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Gene: MUC4 |
Gene summary for MUC4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MUC4 | Gene ID | 4585 |
Gene name | mucin 4, cell surface associated | |
Gene Alias | ASGP | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | A0A0G2JS65 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4585 | MUC4 | CA_HPV_1 | Human | Cervix | CC | 2.47e-13 | -4.35e-01 | 0.0264 |
4585 | MUC4 | CA_HPV_2 | Human | Cervix | CC | 1.01e-04 | 3.87e-01 | 0.0391 |
4585 | MUC4 | CA_HPV_3 | Human | Cervix | CC | 2.67e-04 | -3.53e-01 | 0.0414 |
4585 | MUC4 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 2.89e-06 | -3.66e-01 | 0.0116 |
4585 | MUC4 | N_HPV_1 | Human | Cervix | N_HPV | 7.88e-11 | -4.46e-01 | 0.0079 |
4585 | MUC4 | N_HPV_2 | Human | Cervix | N_HPV | 2.68e-06 | -3.35e-01 | -0.0131 |
4585 | MUC4 | CCI_1 | Human | Cervix | CC | 8.65e-11 | 2.05e+00 | 0.528 |
4585 | MUC4 | CCI_3 | Human | Cervix | CC | 6.04e-15 | 1.74e+00 | 0.516 |
4585 | MUC4 | CCII_1 | Human | Cervix | CC | 1.41e-07 | 6.28e-01 | 0.3249 |
4585 | MUC4 | Tumor | Human | Cervix | CC | 2.34e-19 | 5.37e-01 | 0.1241 |
4585 | MUC4 | sample3 | Human | Cervix | CC | 5.32e-52 | 8.62e-01 | 0.1387 |
4585 | MUC4 | H2 | Human | Cervix | HSIL_HPV | 5.42e-13 | 5.57e-01 | 0.0632 |
4585 | MUC4 | T1 | Human | Cervix | CC | 5.89e-17 | 6.36e-01 | 0.0918 |
4585 | MUC4 | T3 | Human | Cervix | CC | 8.21e-52 | 8.26e-01 | 0.1389 |
4585 | MUC4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.66e-16 | -6.22e-01 | 0.0155 |
4585 | MUC4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.97e-10 | 5.97e-01 | -0.1954 |
4585 | MUC4 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.02e-03 | 6.25e-01 | -0.2602 |
4585 | MUC4 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.69e-05 | 5.39e-01 | -0.1526 |
4585 | MUC4 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.30e-03 | 7.83e-01 | -0.1464 |
4585 | MUC4 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.76e-08 | 7.11e-01 | -0.1001 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00018949 | Cervix | CC | tissue homeostasis | 57/2311 | 268/18723 | 2.43e-05 | 4.21e-04 | 57 |
GO:00602498 | Cervix | CC | anatomical structure homeostasis | 63/2311 | 314/18723 | 6.03e-05 | 8.68e-04 | 63 |
GO:000189414 | Cervix | HSIL_HPV | tissue homeostasis | 25/737 | 268/18723 | 6.17e-05 | 1.46e-03 | 25 |
GO:003158914 | Cervix | HSIL_HPV | cell-substrate adhesion | 30/737 | 363/18723 | 1.12e-04 | 2.34e-03 | 30 |
GO:006024913 | Cervix | HSIL_HPV | anatomical structure homeostasis | 25/737 | 314/18723 | 7.04e-04 | 9.40e-03 | 25 |
GO:000189424 | Cervix | N_HPV | tissue homeostasis | 23/534 | 268/18723 | 2.86e-06 | 1.24e-04 | 23 |
GO:006024923 | Cervix | N_HPV | anatomical structure homeostasis | 24/534 | 314/18723 | 1.27e-05 | 4.17e-04 | 24 |
GO:003158924 | Cervix | N_HPV | cell-substrate adhesion | 23/534 | 363/18723 | 3.24e-04 | 4.84e-03 | 23 |
GO:000716013 | Cervix | N_HPV | cell-matrix adhesion | 14/534 | 233/18723 | 7.21e-03 | 4.74e-02 | 14 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0007160 | Colorectum | AD | cell-matrix adhesion | 75/3918 | 233/18723 | 3.56e-05 | 6.45e-04 | 75 |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:0030277 | Colorectum | AD | maintenance of gastrointestinal epithelium | 10/3918 | 22/18723 | 8.52e-03 | 4.97e-02 | 10 |
GO:00315891 | Colorectum | SER | cell-substrate adhesion | 86/2897 | 363/18723 | 2.36e-05 | 6.64e-04 | 86 |
GO:00018941 | Colorectum | SER | tissue homeostasis | 66/2897 | 268/18723 | 5.87e-05 | 1.37e-03 | 66 |
GO:00602491 | Colorectum | SER | anatomical structure homeostasis | 74/2897 | 314/18723 | 1.01e-04 | 2.13e-03 | 74 |
GO:0022600 | Colorectum | SER | digestive system process | 29/2897 | 104/18723 | 8.57e-04 | 1.05e-02 | 29 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC4 | SNV | Missense_Mutation | novel | c.653N>G | p.Thr218Ser | p.T218S | protein_coding | tolerated_low_confidence(0.44) | benign(0.301) | TCGA-43-7656-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MUC4 | SNV | Missense_Mutation | novel | c.2746N>G | p.Ser916Gly | p.S916G | protein_coding | tolerated_low_confidence(0.19) | benign(0.159) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MUC4 | SNV | Missense_Mutation | rs376185784 | c.15721N>T | p.Arg5241Trp | p.R5241W | protein_coding | tolerated_low_confidence(0.11) | benign(0) | TCGA-56-8305-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MUC4 | SNV | Missense_Mutation | novel | c.13355N>T | p.Thr4452Met | p.T4452M | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.914) | TCGA-56-8626-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MUC4 | SNV | Missense_Mutation | c.1014N>G | p.Ile338Met | p.I338M | protein_coding | deleterious_low_confidence(0.03) | benign(0.318) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
MUC4 | SNV | Missense_Mutation | novel | c.743N>T | p.Ser248Leu | p.S248L | protein_coding | deleterious_low_confidence(0.04) | benign(0.316) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MUC4 | SNV | Missense_Mutation | novel | c.12973G>T | p.Ala4325Ser | p.A4325S | protein_coding | tolerated_low_confidence(0.08) | benign(0.007) | TCGA-58-8388-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MUC4 | SNV | Missense_Mutation | novel | c.15157N>A | p.Ser5053Thr | p.S5053T | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.991) | TCGA-58-A46M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MUC4 | SNV | Missense_Mutation | novel | c.2074G>T | p.Ala692Ser | p.A692S | protein_coding | deleterious_low_confidence(0.04) | benign(0.374) | TCGA-63-A5MB-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
MUC4 | SNV | Missense_Mutation | novel | c.14816N>T | p.Ser4939Ile | p.S4939I | protein_coding | tolerated_low_confidence(0.39) | benign(0.015) | TCGA-66-2766-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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