![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ANXA11 |
Gene summary for ANXA11 |
![]() |
Gene information | Species | Human | Gene symbol | ANXA11 | Gene ID | 311 |
Gene name | annexin A11 | |
Gene Alias | ALS23 | |
Cytomap | 10q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | P50995 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
311 | ANXA11 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.00e-12 | 4.96e-01 | 0.0155 |
311 | ANXA11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.94e-31 | 1.48e+00 | -0.1808 |
311 | ANXA11 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.95e-24 | 1.09e+00 | -0.0811 |
311 | ANXA11 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.41e-18 | 8.73e-01 | -0.1088 |
311 | ANXA11 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.64e-40 | 1.13e+00 | -0.1954 |
311 | ANXA11 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.32e-14 | 2.08e+00 | -0.2602 |
311 | ANXA11 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.71e-15 | 1.49e+00 | -0.2196 |
311 | ANXA11 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.71e-16 | 9.83e-01 | -0.1207 |
311 | ANXA11 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.89e-21 | 1.10e+00 | -0.1526 |
311 | ANXA11 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.86e-40 | 1.27e+00 | -0.1464 |
311 | ANXA11 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.82e-24 | 8.32e-01 | -0.1001 |
311 | ANXA11 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.42e-30 | 1.45e+00 | -0.059 |
311 | ANXA11 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.81e-13 | 1.57e+00 | -0.1706 |
311 | ANXA11 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.14e-23 | 1.38e+00 | -0.2061 |
311 | ANXA11 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.01e-09 | 1.08e+00 | -0.1462 |
311 | ANXA11 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.56e-10 | 9.06e-01 | -0.0842 |
311 | ANXA11 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.00e-04 | 5.97e-01 | -0.0179 |
311 | ANXA11 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.28e-22 | 9.50e-01 | 0.096 |
311 | ANXA11 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.55e-08 | 9.82e-01 | 0.0446 |
311 | ANXA11 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.85e-08 | 8.41e-01 | 0.0528 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000910 | Colorectum | AD | cytokinesis | 59/3918 | 173/18723 | 3.74e-05 | 6.75e-04 | 59 |
GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
GO:0032506 | Colorectum | AD | cytokinetic process | 16/3918 | 39/18723 | 3.47e-03 | 2.51e-02 | 16 |
GO:00100381 | Colorectum | SER | response to metal ion | 84/2897 | 373/18723 | 1.87e-04 | 3.44e-03 | 84 |
GO:00009101 | Colorectum | SER | cytokinesis | 45/2897 | 173/18723 | 2.28e-04 | 3.93e-03 | 45 |
GO:00325061 | Colorectum | SER | cytokinetic process | 15/2897 | 39/18723 | 4.16e-04 | 6.17e-03 | 15 |
GO:00009102 | Colorectum | MSS | cytokinesis | 49/3467 | 173/18723 | 1.02e-03 | 1.02e-02 | 49 |
GO:00100382 | Colorectum | MSS | response to metal ion | 90/3467 | 373/18723 | 3.76e-03 | 2.76e-02 | 90 |
GO:00325062 | Colorectum | MSS | cytokinetic process | 14/3467 | 39/18723 | 7.79e-03 | 4.84e-02 | 14 |
GO:00100383 | Colorectum | MSI-H | response to metal ion | 41/1319 | 373/18723 | 3.09e-03 | 3.87e-02 | 41 |
GO:0051592 | Colorectum | FAP | response to calcium ion | 33/2622 | 149/18723 | 4.52e-03 | 3.08e-02 | 33 |
GO:00009103 | Colorectum | FAP | cytokinesis | 37/2622 | 173/18723 | 5.10e-03 | 3.37e-02 | 37 |
GO:00100384 | Colorectum | FAP | response to metal ion | 70/2622 | 373/18723 | 5.95e-03 | 3.75e-02 | 70 |
GO:00009104 | Colorectum | CRC | cytokinesis | 34/2078 | 173/18723 | 6.47e-04 | 8.55e-03 | 34 |
GO:00009108 | Endometrium | AEH | cytokinesis | 40/2100 | 173/18723 | 6.01e-06 | 1.49e-04 | 40 |
GO:001003816 | Endometrium | AEH | response to metal ion | 65/2100 | 373/18723 | 2.02e-04 | 2.54e-03 | 65 |
GO:00515927 | Endometrium | AEH | response to calcium ion | 28/2100 | 149/18723 | 4.22e-03 | 2.79e-02 | 28 |
GO:000091013 | Endometrium | EEC | cytokinesis | 40/2168 | 173/18723 | 1.29e-05 | 2.60e-04 | 40 |
GO:001003817 | Endometrium | EEC | response to metal ion | 66/2168 | 373/18723 | 2.86e-04 | 3.23e-03 | 66 |
GO:005159215 | Endometrium | EEC | response to calcium ion | 28/2168 | 149/18723 | 6.52e-03 | 3.81e-02 | 28 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050142 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa050143 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa050144 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050145 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050146 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa050147 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa050148 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa050149 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa0501420 | Endometrium | AEH | Amyotrophic lateral sclerosis | 123/1197 | 364/8465 | 2.17e-22 | 7.82e-21 | 5.72e-21 | 123 |
hsa05014110 | Endometrium | AEH | Amyotrophic lateral sclerosis | 123/1197 | 364/8465 | 2.17e-22 | 7.82e-21 | 5.72e-21 | 123 |
hsa0501425 | Endometrium | EEC | Amyotrophic lateral sclerosis | 128/1237 | 364/8465 | 9.83e-24 | 4.04e-22 | 3.01e-22 | 128 |
hsa0501435 | Endometrium | EEC | Amyotrophic lateral sclerosis | 128/1237 | 364/8465 | 9.83e-24 | 4.04e-22 | 3.01e-22 | 128 |
hsa0501430 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa05014113 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ANXA11 | FIB | Prostate | BPH | ACTB,CXCL16,KRT7, etc. | 1.16e-02 | ![]() |
ANXA11 | MSC | Prostate | BPH | ACTB,CXCL16,KRT7, etc. | 3.40e-03 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANXA11 | SNV | Missense_Mutation | c.1402N>T | p.Asp468Tyr | p.D468Y | P50995 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EJ-8474-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |
ANXA11 | SNV | Missense_Mutation | rs768664021 | c.628N>T | p.Arg210Trp | p.R210W | P50995 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ANXA11 | SNV | Missense_Mutation | c.1505N>A | p.Gly502Asp | p.G502D | P50995 | protein_coding | deleterious(0) | possibly_damaging(0.775) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | |
ANXA11 | SNV | Missense_Mutation | novel | c.839A>C | p.Glu280Ala | p.E280A | P50995 | protein_coding | tolerated(0.05) | probably_damaging(0.972) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ANXA11 | SNV | Missense_Mutation | novel | c.901T>A | p.Ser301Thr | p.S301T | P50995 | protein_coding | tolerated(0.86) | probably_damaging(0.998) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |