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Gene: ANO10 |
Gene summary for ANO10 |
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Gene information | Species | Human | Gene symbol | ANO10 | Gene ID | 55129 |
Gene name | anoctamin 10 | |
Gene Alias | SCAR10 | |
Cytomap | 3p22.1-p21.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NW15 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55129 | ANO10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.08e-18 | -4.92e-01 | 0.0155 |
55129 | ANO10 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.63e-06 | 4.64e-01 | -0.1954 |
55129 | ANO10 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.99e-13 | -6.50e-01 | 0.096 |
55129 | ANO10 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.57e-03 | -6.17e-01 | 0.0528 |
55129 | ANO10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.97e-11 | -4.57e-01 | 0.0674 |
55129 | ANO10 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.10e-20 | -6.56e-01 | 0.294 |
55129 | ANO10 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.36e-07 | -4.08e-01 | 0.3859 |
55129 | ANO10 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.63e-07 | -7.11e-01 | 0.2585 |
55129 | ANO10 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.40e-30 | -7.38e-01 | 0.3005 |
55129 | ANO10 | F007 | Human | Colorectum | FAP | 2.66e-02 | -3.52e-01 | 0.1176 |
55129 | ANO10 | A001-C-207 | Human | Colorectum | FAP | 2.11e-07 | -4.95e-01 | 0.1278 |
55129 | ANO10 | A015-C-203 | Human | Colorectum | FAP | 2.55e-38 | -6.13e-01 | -0.1294 |
55129 | ANO10 | A015-C-204 | Human | Colorectum | FAP | 2.10e-05 | -3.53e-01 | -0.0228 |
55129 | ANO10 | A014-C-040 | Human | Colorectum | FAP | 2.78e-07 | -6.56e-01 | -0.1184 |
55129 | ANO10 | A002-C-201 | Human | Colorectum | FAP | 1.75e-21 | -6.04e-01 | 0.0324 |
55129 | ANO10 | A002-C-203 | Human | Colorectum | FAP | 2.18e-02 | -2.80e-01 | 0.2786 |
55129 | ANO10 | A001-C-119 | Human | Colorectum | FAP | 2.77e-17 | -8.02e-01 | -0.1557 |
55129 | ANO10 | A001-C-108 | Human | Colorectum | FAP | 2.52e-27 | -5.91e-01 | -0.0272 |
55129 | ANO10 | A002-C-205 | Human | Colorectum | FAP | 5.76e-31 | -7.47e-01 | -0.1236 |
55129 | ANO10 | A001-C-104 | Human | Colorectum | FAP | 3.25e-09 | -4.49e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:00156981 | Colorectum | FAP | inorganic anion transport | 38/2622 | 180/18723 | 5.73e-03 | 3.67e-02 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANO10 | deletion | Frame_Shift_Del | rs775536114 | c.269_270delNN | p.Lys90ArgfsTer4 | p.K90Rfs*4 | Q9NW15 | protein_coding | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ANO10 | insertion | Frame_Shift_Ins | novel | c.1458_1459insA | p.Glu487ArgfsTer10 | p.E487Rfs*10 | Q9NW15 | protein_coding | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ANO10 | SNV | Missense_Mutation | rs369752949 | c.1378N>A | p.Gly460Ser | p.G460S | Q9NW15 | protein_coding | tolerated(0.91) | benign(0) | TCGA-BC-A10S-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ANO10 | SNV | Missense_Mutation | c.999G>A | p.Met333Ile | p.M333I | Q9NW15 | protein_coding | deleterious(0.04) | probably_damaging(0.983) | TCGA-BC-A5W4-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ANO10 | SNV | Missense_Mutation | c.1865N>A | p.Met622Lys | p.M622K | Q9NW15 | protein_coding | tolerated(0.67) | benign(0.003) | TCGA-44-3398-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANO10 | SNV | Missense_Mutation | novel | c.1801N>T | p.Ala601Ser | p.A601S | Q9NW15 | protein_coding | deleterious(0.03) | benign(0.119) | TCGA-50-5045-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ANO10 | SNV | Missense_Mutation | rs372086237 | c.1628N>A | p.Arg543His | p.R543H | Q9NW15 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-50-5939-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ANO10 | SNV | Missense_Mutation | c.1310N>G | p.Leu437Arg | p.L437R | Q9NW15 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ANO10 | SNV | Missense_Mutation | novel | c.1052N>T | p.Gly351Val | p.G351V | Q9NW15 | protein_coding | tolerated(0.22) | benign(0.088) | TCGA-39-5034-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ANO10 | SNV | Missense_Mutation | c.134N>T | p.Asp45Val | p.D45V | Q9NW15 | protein_coding | deleterious(0.05) | benign(0.099) | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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