![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: AMDHD2 |
Gene summary for AMDHD2 |
![]() |
Gene information | Species | Human | Gene symbol | AMDHD2 | Gene ID | 51005 |
Gene name | amidohydrolase domain containing 2 | |
Gene Alias | CGI-14 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q9Y303 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51005 | AMDHD2 | C04 | Human | Oral cavity | OSCC | 5.16e-07 | 4.17e-01 | 0.2633 |
51005 | AMDHD2 | C21 | Human | Oral cavity | OSCC | 2.78e-33 | 8.36e-01 | 0.2678 |
51005 | AMDHD2 | C30 | Human | Oral cavity | OSCC | 3.05e-26 | 9.36e-01 | 0.3055 |
51005 | AMDHD2 | C38 | Human | Oral cavity | OSCC | 2.16e-03 | 5.00e-01 | 0.172 |
51005 | AMDHD2 | C46 | Human | Oral cavity | OSCC | 2.17e-06 | 2.37e-01 | 0.1673 |
51005 | AMDHD2 | C51 | Human | Oral cavity | OSCC | 2.18e-09 | 5.24e-01 | 0.2674 |
51005 | AMDHD2 | C06 | Human | Oral cavity | OSCC | 2.04e-02 | 5.07e-01 | 0.2699 |
51005 | AMDHD2 | C08 | Human | Oral cavity | OSCC | 1.73e-10 | 2.98e-01 | 0.1919 |
51005 | AMDHD2 | LN46 | Human | Oral cavity | OSCC | 1.45e-05 | 3.68e-01 | 0.1666 |
51005 | AMDHD2 | SYSMH2 | Human | Oral cavity | OSCC | 9.85e-06 | 2.89e-01 | 0.2326 |
51005 | AMDHD2 | SYSMH3 | Human | Oral cavity | OSCC | 8.32e-10 | 3.70e-01 | 0.2442 |
51005 | AMDHD2 | PTC01 | Human | Thyroid | PTC | 1.87e-04 | 9.18e-02 | 0.1899 |
51005 | AMDHD2 | PTC04 | Human | Thyroid | PTC | 7.38e-03 | 9.67e-02 | 0.1927 |
51005 | AMDHD2 | PTC05 | Human | Thyroid | PTC | 7.64e-08 | 2.41e-01 | 0.2065 |
51005 | AMDHD2 | PTC06 | Human | Thyroid | PTC | 3.55e-06 | 1.80e-01 | 0.2057 |
51005 | AMDHD2 | PTC07 | Human | Thyroid | PTC | 4.29e-10 | 2.05e-01 | 0.2044 |
51005 | AMDHD2 | ATC09 | Human | Thyroid | ATC | 1.31e-07 | 3.33e-01 | 0.2871 |
51005 | AMDHD2 | ATC12 | Human | Thyroid | ATC | 7.69e-25 | 5.23e-01 | 0.34 |
51005 | AMDHD2 | ATC1 | Human | Thyroid | ATC | 1.51e-06 | 3.46e-01 | 0.2878 |
51005 | AMDHD2 | ATC4 | Human | Thyroid | ATC | 1.37e-31 | 6.28e-01 | 0.34 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00092255 | Oral cavity | OSCC | nucleotide-sugar metabolic process | 26/7305 | 36/18723 | 5.44e-05 | 4.51e-04 | 26 |
GO:19011361 | Oral cavity | OSCC | carbohydrate derivative catabolic process | 89/7305 | 172/18723 | 4.52e-04 | 2.73e-03 | 89 |
GO:00442826 | Oral cavity | OSCC | small molecule catabolic process | 174/7305 | 376/18723 | 2.25e-03 | 1.00e-02 | 174 |
GO:00092261 | Oral cavity | OSCC | nucleotide-sugar biosynthetic process | 14/7305 | 19/18723 | 2.31e-03 | 1.02e-02 | 14 |
GO:0006040 | Oral cavity | OSCC | amino sugar metabolic process | 24/7305 | 42/18723 | 1.30e-02 | 4.34e-02 | 24 |
GO:0006047 | Oral cavity | OSCC | UDP-N-acetylglucosamine metabolic process | 10/7305 | 14/18723 | 1.44e-02 | 4.69e-02 | 10 |
GO:0046348 | Oral cavity | OSCC | amino sugar catabolic process | 10/7305 | 14/18723 | 1.44e-02 | 4.69e-02 | 10 |
GO:00092257 | Thyroid | PTC | nucleotide-sugar metabolic process | 23/5968 | 36/18723 | 7.78e-05 | 6.66e-04 | 23 |
GO:00060472 | Thyroid | PTC | UDP-N-acetylglucosamine metabolic process | 9/5968 | 14/18723 | 1.27e-02 | 4.92e-02 | 9 |
GO:000922511 | Thyroid | ATC | nucleotide-sugar metabolic process | 24/6293 | 36/18723 | 5.10e-05 | 3.99e-04 | 24 |
GO:00060471 | Thyroid | ATC | UDP-N-acetylglucosamine metabolic process | 10/6293 | 14/18723 | 4.31e-03 | 1.80e-02 | 10 |
GO:00092263 | Thyroid | ATC | nucleotide-sugar biosynthetic process | 12/6293 | 19/18723 | 7.97e-03 | 3.08e-02 | 12 |
GO:19011363 | Thyroid | ATC | carbohydrate derivative catabolic process | 73/6293 | 172/18723 | 9.43e-03 | 3.47e-02 | 73 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AMDHD2 | SNV | Missense_Mutation | novel | c.532N>G | p.Leu178Val | p.L178V | Q9Y303 | protein_coding | tolerated(0.06) | probably_damaging(0.971) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
AMDHD2 | SNV | Missense_Mutation | novel | c.229N>A | p.Gly77Ser | p.G77S | Q9Y303 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-94-A4VJ-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AMDHD2 | SNV | Missense_Mutation | novel | c.664G>T | p.Ala222Ser | p.A222S | Q9Y303 | protein_coding | deleterious(0.02) | probably_damaging(0.95) | TCGA-CQ-5333-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AMDHD2 | SNV | Missense_Mutation | rs770281026 | c.650N>A | p.Arg217Gln | p.R217Q | Q9Y303 | protein_coding | tolerated(0.18) | benign(0.041) | TCGA-CQ-A4CI-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
AMDHD2 | SNV | Missense_Mutation | c.836N>C | p.Arg279Pro | p.R279P | Q9Y303 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
AMDHD2 | SNV | Missense_Mutation | c.101N>T | p.Arg34Leu | p.R34L | Q9Y303 | protein_coding | deleterious(0.03) | possibly_damaging(0.748) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AMDHD2 | SNV | Missense_Mutation | rs779695777 | c.445C>T | p.Arg149Trp | p.R149W | Q9Y303 | protein_coding | tolerated(0.08) | probably_damaging(0.949) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
AMDHD2 | SNV | Missense_Mutation | c.460N>A | p.Ala154Thr | p.A154T | Q9Y303 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AMDHD2 | SNV | Missense_Mutation | novel | c.1436N>A | p.Arg479Lys | p.R479K | Q9Y303 | protein_coding | tolerated_low_confidence(0.33) | benign(0.005) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
AMDHD2 | SNV | Missense_Mutation | c.1409C>T | p.Thr470Ile | p.T470I | Q9Y303 | protein_coding | deleterious_low_confidence(0.01) | benign(0.009) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |