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Gene: FAT1 |
Gene summary for FAT1 |
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Gene information | Species | Human | Gene symbol | FAT1 | Gene ID | 2195 |
Gene name | FAT atypical cadherin 1 | |
Gene Alias | CDHF7 | |
Cytomap | 4q35.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q14517 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2195 | FAT1 | CA_HPV_1 | Human | Cervix | CC | 5.98e-15 | -3.11e-01 | 0.0264 |
2195 | FAT1 | CCI_3 | Human | Cervix | CC | 1.19e-05 | 8.23e-01 | 0.516 |
2195 | FAT1 | T1 | Human | Cervix | CC | 8.35e-04 | 3.31e-01 | 0.0918 |
2195 | FAT1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.57e-15 | -5.42e-01 | 0.0155 |
2195 | FAT1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.35e-03 | -5.50e-01 | -0.1207 |
2195 | FAT1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.36e-03 | 5.78e-01 | 0.3859 |
2195 | FAT1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.39e-03 | -3.73e-01 | 0.3005 |
2195 | FAT1 | F007 | Human | Colorectum | FAP | 1.81e-03 | 1.49e-01 | 0.1176 |
2195 | FAT1 | A002-C-010 | Human | Colorectum | FAP | 6.29e-03 | 3.65e-02 | 0.242 |
2195 | FAT1 | A001-C-207 | Human | Colorectum | FAP | 1.14e-04 | 4.28e-02 | 0.1278 |
2195 | FAT1 | A015-C-203 | Human | Colorectum | FAP | 1.38e-32 | -4.57e-02 | -0.1294 |
2195 | FAT1 | A015-C-204 | Human | Colorectum | FAP | 1.72e-06 | -1.83e-01 | -0.0228 |
2195 | FAT1 | A014-C-040 | Human | Colorectum | FAP | 1.94e-05 | -7.64e-02 | -0.1184 |
2195 | FAT1 | A002-C-201 | Human | Colorectum | FAP | 5.22e-16 | -3.65e-02 | 0.0324 |
2195 | FAT1 | A002-C-203 | Human | Colorectum | FAP | 1.89e-02 | -2.00e-02 | 0.2786 |
2195 | FAT1 | A001-C-119 | Human | Colorectum | FAP | 3.69e-07 | -2.78e-02 | -0.1557 |
2195 | FAT1 | A001-C-108 | Human | Colorectum | FAP | 5.20e-20 | 2.08e-01 | -0.0272 |
2195 | FAT1 | A002-C-021 | Human | Colorectum | FAP | 3.10e-02 | 3.32e-01 | 0.1171 |
2195 | FAT1 | A002-C-205 | Human | Colorectum | FAP | 4.87e-33 | 2.56e-01 | -0.1236 |
2195 | FAT1 | A001-C-104 | Human | Colorectum | FAP | 2.64e-07 | 2.02e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:00300108 | Cervix | CC | establishment of cell polarity | 42/2311 | 143/18723 | 4.30e-08 | 2.62e-06 | 42 |
GO:000206410 | Cervix | CC | epithelial cell development | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:00901627 | Cervix | CC | establishment of epithelial cell polarity | 11/2311 | 31/18723 | 7.87e-04 | 6.96e-03 | 11 |
GO:00017384 | Cervix | CC | morphogenesis of a polarized epithelium | 22/2311 | 94/18723 | 2.09e-03 | 1.52e-02 | 22 |
GO:0150063 | Cervix | CC | visual system development | 63/2311 | 375/18723 | 6.58e-03 | 3.65e-02 | 63 |
GO:0001654 | Cervix | CC | eye development | 62/2311 | 371/18723 | 7.83e-03 | 4.13e-02 | 62 |
GO:0048880 | Cervix | CC | sensory system development | 63/2311 | 381/18723 | 9.29e-03 | 4.66e-02 | 63 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:0030010 | Colorectum | AD | establishment of cell polarity | 50/3918 | 143/18723 | 6.90e-05 | 1.11e-03 | 50 |
GO:0045197 | Colorectum | AD | establishment or maintenance of epithelial cell apical/basal polarity | 20/3918 | 44/18723 | 2.26e-04 | 2.94e-03 | 20 |
GO:0035088 | Colorectum | AD | establishment or maintenance of apical/basal cell polarity | 21/3918 | 49/18723 | 4.31e-04 | 4.82e-03 | 21 |
GO:0061245 | Colorectum | AD | establishment or maintenance of bipolar cell polarity | 21/3918 | 49/18723 | 4.31e-04 | 4.82e-03 | 21 |
GO:0001738 | Colorectum | AD | morphogenesis of a polarized epithelium | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:0030859 | Colorectum | AD | polarized epithelial cell differentiation | 11/3918 | 24/18723 | 5.43e-03 | 3.55e-02 | 11 |
GO:0090162 | Colorectum | AD | establishment of epithelial cell polarity | 13/3918 | 31/18723 | 6.53e-03 | 4.06e-02 | 13 |
GO:00070152 | Colorectum | MSS | actin filament organization | 146/3467 | 442/18723 | 1.16e-13 | 2.67e-11 | 146 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAT1 | SNV | Missense_Mutation | novel | c.7252N>T | p.Asp2418Tyr | p.D2418Y | Q14517 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-85-A4JB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | CR |
FAT1 | SNV | Missense_Mutation | novel | c.7693N>G | p.Ser2565Ala | p.S2565A | Q14517 | protein_coding | tolerated(1) | benign(0.001) | TCGA-94-A5I6-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
FAT1 | SNV | Missense_Mutation | novel | c.12019N>T | p.Pro4007Ser | p.P4007S | Q14517 | protein_coding | tolerated(0.15) | benign(0.027) | TCGA-96-8170-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAT1 | SNV | Missense_Mutation | novel | c.6693N>A | p.Phe2231Leu | p.F2231L | Q14517 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-J1-A4AH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
FAT1 | SNV | Missense_Mutation | novel | c.12366A>T | p.Glu4122Asp | p.E4122D | Q14517 | protein_coding | tolerated(0.39) | benign(0.022) | TCGA-L3-A524-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAT1 | SNV | Missense_Mutation | novel | c.13644C>A | p.Asp4548Glu | p.D4548E | Q14517 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-NC-A5HE-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
FAT1 | SNV | Missense_Mutation | novel | c.9721N>C | p.Glu3241Gln | p.E3241Q | Q14517 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-NC-A5HM-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAT1 | SNV | Missense_Mutation | novel | c.12360G>T | p.Arg4120Ser | p.R4120S | Q14517 | protein_coding | tolerated(0.73) | benign(0.245) | TCGA-O2-A52N-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAT1 | deletion | Frame_Shift_Del | novel | c.12598delG | p.Val4200PhefsTer6 | p.V4200Ffs*6 | Q14517 | protein_coding | TCGA-44-2668-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
FAT1 | insertion | Frame_Shift_Ins | novel | c.3114_3115insT | p.Glu1039Ter | p.E1039* | Q14517 | protein_coding | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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