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Gene: DST |
Gene summary for DST |
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Gene information | Species | Human | Gene symbol | DST | Gene ID | 667 |
Gene name | dystonin | |
Gene Alias | BP240 | |
Cytomap | 6p12.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B4DSS9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
667 | DST | GSM4909281 | Human | Breast | IDC | 2.92e-03 | -3.62e-01 | 0.21 |
667 | DST | GSM4909282 | Human | Breast | IDC | 3.84e-17 | -5.25e-01 | -0.0288 |
667 | DST | GSM4909286 | Human | Breast | IDC | 1.03e-06 | -3.84e-01 | 0.1081 |
667 | DST | GSM4909287 | Human | Breast | IDC | 1.34e-08 | -4.01e-01 | 0.2057 |
667 | DST | GSM4909290 | Human | Breast | IDC | 1.17e-08 | -4.62e-01 | 0.2096 |
667 | DST | GSM4909293 | Human | Breast | IDC | 3.47e-11 | -4.92e-01 | 0.1581 |
667 | DST | GSM4909294 | Human | Breast | IDC | 2.89e-05 | -4.28e-01 | 0.2022 |
667 | DST | GSM4909296 | Human | Breast | IDC | 1.18e-17 | -5.60e-01 | 0.1524 |
667 | DST | GSM4909297 | Human | Breast | IDC | 2.00e-12 | -5.14e-01 | 0.1517 |
667 | DST | GSM4909298 | Human | Breast | IDC | 1.93e-02 | -3.56e-01 | 0.1551 |
667 | DST | GSM4909301 | Human | Breast | IDC | 2.86e-05 | -4.36e-01 | 0.1577 |
667 | DST | GSM4909302 | Human | Breast | IDC | 1.83e-15 | -4.79e-01 | 0.1545 |
667 | DST | GSM4909303 | Human | Breast | IDC | 7.43e-03 | -4.71e-01 | 0.0438 |
667 | DST | GSM4909304 | Human | Breast | IDC | 2.01e-22 | -6.00e-01 | 0.1636 |
667 | DST | GSM4909305 | Human | Breast | IDC | 8.32e-04 | -3.64e-01 | 0.0436 |
667 | DST | GSM4909306 | Human | Breast | IDC | 5.79e-17 | -5.62e-01 | 0.1564 |
667 | DST | GSM4909307 | Human | Breast | IDC | 3.63e-03 | -3.62e-01 | 0.1569 |
667 | DST | GSM4909308 | Human | Breast | IDC | 2.15e-08 | -4.20e-01 | 0.158 |
667 | DST | GSM4909309 | Human | Breast | IDC | 3.83e-06 | -3.24e-01 | 0.0483 |
667 | DST | GSM4909311 | Human | Breast | IDC | 5.66e-29 | -5.93e-01 | 0.1534 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00420609 | Breast | Precancer | wound healing | 48/1080 | 422/18723 | 5.48e-06 | 1.63e-04 | 48 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:0045104 | Breast | Precancer | intermediate filament cytoskeleton organization | 11/1080 | 51/18723 | 1.26e-04 | 2.22e-03 | 11 |
GO:0045103 | Breast | Precancer | intermediate filament-based process | 11/1080 | 52/18723 | 1.52e-04 | 2.60e-03 | 11 |
GO:00070159 | Breast | Precancer | actin filament organization | 44/1080 | 442/18723 | 3.02e-04 | 4.35e-03 | 44 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:00329569 | Breast | Precancer | regulation of actin cytoskeleton organization | 36/1080 | 358/18723 | 8.56e-04 | 9.88e-03 | 36 |
GO:01100539 | Breast | Precancer | regulation of actin filament organization | 29/1080 | 278/18723 | 1.50e-03 | 1.55e-02 | 29 |
GO:00071638 | Breast | Precancer | establishment or maintenance of cell polarity | 23/1080 | 218/18723 | 3.82e-03 | 3.06e-02 | 23 |
GO:01501158 | Breast | Precancer | cell-substrate junction organization | 13/1080 | 101/18723 | 5.30e-03 | 3.94e-02 | 13 |
GO:190290514 | Breast | IDC | positive regulation of supramolecular fiber organization | 37/1434 | 209/18723 | 1.33e-06 | 5.75e-05 | 37 |
GO:003297014 | Breast | IDC | regulation of actin filament-based process | 56/1434 | 397/18723 | 6.37e-06 | 1.99e-04 | 56 |
GO:190290314 | Breast | IDC | regulation of supramolecular fiber organization | 54/1434 | 383/18723 | 9.40e-06 | 2.66e-04 | 54 |
GO:005149513 | Breast | IDC | positive regulation of cytoskeleton organization | 35/1434 | 226/18723 | 5.04e-05 | 1.09e-03 | 35 |
GO:004206014 | Breast | IDC | wound healing | 55/1434 | 422/18723 | 7.27e-05 | 1.45e-03 | 55 |
GO:003295614 | Breast | IDC | regulation of actin cytoskeleton organization | 48/1434 | 358/18723 | 1.03e-04 | 1.96e-03 | 48 |
GO:000701514 | Breast | IDC | actin filament organization | 55/1434 | 442/18723 | 2.45e-04 | 3.84e-03 | 55 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DST | SNV | Missense_Mutation | c.12548N>T | p.Cys4183Phe | p.C4183F | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-49-6767-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DST | SNV | Missense_Mutation | novel | c.14471G>T | p.Ser4824Ile | p.S4824I | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-49-AARO-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
DST | SNV | Missense_Mutation | c.11850G>C | p.Lys3950Asn | p.K3950N | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-49-AARO-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
DST | SNV | Missense_Mutation | c.12409N>T | p.Asp4137Tyr | p.D4137Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-5933-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | ||
DST | SNV | Missense_Mutation | c.9404N>C | p.Arg3135Pro | p.R3135P | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-50-5946-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
DST | SNV | Missense_Mutation | c.6094N>A | p.Asp2032Asn | p.D2032N | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-50-7109-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
DST | SNV | Missense_Mutation | novel | c.16046N>T | p.Arg5349Ile | p.R5349I | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-1592-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DST | SNV | Missense_Mutation | novel | c.12388G>T | p.Asp4130Tyr | p.D4130Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD | |
DST | SNV | Missense_Mutation | novel | c.15019A>G | p.Thr5007Ala | p.T5007A | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-55-7281-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
DST | SNV | Missense_Mutation | c.5712N>T | p.Glu1904Asp | p.E1904D | protein_coding | tolerated(0.27) | benign(0.127) | TCGA-55-7283-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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