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Gene: ANKRD52 |
Gene summary for ANKRD52 |
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Gene information | Species | Human | Gene symbol | ANKRD52 | Gene ID | 283373 |
Gene name | ankyrin repeat domain 52 | |
Gene Alias | ANKRD33 | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | B3KWN0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
283373 | ANKRD52 | LZE7T | Human | Esophagus | ESCC | 3.48e-07 | 3.36e-01 | 0.0667 |
283373 | ANKRD52 | LZE22T | Human | Esophagus | ESCC | 3.07e-03 | 2.88e-01 | 0.068 |
283373 | ANKRD52 | LZE24T | Human | Esophagus | ESCC | 1.36e-07 | 1.64e-01 | 0.0596 |
283373 | ANKRD52 | P1T-E | Human | Esophagus | ESCC | 5.33e-04 | 1.93e-01 | 0.0875 |
283373 | ANKRD52 | P2T-E | Human | Esophagus | ESCC | 2.85e-14 | 3.38e-01 | 0.1177 |
283373 | ANKRD52 | P4T-E | Human | Esophagus | ESCC | 7.13e-14 | 1.81e-01 | 0.1323 |
283373 | ANKRD52 | P5T-E | Human | Esophagus | ESCC | 1.39e-10 | 1.95e-01 | 0.1327 |
283373 | ANKRD52 | P8T-E | Human | Esophagus | ESCC | 1.66e-08 | 2.19e-01 | 0.0889 |
283373 | ANKRD52 | P9T-E | Human | Esophagus | ESCC | 1.08e-02 | 8.09e-02 | 0.1131 |
283373 | ANKRD52 | P10T-E | Human | Esophagus | ESCC | 1.21e-12 | 2.25e-01 | 0.116 |
283373 | ANKRD52 | P11T-E | Human | Esophagus | ESCC | 2.39e-03 | 2.18e-01 | 0.1426 |
283373 | ANKRD52 | P12T-E | Human | Esophagus | ESCC | 1.18e-10 | 2.00e-01 | 0.1122 |
283373 | ANKRD52 | P15T-E | Human | Esophagus | ESCC | 6.47e-10 | 1.94e-01 | 0.1149 |
283373 | ANKRD52 | P16T-E | Human | Esophagus | ESCC | 6.27e-08 | 1.61e-01 | 0.1153 |
283373 | ANKRD52 | P17T-E | Human | Esophagus | ESCC | 5.25e-06 | 2.37e-01 | 0.1278 |
283373 | ANKRD52 | P19T-E | Human | Esophagus | ESCC | 3.33e-07 | 4.15e-01 | 0.1662 |
283373 | ANKRD52 | P20T-E | Human | Esophagus | ESCC | 8.36e-17 | 2.02e-01 | 0.1124 |
283373 | ANKRD52 | P21T-E | Human | Esophagus | ESCC | 1.32e-05 | 1.59e-01 | 0.1617 |
283373 | ANKRD52 | P22T-E | Human | Esophagus | ESCC | 4.55e-08 | 1.38e-01 | 0.1236 |
283373 | ANKRD52 | P23T-E | Human | Esophagus | ESCC | 2.52e-11 | 2.29e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD52 | SNV | Missense_Mutation | c.3134C>T | p.Thr1045Met | p.T1045M | Q8NB46 | protein_coding | deleterious(0.02) | benign(0.063) | TCGA-BG-A0MQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKRD52 | SNV | Missense_Mutation | c.615N>T | p.Lys205Asn | p.K205N | Q8NB46 | protein_coding | tolerated(0.05) | benign(0.139) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD52 | SNV | Missense_Mutation | c.2830A>C | p.Ile944Leu | p.I944L | Q8NB46 | protein_coding | tolerated(0.41) | benign(0.024) | TCGA-D1-A161-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKRD52 | SNV | Missense_Mutation | c.341N>A | p.Ala114Asp | p.A114D | Q8NB46 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D1-A17B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKRD52 | SNV | Missense_Mutation | rs780759590 | c.2450N>T | p.Ser817Leu | p.S817L | Q8NB46 | protein_coding | tolerated(0.28) | benign(0.009) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD52 | SNV | Missense_Mutation | novel | c.2870N>T | p.Thr957Ile | p.T957I | Q8NB46 | protein_coding | deleterious(0.02) | benign(0.091) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ANKRD52 | SNV | Missense_Mutation | novel | c.856N>A | p.Ala286Thr | p.A286T | Q8NB46 | protein_coding | deleterious(0.01) | possibly_damaging(0.833) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ANKRD52 | SNV | Missense_Mutation | novel | c.1243N>A | p.Asp415Asn | p.D415N | Q8NB46 | protein_coding | deleterious(0.02) | benign(0.395) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ANKRD52 | SNV | Missense_Mutation | novel | c.122G>T | p.Arg41Met | p.R41M | Q8NB46 | protein_coding | deleterious(0) | benign(0.439) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD52 | SNV | Missense_Mutation | rs766786981 | c.2656N>A | p.Ala886Thr | p.A886T | Q8NB46 | protein_coding | tolerated(0.2) | benign(0.045) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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