885N>T | p.Gly629Cys | p.G629C | protein_coding | probably_damaging(0.985) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
AOAH | SNV | Missense_Mutation | c.112N>T | p.Gly38Trp | p.G38W | protein_coding | deleterious(0) | possibly_damaging(0.875) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | ||
AOAH | SNV | Missense_Mutation | c.98N>A | p.Pro33His | p.P33H | protein_coding | deleterious(0.03) | possibly_damaging(0.693) | TCGA-67-6217-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
313 | AOAH | ENZYME, DRUGGABLE GENOME | inhibitor | 252166807 |
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