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Gene: AKAP12 |
Gene summary for AKAP12 |
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Gene information | Species | Human | Gene symbol | AKAP12 | Gene ID | 9590 |
Gene name | A-kinase anchoring protein 12 | |
Gene Alias | AKAP250 | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q02952 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9590 | AKAP12 | AEH-subject2 | Human | Endometrium | AEH | 1.15e-02 | 2.86e-02 | -0.2525 |
9590 | AKAP12 | AEH-subject3 | Human | Endometrium | AEH | 3.27e-05 | -1.46e-01 | -0.2576 |
9590 | AKAP12 | AEH-subject4 | Human | Endometrium | AEH | 2.27e-02 | 7.66e-02 | -0.2657 |
9590 | AKAP12 | AEH-subject5 | Human | Endometrium | AEH | 1.70e-03 | -1.33e-01 | -0.2953 |
9590 | AKAP12 | EEC-subject1 | Human | Endometrium | EEC | 4.33e-04 | -1.40e-01 | -0.2682 |
9590 | AKAP12 | EEC-subject2 | Human | Endometrium | EEC | 1.46e-05 | -3.60e-02 | -0.2607 |
9590 | AKAP12 | EEC-subject3 | Human | Endometrium | EEC | 1.67e-04 | -1.29e-01 | -0.2525 |
9590 | AKAP12 | EEC-subject4 | Human | Endometrium | EEC | 6.35e-05 | -1.50e-01 | -0.2571 |
9590 | AKAP12 | EEC-subject5 | Human | Endometrium | EEC | 2.27e-06 | -1.72e-01 | -0.249 |
9590 | AKAP12 | GSM5276934 | Human | Endometrium | EEC | 3.90e-37 | 8.73e-01 | -0.0913 |
9590 | AKAP12 | GSM5276937 | Human | Endometrium | EEC | 4.24e-57 | 1.31e+00 | -0.0897 |
9590 | AKAP12 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.49e-06 | -1.48e-01 | -0.1869 |
9590 | AKAP12 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.13e-05 | -2.03e-01 | -0.1875 |
9590 | AKAP12 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.12e-06 | -2.03e-01 | -0.1883 |
9590 | AKAP12 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.85e-09 | -1.96e-01 | -0.1934 |
9590 | AKAP12 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.65e-11 | -1.60e-01 | -0.1917 |
9590 | AKAP12 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 9.79e-09 | -1.65e-01 | -0.1916 |
9590 | AKAP12 | P4T-E | Human | Esophagus | ESCC | 8.68e-10 | 3.56e-01 | 0.1323 |
9590 | AKAP12 | P8T-E | Human | Esophagus | ESCC | 4.67e-07 | 3.46e-01 | 0.0889 |
9590 | AKAP12 | P11T-E | Human | Esophagus | ESCC | 1.86e-10 | 9.50e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000166710 | Endometrium | AEH | ameboidal-type cell migration | 90/2100 | 475/18723 | 3.73e-07 | 1.57e-05 | 90 |
GO:00434105 | Endometrium | AEH | positive regulation of MAPK cascade | 84/2100 | 480/18723 | 2.19e-05 | 4.25e-04 | 84 |
GO:000223710 | Endometrium | AEH | response to molecule of bacterial origin | 65/2100 | 363/18723 | 9.00e-05 | 1.30e-03 | 65 |
GO:003249610 | Endometrium | AEH | response to lipopolysaccharide | 62/2100 | 343/18723 | 9.82e-05 | 1.41e-03 | 62 |
GO:00107616 | Endometrium | AEH | fibroblast migration | 14/2100 | 47/18723 | 4.51e-04 | 4.76e-03 | 14 |
GO:007135610 | Endometrium | AEH | cellular response to tumor necrosis factor | 41/2100 | 229/18723 | 1.66e-03 | 1.36e-02 | 41 |
GO:003461210 | Endometrium | AEH | response to tumor necrosis factor | 44/2100 | 253/18723 | 2.08e-03 | 1.61e-02 | 44 |
GO:00018198 | Endometrium | AEH | positive regulation of cytokine production | 71/2100 | 467/18723 | 4.76e-03 | 3.02e-02 | 71 |
