Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: AHI1

Gene summary for AHI1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

AHI1

Gene ID

54806

Gene nameAbelson helper integration site 1
Gene AliasAHI-1
Cytomap6q23.3
Gene Typeprotein-coding
GO ID

GO:0001654

UniProtAcc

Q8N157


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
54806AHI1HTA11_3410_2000001011HumanColorectumAD3.65e-23-7.48e-010.0155
54806AHI1HTA11_2487_2000001011HumanColorectumSER1.66e-12-6.85e-01-0.1808
54806AHI1HTA11_2951_2000001011HumanColorectumAD1.89e-03-8.20e-010.0216
54806AHI1HTA11_1938_2000001011HumanColorectumAD4.35e-02-4.44e-01-0.0811
54806AHI1HTA11_3361_2000001011HumanColorectumAD1.40e-09-7.60e-01-0.1207
54806AHI1HTA11_83_2000001011HumanColorectumSER1.36e-03-5.68e-01-0.1526
54806AHI1HTA11_696_2000001011HumanColorectumAD1.33e-13-4.78e-01-0.1464
54806AHI1HTA11_866_2000001011HumanColorectumAD1.62e-15-4.86e-01-0.1001
54806AHI1HTA11_5212_2000001011HumanColorectumAD1.21e-03-6.93e-01-0.2061
54806AHI1HTA11_7862_2000001011HumanColorectumAD1.96e-03-5.80e-01-0.0179
54806AHI1HTA11_866_3004761011HumanColorectumAD1.58e-13-6.06e-010.096
54806AHI1HTA11_8622_2000001021HumanColorectumSER2.87e-02-5.86e-010.0528
54806AHI1HTA11_10711_2000001011HumanColorectumAD4.33e-09-6.67e-010.0338
54806AHI1HTA11_7696_3000711011HumanColorectumAD3.57e-10-3.80e-010.0674
54806AHI1HTA11_6818_2000001011HumanColorectumAD1.21e-02-6.08e-010.0112
54806AHI1HTA11_6818_2000001021HumanColorectumAD1.29e-03-5.33e-010.0588
54806AHI1HTA11_99999970781_79442HumanColorectumMSS4.10e-14-4.14e-010.294
54806AHI1HTA11_99999971662_82457HumanColorectumMSS3.04e-04-3.10e-010.3859
54806AHI1HTA11_99999973899_84307HumanColorectumMSS1.57e-04-6.30e-010.2585
54806AHI1HTA11_99999974143_84620HumanColorectumMSS3.86e-22-6.01e-010.3005
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0043112ColorectumADreceptor metabolic process62/3918166/187238.18e-072.85e-0562
GO:0006898ColorectumADreceptor-mediated endocytosis76/3918244/187231.07e-041.59e-0376
GO:0030100ColorectumADregulation of endocytosis67/3918211/187231.42e-042.01e-0367
GO:0060562ColorectumADepithelial tube morphogenesis93/3918325/187235.65e-046.00e-0393
GO:0045807ColorectumADpositive regulation of endocytosis35/3918100/187237.78e-047.78e-0335
GO:0048260ColorectumADpositive regulation of receptor-mediated endocytosis20/391852/187232.87e-032.14e-0220
GO:0072073ColorectumADkidney epithelium development42/3918136/187234.02e-032.80e-0242
GO:0001738ColorectumADmorphogenesis of a polarized epithelium31/391894/187234.30e-032.95e-0231
GO:0048568ColorectumADembryonic organ development112/3918427/187234.60e-033.14e-02112
GO:0048259ColorectumADregulation of receptor-mediated endocytosis35/3918110/187234.85e-033.27e-0235
GO:0030859ColorectumADpolarized epithelial cell differentiation11/391824/187235.43e-033.55e-0211
GO:0031623ColorectumADreceptor internalization35/3918113/187237.72e-034.66e-0235
GO:00301001ColorectumSERregulation of endocytosis48/2897211/187233.29e-032.82e-0248
GO:00431121ColorectumMSSreceptor metabolic process57/3467166/187238.47e-072.97e-0557
GO:00301002ColorectumMSSregulation of endocytosis63/3467211/187234.05e-057.66e-0463
GO:00605621ColorectumMSSepithelial tube morphogenesis88/3467325/187238.45e-051.37e-0388
GO:00068981ColorectumMSSreceptor-mediated endocytosis69/3467244/187231.18e-041.82e-0369
GO:00458071ColorectumMSSpositive regulation of endocytosis33/3467100/187233.73e-044.72e-0333
GO:00482601ColorectumMSSpositive regulation of receptor-mediated endocytosis19/346752/187231.66e-031.49e-0219
GO:00482591ColorectumMSSregulation of receptor-mediated endocytosis33/3467110/187232.33e-031.90e-0233
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
AHI1SNVMissense_Mutationc.3221G>Ap.Arg1074Hisp.R1074HQ8N157protein_codingdeleterious(0)probably_damaging(0.997)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
AHI1SNVMissense_Mutationrs371242173c.3236N>Ap.Arg1079Glnp.R1079QQ8N157protein_codingtolerated(0.99)benign(0.035)TCGA-AP-A05O-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIChemotherapycarboplatinPD
AHI1SNVMissense_Mutationrs551136002c.455N>Ap.Ser152Tyrp.S152YQ8N157protein_codingtolerated(0.16)benign(0.01)TCGA-AP-A0LM-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinSD
AHI1SNVMissense_Mutationnovelc.3317N>Cp.Val1106Alap.V1106AQ8N157protein_codingdeleterious(0)probably_damaging(0.991)TCGA-AP-A1DK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
AHI1SNVMissense_Mutationnovelc.1090N>Tp.Pro364Serp.P364SQ8N157protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AP-A1DK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
AHI1SNVMissense_Mutationrs371242173c.3236N>Ap.Arg1079Glnp.R1079QQ8N157protein_codingtolerated(0.99)benign(0.035)TCGA-AX-A06D-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVChemotherapycarboplatinPD
AHI1SNVMissense_Mutationnovelc.1873G>Ap.Ala625Thrp.A625TQ8N157protein_codingdeleterious(0)probably_damaging(0.983)TCGA-AX-A0J1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
AHI1SNVMissense_Mutationnovelc.965N>Ap.Gly322Aspp.G322DQ8N157protein_codingtolerated(0.06)benign(0.067)TCGA-AX-A1CE-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnspecificPaclitaxelSD
AHI1SNVMissense_Mutationnovelc.143N>Tp.Thr48Ilep.T48IQ8N157protein_codingtolerated(0.15)benign(0)TCGA-AX-A1CE-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnspecificPaclitaxelSD
AHI1SNVMissense_Mutationc.3408N>Tp.Lys1136Asnp.K1136NQ8N157protein_codingtolerated(0.07)probably_damaging(0.997)TCGA-B5-A0JY-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapydoxorubicinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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