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Gene: ANKS1A |
Gene summary for ANKS1A |
Gene summary. |
Gene information | Species | Human | Gene symbol | ANKS1A | Gene ID | 23294 |
Gene name | ankyrin repeat and sterile alpha motif domain containing 1A | |
Gene Alias | ANKS1 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q05CP0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23294 | ANKS1A | CCI_1 | Human | Cervix | CC | 2.89e-06 | 8.34e-01 | 0.528 |
23294 | ANKS1A | CCI_2 | Human | Cervix | CC | 7.99e-15 | 1.26e+00 | 0.5249 |
23294 | ANKS1A | CCI_3 | Human | Cervix | CC | 1.89e-18 | 1.03e+00 | 0.516 |
23294 | ANKS1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.43e-14 | -5.34e-01 | 0.0155 |
23294 | ANKS1A | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.51e-02 | -3.38e-01 | -0.1808 |
23294 | ANKS1A | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.59e-02 | -6.84e-01 | 0.0216 |
23294 | ANKS1A | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.71e-03 | -3.34e-01 | -0.0811 |
23294 | ANKS1A | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.50e-03 | -3.77e-01 | -0.1207 |
23294 | ANKS1A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.53e-02 | -3.70e-01 | 0.096 |
23294 | ANKS1A | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.92e-02 | -5.99e-01 | 0.0528 |
23294 | ANKS1A | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.36e-03 | -3.76e-01 | 0.0338 |
23294 | ANKS1A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.44e-06 | -4.31e-01 | 0.294 |
23294 | ANKS1A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.68e-12 | -5.24e-01 | 0.3005 |
23294 | ANKS1A | A002-C-010 | Human | Colorectum | FAP | 3.20e-04 | -2.22e-01 | 0.242 |
23294 | ANKS1A | A001-C-207 | Human | Colorectum | FAP | 2.28e-03 | -2.56e-01 | 0.1278 |
23294 | ANKS1A | A015-C-203 | Human | Colorectum | FAP | 5.06e-39 | -6.15e-01 | -0.1294 |
23294 | ANKS1A | A015-C-204 | Human | Colorectum | FAP | 6.75e-15 | -5.21e-01 | -0.0228 |
23294 | ANKS1A | A014-C-040 | Human | Colorectum | FAP | 8.70e-10 | -7.13e-01 | -0.1184 |
23294 | ANKS1A | A002-C-201 | Human | Colorectum | FAP | 6.57e-19 | -5.07e-01 | 0.0324 |
23294 | ANKS1A | A002-C-203 | Human | Colorectum | FAP | 3.35e-06 | -2.67e-01 | 0.2786 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069292 | Cervix | CC | substrate-dependent cell migration | 9/2311 | 23/18723 | 1.05e-03 | 8.76e-03 | 9 |
GO:00480131 | Cervix | CC | ephrin receptor signaling pathway | 14/2311 | 51/18723 | 2.78e-03 | 1.87e-02 | 14 |
GO:0048013 | Colorectum | MSS | ephrin receptor signaling pathway | 17/3467 | 51/18723 | 8.28e-03 | 4.99e-02 | 17 |
GO:0021700 | Colorectum | FAP | developmental maturation | 57/2622 | 280/18723 | 2.08e-03 | 1.72e-02 | 57 |
GO:00217001 | Colorectum | CRC | developmental maturation | 47/2078 | 280/18723 | 2.52e-03 | 2.38e-02 | 47 |
GO:0006929 | Lung | IAC | substrate-dependent cell migration | 8/2061 | 23/18723 | 2.28e-03 | 2.22e-02 | 8 |
GO:00069291 | Lung | AIS | substrate-dependent cell migration | 9/1849 | 23/18723 | 1.98e-04 | 4.07e-03 | 9 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKS1A | SNV | Missense_Mutation | novel | c.337G>T | p.Gly113Cys | p.G113C | Q92625 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ANKS1A | SNV | Missense_Mutation | c.1048N>T | p.Asp350Tyr | p.D350Y | Q92625 | protein_coding | deleterious(0) | benign(0.34) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKS1A | SNV | Missense_Mutation | rs144409160 | c.1930C>T | p.Arg644Trp | p.R644W | Q92625 | protein_coding | tolerated(0.24) | probably_damaging(0.993) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | c.2816C>T | p.Ser939Phe | p.S939F | Q92625 | protein_coding | deleterious(0.03) | probably_damaging(0.952) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKS1A | SNV | Missense_Mutation | novel | c.1547N>A | p.Pro516His | p.P516H | Q92625 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ANKS1A | SNV | Missense_Mutation | rs541932194 | c.2605N>T | p.Arg869Trp | p.R869W | Q92625 | protein_coding | tolerated(0.06) | possibly_damaging(0.781) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ANKS1A | SNV | Missense_Mutation | novel | c.3085N>A | p.Leu1029Met | p.L1029M | Q92625 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | novel | c.772N>A | p.Gly258Ser | p.G258S | Q92625 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A3G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | novel | c.2825A>G | p.Tyr942Cys | p.Y942C | Q92625 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | novel | c.1074G>T | p.Glu358Asp | p.E358D | Q92625 | protein_coding | tolerated(0.46) | probably_damaging(0.97) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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