GO:00705555 | Endometrium | AEH | response to interleukin-1 | 26/2100 | 143/18723 | 8.78e-03 | 4.78e-02 | 26 |
GO:000166716 | Endometrium | EEC | ameboidal-type cell migration | 91/2168 | 475/18723 | 7.87e-07 | 2.80e-05 | 91 |
GO:004341011 | Endometrium | EEC | positive regulation of MAPK cascade | 89/2168 | 480/18723 | 4.21e-06 | 1.08e-04 | 89 |
GO:000223714 | Endometrium | EEC | response to molecule of bacterial origin | 68/2168 | 363/18723 | 3.96e-05 | 6.64e-04 | 68 |
GO:003249614 | Endometrium | EEC | response to lipopolysaccharide | 65/2168 | 343/18723 | 4.04e-05 | 6.75e-04 | 65 |
GO:007135615 | Endometrium | EEC | cellular response to tumor necrosis factor | 45/2168 | 229/18723 | 2.54e-04 | 2.94e-03 | 45 |
GO:003461215 | Endometrium | EEC | response to tumor necrosis factor | 48/2168 | 253/18723 | 3.77e-04 | 4.03e-03 | 48 |
GO:001076112 | Endometrium | EEC | fibroblast migration | 14/2168 | 47/18723 | 6.25e-04 | 6.14e-03 | 14 |
GO:000181913 | Endometrium | EEC | positive regulation of cytokine production | 73/2168 | 467/18723 | 4.64e-03 | 2.97e-02 | 73 |
GO:007055511 | Endometrium | EEC | response to interleukin-1 | 27/2168 | 143/18723 | 6.99e-03 | 4.01e-02 | 27 |
GO:0051767 | Endometrium | EEC | nitric-oxide synthase biosynthetic process | 7/2168 | 21/18723 | 7.38e-03 | 4.15e-02 | 7 |
GO:0051769 | Endometrium | EEC | regulation of nitric-oxide synthase biosynthetic process | 7/2168 | 21/18723 | 7.38e-03 | 4.15e-02 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKAP12 | SNV | Missense_Mutation | c.5034T>A | p.Asp1678Glu | p.D1678E | Q02952 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
AKAP12 | SNV | Missense_Mutation | novel | c.1524N>T | p.Arg508Ser | p.R508S | Q02952 | protein_coding | deleterious(0) | possibly_damaging(0.738) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
AKAP12 | SNV | Missense_Mutation | c.529N>G | p.Lys177Glu | p.K177E | Q02952 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
AKAP12 | SNV | Missense_Mutation | rs752036291 | c.2072N>T | p.Arg691Ile | p.R691I | Q02952 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
AKAP12 | SNV | Missense_Mutation | rs769926929 | c.1054N>A | p.Ala352Thr | p.A352T | Q02952 | protein_coding | tolerated(0.14) | benign(0) | TCGA-D5-6541-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AKAP12 | SNV | Missense_Mutation | c.4331N>G | p.Leu1444Trp | p.L1444W | Q02952 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-DM-A28K-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AKAP12 | SNV | Missense_Mutation | rs764470310 | c.862N>A | p.Val288Met | p.V288M | Q02952 | protein_coding | tolerated(0.05) | possibly_damaging(0.563) | TCGA-DM-A28M-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AKAP12 | SNV | Missense_Mutation | c.2789N>A | p.Ala930Glu | p.A930E | Q02952 | protein_coding | tolerated(0.79) | benign(0) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
AKAP12 | SNV | Missense_Mutation | c.2494N>A | p.Gly832Arg | p.G832R | Q02952 | protein_coding | tolerated(0.12) | probably_damaging(0.97) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AKAP12 | SNV | Missense_Mutation | rs140014031 | c.2896G>A | p.Val966Ile | p.V966I | Q02952 | protein_coding | tolerated(0.49) | benign(0.001) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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